Abstract:
:Pediatric bipolar disorder (PBD) is a severely debilitating illness, which is characterized by episodes of mania and depression separated by periods of remission. Little is known about the abnormalities in PBD in resting state, especially comparing manic with euthymic state. Resting state brain activity measured by fMRI might help to explore neurobiological biomarkers of the disorder. Regional homogeneity (ReHo) was examined with resting-state fMRI on 22 manic PBD patients, 21 euthymic PBD patients and 19 healthy controls. Compared with control group, manic group presented reduced cortical ReHo signal in the superior temporal gyrus(STG), the superior parietal lobe (SPL), precentral gyrus and altered subcortical ReHo signal in the insula and cerebelum crus I. Compared with control group, euthymic group only presented reduced cortical ReHo signal in the STG and SPL. Compared with euthymic group, we found reduced ReHo signal in insula, the STG and increased ReHo signal in cerebelum crus I in the manic group. The neural regions we found to have altered ReHo signal in the PBD manic and euthymic group are parts of the cortical-limbic systems, which are important for affective and cognitive processing. Importantly, our findings suggested that there was a difference between manic and euthymic PBD in the insula, cerebelum crus I and the STG.
journal_name
Brain Imaging Behavjournal_title
Brain imaging and behaviorauthors
Xiao Q,Cui D,Jiao Q,Zhong Y,Cao W,Lu G,Su Ldoi
10.1007/s11682-019-00117-4subject
Has Abstractpub_date
2019-12-01 00:00:00pages
1789-1798issue
6eissn
1931-7557issn
1931-7565pii
10.1007/s11682-019-00117-4journal_volume
13pub_type
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pub_type: 杂志文章,评审
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