Reduced gray matter volume in cognitively preserved COMT 158Val/Val Parkinson's disease patients and its association with cognitive decline.

Abstract:

:The COMT Val158Met polymorphism has recently been identified as a predictor for cognitive decline in Parkinson's disease (PD). However, it remains unknown whether an early brain structural compromise could be involved in this clinical association. Here, in a cohort of 120 cognitively preserved de novo PD patients from the Parkinson's Progression Markers Initiative (PPMI) database, we found a widespread reduction in cerebral gray matter volume (GMV) in patients harboring the Val/Val genotype. The atrophic pattern included fronto-subcortical and parieto-temporal territories. Importantly, the GMV at some of the identified regions was associated with cognitive decline in a 4-year follow-up period. These findings suggest that GMV compromise in the early stages of PD may be a predisposing factor for cognitive decline of COMT Val/Val homozygotes.

journal_name

Brain Imaging Behav

authors

Sampedro F,Marín-Lahoz J,Martínez-Horta S,Pagonabarraga J,Kulisevsky J

doi

10.1007/s11682-018-0022-y

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

321-328

issue

2

eissn

1931-7557

issn

1931-7565

pii

10.1007/s11682-018-0022-y

journal_volume

14

pub_type

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