Abstract:
:The COMT Val158Met polymorphism has recently been identified as a predictor for cognitive decline in Parkinson's disease (PD). However, it remains unknown whether an early brain structural compromise could be involved in this clinical association. Here, in a cohort of 120 cognitively preserved de novo PD patients from the Parkinson's Progression Markers Initiative (PPMI) database, we found a widespread reduction in cerebral gray matter volume (GMV) in patients harboring the Val/Val genotype. The atrophic pattern included fronto-subcortical and parieto-temporal territories. Importantly, the GMV at some of the identified regions was associated with cognitive decline in a 4-year follow-up period. These findings suggest that GMV compromise in the early stages of PD may be a predisposing factor for cognitive decline of COMT Val/Val homozygotes.
journal_name
Brain Imaging Behavjournal_title
Brain imaging and behaviorauthors
Sampedro F,Marín-Lahoz J,Martínez-Horta S,Pagonabarraga J,Kulisevsky Jdoi
10.1007/s11682-018-0022-ysubject
Has Abstractpub_date
2020-04-01 00:00:00pages
321-328issue
2eissn
1931-7557issn
1931-7565pii
10.1007/s11682-018-0022-yjournal_volume
14pub_type
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