Abstract:
:Clinical neuropsychology lacks tests of basic visuoperceptual and spatial skills that have well-controlled administration and sophisticated measurement methods. Items from the Visual Assessment Battery (VAB), a simultaneous match-to-sample task, assessed visual discrimination in 40 healthy adults aged 51-91 during fMRI. The tasks were designed to isolate discrimination of either location, shape, or velocity, and they each had three levels of difficulty. The Location task uniquely activated the dorsal visual processing stream, the Shape task the ventral stream, and the Velocity task an area encompassing V5. Greater age was associated with greater neural recruitment, particularly in frontal areas. Behaviorally, greater age was associated with prolonged response times, but not reduced accuracy. Increased difficulty was associated with slower responses and reduced accuracy, regardless of age. Results validated the specialization of brain regions for spatial, perceptual, and movement discriminations and the use of the VAB to assess functioning localized to these regions. Visual discrimination ability does not change dramatically with age, but like many cognitive processes, performance slows. Anterior neural recruitment during visual discrimination increases with age.
journal_name
Brain Imaging Behavjournal_title
Brain imaging and behaviorauthors
Seider TR,Porges EC,Woods AJ,Cohen RAdoi
10.1007/s11682-020-00301-xsubject
Has Abstractpub_date
2020-07-25 00:00:00eissn
1931-7557issn
1931-7565pii
10.1007/s11682-020-00301-xpub_type
杂志文章abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive muscular weakness and atrophy. Several morphometric studies have been conducted to investigate the gray matter volume or thickness changes in ALS, whereas the cortical folding pattern remains poorly understood. In the...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-015-9499-9
更新日期:2017-02-01 00:00:00
abstract::In patients with premotor Huntington's disease (pmHD), literature has reported decreases in caudate volume. However, the regional vulnerability of the caudate nucleus to pmHD remains to be clarified. We aimed to determine whether regional structural damage of the caudate nucleus was present in pmHD and was correlated ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-016-9616-4
更新日期:2017-10-01 00:00:00
abstract::Because adolescence is a period of heightened exploration of new behaviors, there is a natural increase in risk taking including initial use of alcohol and marijuana. In order to better understand potential differences in neurocognitive functioning among adolescents who use drugs, the current study aimed to identify t...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-017-9723-x
更新日期:2018-04-01 00:00:00
abstract::Gyrification of the cortical mantle is a dynamic process that increases with cortical surface area and decreases with age. Increased gyrification is associated with higher scores on cognitive tasks in adults; however, the degree to which this relationship is independent of cortical surface area remains undefined. This...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-017-9696-9
更新日期:2018-04-01 00:00:00
abstract::The current report used structural magnetic resonance imaging (MRI) to objectively measure olfactory bulb volume and olfactory sulcal depth in patients diagnosed with chronic schizophrenia and healthy controls. Additional measures were obtained to assess olfactory function. The olfactory bulb and sulcus were manually ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-011-9129-0
更新日期:2011-12-01 00:00:00
abstract::No known studies have directly examined white matter microstructural correlates of cognitive fatigue post-TBI in a Veteran sample. We therefore investigated the relationship between cognitive fatigue and white matter integrity in Veterans with history of mild to moderate TBI (mmTBI). 59 Veterans (TBI = 34, Veteran Con...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-016-9594-6
更新日期:2017-10-01 00:00:00
abstract::Assessing functional brain activation patterns in neuropsychiatric disorders such as cocaine dependence (CD) or pathological gambling (PG) under naturalistic stimuli has received rising interest in recent years. In this paper, we propose and apply a novel group-wise sparse representation framework to assess difference...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-016-9596-4
更新日期:2017-08-01 00:00:00
abstract::The cerebellum is known to influence cerebral cortical activity via cerebello-thalamo-cortical (CTC) circuits and thereby may be implicated in the pathophysiology of multiple system atrophy (MSA). As the aim of this study, we investigated the abnormalities of corticocerebellar functional connectivity (FC) in patients ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00097-5
更新日期:2019-12-01 00:00:00
abstract::The present study evaluates the integrity of uncinate fasciculus (UF) and the association between UF microstructure and verbal episodic memory (as one of the cognitive functions linked to UF) in non-demented patients with amyotrophic lateral sclerosis (ALS) using diffusion tensor imaging (DTI). We studied 21 patients ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-013-9271-y
更新日期:2014-12-01 00:00:00
abstract::Recent changes in diagnostic criteria for Alzheimer's disease (AD) state that biomarkers can enhance certainty in a diagnosis of AD. In the present study, we combined cognitive function and brain morphology, a potential imaging biomarker, to predict conversion from mild cognitive impairment to AD. We identified four b...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-012-9180-5
更新日期:2012-12-01 00:00:00
abstract::Cognitive deficits, especially in the domains of social cognition and executive function including verbal fluency, are common in amyotrophic lateral sclerosis (ALS) patients. There is yet sparse understanding of pathogenesis of the underlying, possibly adaptive, cortical patterns. To address this issue, 65 patients wi...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-017-9738-3
更新日期:2018-06-01 00:00:00
abstract::The author found a mistake in their published article. The sentence "The search region was limited within each side of the white matter." should read as "The search regions was limited within each side of the white matter at and above Z=0." ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章,已发布勘误
doi:10.1007/s11682-019-00173-w
更新日期:2020-04-01 00:00:00
abstract::Neuroimaging studies have implicated abnormal brain microstructure in episodic migraine (EM), but whether the pattern is altered during migraine chronification is not well known. Fifty-six patients with migraine without aura, including 39 EM patients and 17 chronic migraine (CM) patients, and 35 healthy controls (HCs)...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00232-2
更新日期:2021-02-01 00:00:00
abstract::The ability to suppress responses that are inappropriate, as well as the mechanisms monitoring the accuracy of actions in order to compensate for errors, is central to human behavior. Neural alterations that prevent stopping an inaccurate response, combined with a decreased ability of error monitoring, are considered ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-016-9654-y
更新日期:2017-12-01 00:00:00
abstract::Diffusion tensor imaging (DTI) has demonstrated its utility in detecting microscopic post-concussion cerebral white matter structural changes, which are not routinely evident on conventional neuroimaging modalities. In this study, we compared 10 adolescents with sports concussion (SC) to 12 orthopedically-injured (OI)...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-017-9752-5
更新日期:2018-08-01 00:00:00
abstract::The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium brings together researchers from around the world to try to identify the genetic underpinnings of brain structure and function, along with robust, generalizable effects of neurological and psychiatric disorders. The recently-formed ENIGMA Br...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-021-00450-7
更新日期:2021-01-27 00:00:00
abstract::This study further investigates the influence of temporarily disrupting the blood-brain barrier (BBB) on the level of manganese used in AIM fMRI other than the recognized function of allowing that substance to enter into the activated brain regions more effectively during the BBB opening. We injected manganese into Wi...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-011-9122-7
更新日期:2011-09-01 00:00:00
abstract::Skin-picking disorder (SPD) is a common mental disorder characterized by recurrent and excessive picking of dermatological irregularities. Different disorder models have been developed to explain this behavior, but empirical evidence is still scarce. One model (the disgust-related disease avoidance model) suggests tha...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-017-9792-x
更新日期:2018-10-01 00:00:00
abstract::The neuroimaging literature in moral cognition has rapidly developed in the last decade with more than 200 publications on the topic. Neuroimaging based models generally agree that limbic regions work with medial prefrontal and temporal regions during moral processing to integrate emotional, social, and cognitive elem...
journal_title:Brain imaging and behavior
pub_type: 杂志文章,meta分析
doi:10.1007/s11682-019-00035-5
更新日期:2020-04-01 00:00:00
abstract::Genetic variation in the kidney and brain expressed protein (KIBRA) rs17070145 gene has been linked to episodic memory and cognitive aging; yet, the neural mechanism underlying this association remains to be fully understood. Using the magnetic resonance imaging (MRI) technique, this study investigated the effect of K...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00047-1
更新日期:2020-10-01 00:00:00
abstract::Nicotine addiction is characterized as a neural circuit dysfunction, particularly with regard to the alterations in central reward pathways. The insula, a cortical region that is thought to play a central role in this reward circuitry, has been implicated in the maintenance of nicotine addiction. However, it remains l...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-020-00389-1
更新日期:2020-09-24 00:00:00
abstract::Genetic factors account for up to 80% of the liability for schizophrenia (SCZ) and bipolar disorder (BD). Genome-wide association studies have successfully identified several genes associated with increased risk for both disorders. This has allowed researchers to model the aggregate effect of genes associated with dis...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-018-9879-z
更新日期:2019-06-01 00:00:00
abstract::The clinical relevance of gray/white matter contrast ratio (GWR) in mild cognitive impairment (MCI) remains unknown. This study examined baseline GWR and 3-year follow-up diagnostic status in MCI. Alzheimer's Disease Neuroimaging Initiative MCI participants with baseline 1.5 T MRI and 3-year follow-up clinical data we...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-014-9291-2
更新日期:2015-06-01 00:00:00
abstract::Parkinson's disease (PD) is associated with abnormal synchronization in basal ganglia-thalamo-cortical loops. We tested whether early PD patients without demonstrable cognitive impairment exhibit abnormal modulation of functional connectivity at rest, while engaged in a task, or both. PD and healthy controls underwent...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-014-9317-9
更新日期:2015-09-01 00:00:00
abstract::It is a generally accepted observation that individuals act differently under stress. Recent task-based neuroimaging studies have shown that individuals under stress favor the intuitive and fast system over the deliberative and reflective system. In the present study, using a within-subjects design in thirty young adu...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-018-9898-9
更新日期:2019-06-01 00:00:00
abstract::Congenital heart disease is the most common birth defect, and patients are at risk for neurodevelopmental impairment and brain abnormalities. Yet, little is known about the link between brain volumes and cognitive function in adults with congenital heart disease. Forty-four patients and 53 controls between 18 and 32 y...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-020-00424-1
更新日期:2021-01-30 00:00:00
abstract::Previous meta-analyses found abnormal brain activations in schizophrenia patients compared with normal controls when performing working memory tasks. Although most studies focused on dysfunction of the working memory activation network in schizophrenia patients, deactivation abnormalities of the working memory in the ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00071-1
更新日期:2020-08-01 00:00:00
abstract::Copy number variants at the chromosomal locus 16p11.2 contribute to neurodevelopmental disorders such as autism spectrum disorders, epilepsy, schizophrenia, and language and articulation disorders. Here, we provide detailed findings on the disrupted structural brain connectivity in 16p11.2 deletion syndrome (patients:...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-018-9859-3
更新日期:2019-04-01 00:00:00
abstract::Three to 6 months after an acute coronary syndrome (ACS), cognitive impairment is observed in more than 30 % of the patients, mainly in executive functioning. The aim of this study was to investigate, using multimodal MRI, cerebral anatomo-functional substratum of executive dysfunction. Thirty-three patients were recr...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-015-9483-4
更新日期:2016-09-01 00:00:00
abstract::The perception of the faces of parents is different from that of other faces. Mother's face perception is associated with childbearing and parenting and has specific cognitive processing properties. Yet, the underlying mechanism remains unknown. We investigated the neural network that is involved in the perception of ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-015-9486-1
更新日期:2016-12-01 00:00:00