The dissociative subtype of posttraumatic stress disorder is associated with subcortical white matter network alterations.

Abstract:

:Posttraumatic stress disorder (PTSD) is characterized by intrusions, avoidance, and hyperarousal while patients of the dissociative subtype (PTSD-D) experience additional dissociative symptoms. A neurobiological model proposes hyper-inhibition of limbic structures mediated by prefrontal cortices to underlie dissociation in PTSD. Here, we tested whether functional alterations in fronto-limbic circuits are underpinned by white matter network abnormalities on a network level. 23 women with PTSD-D and 19 women with classic PTSD participated. We employed deterministic diffusion tractography and graph theoretical analyses. Mean fractional anisotropy (FA) was chosen as a network weight and group differences assessed using network-based statistics. No significant white matter network alterations comprising both frontal and limbic structures in PTSD-D relative to classic PTSD were found. A subsequent whole brain exploratory analysis revealed relative FA alterations in PTSD-D in two subcortical networks, comprising connections between the left amygdala, hippocampus, and thalamus as well as links between the left ventral diencephalon, putamen, and pallidum, respectively. Dissociative symptom severity in the PTSD-D group correlated with FA values within both networks. Our findings suggest fronto-limbic inhibition in PTSD-D may present a dynamic neural process, which is not hard-wired via white matter tracts. Our exploratory results point towards altered fiber tract communication in a limbic-thalamic circuit, which may underlie (a) an initial strong emotional reaction to trauma reminders before conscious regulatory processes are enabled and (b) deficits in early sensory processing. In addition, aberrant structural connectivity in low-level motor regions may present neural correlates for dissociation as a passive threat-response.

journal_name

Brain Imaging Behav

authors

Sierk A,Manthey A,Brakemeier EL,Walter H,Daniels JK

doi

10.1007/s11682-020-00274-x

subject

Has Abstract

pub_date

2020-04-27 00:00:00

eissn

1931-7557

issn

1931-7565

pii

10.1007/s11682-020-00274-x

pub_type

杂志文章
  • Altered white matter structural networks in drug-naïve patients with obsessive-compulsive disorder.

    abstract::White matter (WM) alteration is considered to be a vital neurological mechanism of obsessive-compulsive disorder (OCD). However, little is known regarding the changes in topological organization of WM structural network in OCD. We acquired diffusion tensor imaging (DTI) datasets from 28 drug-naïve OCD patients and 28 ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-020-00278-7

    authors: Zhou C,Ping L,Chen W,He M,Xu J,Shen Z,Lu Y,Shang B,Xu X,Cheng Y

    更新日期:2020-04-20 00:00:00

  • Imaging genetics in attention-deficit/hyperactivity disorder and related neurodevelopmental domains: state of the art.

    abstract::Joint analysis of genetic and neuroimaging data, known as Imaging Genetics (IG), offers an opportunity to deepen our knowledge of the biological mechanisms of neurodevelopmental domains. There has been exponential growth in the literature on IG studies, which challenges the standardization of analysis methods in this ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章,评审

    doi:10.1007/s11682-016-9663-x

    authors: Vilor-Tejedor N,Cáceres A,Pujol J,Sunyer J,González JR

    更新日期:2017-12-01 00:00:00

  • Recruitment and stabilization of brain activation within a working memory task; an FMRI study.

    abstract::Seventeen subjects underwent functional magnetic resonance imaging (fMRI) performing a 2-Back verbal working memory (VWM) task alternating with a control task to characterize the temporal dynamics of the specific brain regions involved in VWM. Serial sampling of 2-Back sub-blocks revealed many small areas of activatio...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-009-9081-4

    authors: Paskavitz JF,Sweet LH,Wellen J,Helmer KG,Rao SM,Cohen RA

    更新日期:2010-03-01 00:00:00

  • Effects of methylphenidate during emotional processing in amphetamine users: preliminary findings.

    abstract::D-amphetamine (dAMPH) and methylphenidate (MPH) are stimulants used in the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Preclinical studies have shown that in healthy animals, dAMPH induces dopamine (DA) dysfunction, as evidenced for instance by loss of DA levels and its transporters. It has also been...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-014-9350-8

    authors: Bottelier MA,Schouw ML,de Ruiter MB,Ruhe HG,Lindauer RJ,Reneman L

    更新日期:2015-12-01 00:00:00

  • Altered regional homogeneity in pediatric bipolar disorder during manic and euthymic state: a resting-state fMRI study.

    abstract::Pediatric bipolar disorder (PBD) is a severely debilitating illness, which is characterized by episodes of mania and depression separated by periods of remission. Little is known about the abnormalities in PBD in resting state, especially comparing manic with euthymic state. Resting state brain activity measured by fM...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00117-4

    authors: Xiao Q,Cui D,Jiao Q,Zhong Y,Cao W,Lu G,Su L

    更新日期:2019-12-01 00:00:00

  • Spatial distribution bias in subject-specific abnormalities analyses.

    abstract::The neuroimaging community has seen a renewed interest in algorithms that provide a location-independent summary of subject-specific abnormalities (SSA) to assess individual lesion load. More recently, these methods have been extended to assess whether multiple individuals within the same cohort exhibit extrema in the...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9836-x

    authors: Dodd AB,Ling JM,Bedrick EJ,Meier TB,Mayer AR

    更新日期:2018-12-01 00:00:00

  • Only-child and non-only-child exhibit differences in creativity and agreeableness: evidence from behavioral and anatomical structural studies.

    abstract::Different family composition and size inevitably make only-children different from non-only-children. Previous studies have focused on the differences in behaviors, such as cognitive function and personality traits, between the only-child and the non-only-child. However, there are few studies that have focused on the ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-016-9530-9

    authors: Yang J,Hou X,Wei D,Wang K,Li Y,Qiu J

    更新日期:2017-04-01 00:00:00

  • Music supported therapy promotes motor plasticity in individuals with chronic stroke.

    abstract::Novel rehabilitation interventions have improved motor recovery by induction of neural plasticity in individuals with stroke. Of these, Music-supported therapy (MST) is based on music training designed to restore motor deficits. Music training requires multimodal processing, involving the integration and co-operation ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-015-9498-x

    authors: Ripollés P,Rojo N,Grau-Sánchez J,Amengual JL,Càmara E,Marco-Pallarés J,Juncadella M,Vaquero L,Rubio F,Duarte E,Garrido C,Altenmüller E,Münte TF,Rodríguez-Fornells A

    更新日期:2016-12-01 00:00:00

  • Reduced gray matter volume in cognitively preserved COMT 158Val/Val Parkinson's disease patients and its association with cognitive decline.

    abstract::The COMT Val158Met polymorphism has recently been identified as a predictor for cognitive decline in Parkinson's disease (PD). However, it remains unknown whether an early brain structural compromise could be involved in this clinical association. Here, in a cohort of 120 cognitively preserved de novo PD patients from...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-0022-y

    authors: Sampedro F,Marín-Lahoz J,Martínez-Horta S,Pagonabarraga J,Kulisevsky J

    更新日期:2020-04-01 00:00:00

  • Altered structural brain connectivity involving the dorsal and ventral language pathways in 16p11.2 deletion syndrome.

    abstract::Copy number variants at the chromosomal locus 16p11.2 contribute to neurodevelopmental disorders such as autism spectrum disorders, epilepsy, schizophrenia, and language and articulation disorders. Here, we provide detailed findings on the disrupted structural brain connectivity in 16p11.2 deletion syndrome (patients:...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9859-3

    authors: Ahtam B,Link N,Hoff E,Ellen Grant P,Im K

    更新日期:2019-04-01 00:00:00

  • Recognition of faces and names: multimodal physiological correlates of memory and executive function.

    abstract::We sought to characterize electrophysiological, eye-tracking and behavioral correlates of face-name recognition memory in healthy younger adults using high-density electroencephalography (EEG), infrared eye-tracking (ET), and neuropsychological measures. Twenty-one participants first studied 40 face-name (FN) pairs; 2...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-015-9420-6

    authors: Mitchell MB,Shirk SD,McLaren DG,Dodd JS,Ezzati A,Ally BA,Atri A

    更新日期:2016-06-01 00:00:00

  • Increased brain connectivity and activation after cognitive rehabilitation in Parkinson's disease: a randomized controlled trial.

    abstract::Cognitive rehabilitation programs have demonstrated efficacy in improving cognitive functions in Parkinson's disease (PD), but little is known about cerebral changes associated with an integrative cognitive rehabilitation in PD. To assess structural and functional cerebral changes in PD patients, after attending a thr...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s11682-016-9639-x

    authors: Díez-Cirarda M,Ojeda N,Peña J,Cabrera-Zubizarreta A,Lucas-Jiménez O,Gómez-Esteban JC,Gómez-Beldarrain MÁ,Ibarretxe-Bilbao N

    更新日期:2017-12-01 00:00:00

  • Motor and extra-motor gray matter integrity may underlie neurophysiologic parameters of motor function in amyotrophic lateral sclerosis: a combined voxel-based morphometry and transcranial stimulation study.

    abstract::The association between gray matter (GM) density and neurophysiologic changes is still unclear in amyotrophic lateral sclerosis (ALS). We evaluated the relationship between GM density and motor system integrity combining voxel-based morphometry (VBM) and transcranial magnetic stimulation (TMS) in ALS. We included 17 A...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9841-0

    authors: Christidi F,Karavasilis E,Velonakis G,Rentzos M,Zambelis T,Zouvelou V,Xirou S,Ferentinos P,Efstathopoulos E,Kelekis N,Evdokimidis I,Karandreas N

    更新日期:2018-12-01 00:00:00

  • Gray & white matter tissue contrast differentiates Mild Cognitive Impairment converters from non-converters.

    abstract::The clinical relevance of gray/white matter contrast ratio (GWR) in mild cognitive impairment (MCI) remains unknown. This study examined baseline GWR and 3-year follow-up diagnostic status in MCI. Alzheimer's Disease Neuroimaging Initiative MCI participants with baseline 1.5 T MRI and 3-year follow-up clinical data we...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-014-9291-2

    authors: Jefferson AL,Gifford KA,Damon S,Chapman GW 4th,Liu D,Sparling J,Dobromyslin V,Salat D,Alzheimer’s Disease Neuroimaging Initiative.

    更新日期:2015-06-01 00:00:00

  • Global white matter microstructural abnormalities associated with addiction liability score in drug naïve youth.

    abstract::Abnormalities in brain white matter (WM) structure have been reported in youths having a family history of substance use disorders (SUDs). It was hypothesized that these abnormalities constitute features of the liability for SUDs transmitted across generations. The association between severity of intergenerational ris...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-017-9679-x

    authors: Hulvershorn L,Hummer T,Wu YC,Tarter R,Rea P,Anand A,Andrew Chambers R,Finn P

    更新日期:2018-02-01 00:00:00

  • Mapping anhedonia-specific dysfunction in a transdiagnostic approach: an ALE meta-analysis.

    abstract::Anhedonia is a prominent symptom in neuropsychiatric disorders, most markedly in major depressive disorder (MDD) and schizophrenia (SZ). Emerging evidence indicates an overlap in the neural substrates of anhedonia between MDD and SZ, which supported a transdiagnostic approach. Therefore, we used activation likelihood ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s11682-015-9457-6

    authors: Zhang B,Lin P,Shi H,Öngür D,Auerbach RP,Wang X,Yao S,Wang X

    更新日期:2016-09-01 00:00:00

  • The ENIGMA Brain Injury working group: approach, challenges, and potential benefits.

    abstract::The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium brings together researchers from around the world to try to identify the genetic underpinnings of brain structure and function, along with robust, generalizable effects of neurological and psychiatric disorders. The recently-formed ENIGMA Br...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-021-00450-7

    authors: Wilde EA,Dennis EL,Tate DF

    更新日期:2021-01-27 00:00:00

  • Failing compensatory mechanisms during working memory in older apolipoprotein E-epsilon4 healthy adults.

    abstract::How and when the known genetic risk allele, apolipoprotein E-epsilon4 (APOEepsilon4), confers risk to Alzheimer's disease has yet to be determined. We studied older adults and found that APOEepsilon4 carriers had greater neural activation in the medial frontal and parahippocampal gyrus during a memory task (cluster-co...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-010-9097-9

    authors: Filbey FM,Chen G,Sunderland T,Cohen RM

    更新日期:2010-06-01 00:00:00

  • Cortical signatures of cognition and their relationship to Alzheimer's disease.

    abstract::Recent changes in diagnostic criteria for Alzheimer's disease (AD) state that biomarkers can enhance certainty in a diagnosis of AD. In the present study, we combined cognitive function and brain morphology, a potential imaging biomarker, to predict conversion from mild cognitive impairment to AD. We identified four b...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-012-9180-5

    authors: Gross AL,Manly JJ,Pa J,Johnson JK,Park LQ,Mitchell MB,Melrose RJ,Inouye SK,McLaren DG,Alzheimer’s Disease Neuroimaging Initiative.

    更新日期:2012-12-01 00:00:00

  • Correction to: Age associated decline in the arcuate fasciculus and IQ.

    abstract::The author found a mistake in their published article. The sentence "The search region was limited within each side of the white matter." should read as "The search regions was limited within each side of the white matter at and above Z=0." ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s11682-019-00173-w

    authors: Ikuta T,Gollnick HM,Rutledge AN

    更新日期:2020-04-01 00:00:00

  • Participation in cognitively-stimulating activities is associated with brain structure and cognitive function in preclinical Alzheimer's disease.

    abstract::This study tested the hypothesis that frequent participation in cognitively-stimulating activities, specifically those related to playing games and puzzles, is beneficial to brain health and cognition among middle-aged adults at increased risk for Alzheimer's disease (AD). Three hundred twenty-nine cognitively normal,...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-014-9329-5

    authors: Schultz SA,Larson J,Oh J,Koscik R,Dowling MN,Gallagher CL,Carlsson CM,Rowley HA,Bendlin BB,Asthana S,Hermann BP,Johnson SC,Sager M,LaRue A,Okonkwo OC

    更新日期:2015-12-01 00:00:00

  • Common and distinct global functional connectivity density alterations in patients with bipolar disorder with and without auditory verbal hallucination during major depressive episodes.

    abstract::Although an increasing number of studies has explored the neural mechanisms of auditory verbal hallucination (AVH) using many modalities, including neuroimaging, neurotransmitters, and electroencephalography, the etiology of AVH remains unclear. In this study, we investigated the neuroimaging characteristics of AVH in...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00222-4

    authors: Qiu L,Ye J,Ji F,Li G,Li G,Ma X,Li R,Tian H,Wang L,Chen G,Xu Y,Wang W,Jiang D,Pan J,Zhuo C

    更新日期:2020-12-01 00:00:00

  • Cerebral changes and cognitive impairment after an ischemic heart disease: a multimodal MRI study.

    abstract::Three to 6 months after an acute coronary syndrome (ACS), cognitive impairment is observed in more than 30 % of the patients, mainly in executive functioning. The aim of this study was to investigate, using multimodal MRI, cerebral anatomo-functional substratum of executive dysfunction. Thirty-three patients were recr...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-015-9483-4

    authors: Bernard C,Catheline G,Dilharreguy B,Couffinhal T,Ledure S,Lassalle-Lagadec S,Callaert D,Allard M,Sibon I

    更新日期:2016-09-01 00:00:00

  • Schizophrenia-related abnormalities in the triple network: a meta-analysis of working memory studies.

    abstract::Previous meta-analyses found abnormal brain activations in schizophrenia patients compared with normal controls when performing working memory tasks. Although most studies focused on dysfunction of the working memory activation network in schizophrenia patients, deactivation abnormalities of the working memory in the ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00071-1

    authors: Wu D,Jiang T

    更新日期:2020-08-01 00:00:00

  • A preliminary report of cerebral white matter microstructural changes associated with adolescent sports concussion acutely and subacutely using diffusion tensor imaging.

    abstract::Diffusion tensor imaging (DTI) has demonstrated its utility in detecting microscopic post-concussion cerebral white matter structural changes, which are not routinely evident on conventional neuroimaging modalities. In this study, we compared 10 adolescents with sports concussion (SC) to 12 orthopedically-injured (OI)...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-017-9752-5

    authors: Wu T,Merkley TL,Wilde EA,Barnes A,Li X,Chu ZD,McCauley SR,Hunter JV,Levin HS

    更新日期:2018-08-01 00:00:00

  • Effects of temporarily disrupting BBB on activity-induced manganese-dependent functional MRI.

    abstract::This study further investigates the influence of temporarily disrupting the blood-brain barrier (BBB) on the level of manganese used in AIM fMRI other than the recognized function of allowing that substance to enter into the activated brain regions more effectively during the BBB opening. We injected manganese into Wi...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-011-9122-7

    authors: Fa Z,Zhang R,Li P,Zhang J,Zhang P,Zhu S,Wu Q,Huang F,Liu Y,Yang L,Chang H,Wen Z,Gao D,Zeng Y,Jiang X

    更新日期:2011-09-01 00:00:00

  • Feeling of presence in dementia with Lewy bodies is related to reduced left frontoparietal metabolism.

    abstract::Feeling of presence (FOP) refers to the vivid sensation of a person's presence near oneself and is common in Dementia with Lewy Bodies (DLB). Based on previous observations on epileptic subjects, we hypothesized that DLB subjects with FOP would harbour 18F-fluorodeoxyglucose PET hypometabolism in left parietal areas. ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9997-7

    authors: Nicastro N,Eger AF,Assal F,Garibotto V

    更新日期:2020-08-01 00:00:00

  • KIBRA polymorphism modulates gray matter volume to influence cognitive ability in the elderly.

    abstract::Genetic variation in the kidney and brain expressed protein (KIBRA) rs17070145 gene has been linked to episodic memory and cognitive aging; yet, the neural mechanism underlying this association remains to be fully understood. Using the magnetic resonance imaging (MRI) technique, this study investigated the effect of K...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00047-1

    authors: Li R,Wan W,Li J

    更新日期:2020-10-01 00:00:00

  • Occipital cortical gyrification reductions associate with decreased functional connectivity in amyotrophic lateral sclerosis.

    abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive muscular weakness and atrophy. Several morphometric studies have been conducted to investigate the gray matter volume or thickness changes in ALS, whereas the cortical folding pattern remains poorly understood. In the...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-015-9499-9

    authors: Zhang Y,Fang T,Wang Y,Guo X,Alarefi A,Wang J,Jiang T,Zhang J

    更新日期:2017-02-01 00:00:00

  • Prospective changes in neural alcohol cue reactivity in at-risk adolescents.

    abstract::Adolescence represents an ideal time for elucidating the etiology of cue reactivity profiles. This study examined the influence of three risk factors consistently associated with heavy adolescent drinking on alcohol cue reactivity. Youth were first assessed while still naïve to alcohol (12-14 years old) and followed a...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-017-9757-0

    authors: Nguyen-Louie TT,Courtney KE,Squeglia LM,Bagot K,Eberson S,Migliorini R,Alcaraz AR,Tapert SF,Pulido C

    更新日期:2018-08-01 00:00:00