Abstract:
:Traumatic brain injury results in a metabolic cascade of changes that occur at the molecular level, invisible to conventional imaging methods such as computed tomography or magnetic resonance imaging. Non-invasive metabolic imaging tools such as single photon emission computed tomography (SPECT), positron emission tomography (PET), and magnetic resonance spectroscopy (MRS) are the ideal methods for providing insight to these changes by measuring regional cerebral blood flow, glucose metabolism, and brain metabolite concentrations, respectively, after mild traumatic brain injury (mTBI). The purpose of this review is to provide an overview of the different methodologies and provide an up-to-date summary of recent findings with SPECT, PET, and MRS technologies, specifically after mTBI, as defined by standardized criteria. Given that the different physiological and pathological responses are heterogeneous, efforts will be made to separate studies at different time points after injury (acute, subacute, and chronic stages) as well as to the different types of mTBI such sports-related head injury where repetitive head injuries are much more common and may present a unique signature.
journal_name
Brain Imaging Behavjournal_title
Brain imaging and behaviorauthors
Lin AP,Liao HJ,Merugumala SK,Prabhu SP,Meehan WP 3rd,Ross BDdoi
10.1007/s11682-012-9181-4subject
Has Abstractpub_date
2012-06-01 00:00:00pages
208-23issue
2eissn
1931-7557issn
1931-7565journal_volume
6pub_type
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