Abstract:
:Primary nocturnal enuresis (PNE) is characterized by a low cure rate and a high reoccurrence rate, since its underlying mechanism remains unclear. Based on the recent studies that thalamus plays an important role in waking up a sleeping person, here we further investigate the functional connectivity (FC) information between thalamus and other brain regions, in order to make better understanding of the PNE's pathogenesis. In this study, we enrolled 30 children diagnosed with PNE and 30 typically developing children that are age and sex matched, the thalamus-based FC estimates were extracted at the resting-state. Experiments showed that for children with PNE, there were four brain regions found with a reduced connection efficiency with thalamus, that were cerebellum posterior lobe, frontal lobe, parietal lobe and precentral gyrus. It can be concluded that these relevant regions might induce an arousal disorder, and therefore further lead to PNE. This finding also provides a new insight in the pathophysiology of PNE.
journal_name
Brain Imaging Behavjournal_title
Brain imaging and behaviorauthors
Zhang A,Zhang L,Wang M,Zhang Y,Jiang F,Jin X,Du X,Ma Jdoi
10.1007/s11682-020-00262-1subject
Has Abstractpub_date
2021-02-01 00:00:00pages
355-363issue
1eissn
1931-7557issn
1931-7565pii
10.1007/s11682-020-00262-1journal_volume
15pub_type
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