Abstract：
:The claustrum is a thin grey matter structure which is involved in a wide brain network. Previous studies suggested a link between claustrum and Parkinson's Disease (PD), showing how α-synuclein pathology may affect claustral neurons as well as how α-synuclein immunoreactivity may correlate with the onset of cognitive dysfunctions. Our aim is to investigate, via diffusion MRI, claustral structural network changes in drug naïve PD patients, with the goal to understand whether such changes may contribute to cognitive decline in PD. 15 drug naïve PD patients and 15 age-matched controls were enrolled; MR protocol was performed on a 3T scanner. Whole brain probabilistic tractography was obtained using Constrained Spherical Deconvolution (CSD) diffusion model. Connectivity matrices were estimated based on a robust anatomical parcellation of structural T1w images. In PD group, impaired subnetworks were correlated with psychological examinations. We found decreased claustral connectivity in PD patients compared to controls, especially with areas mainly involved in visuomotor and attentional systems. Moreover, we found a positive correlation between MoCA and density of pathways connecting ipsilaterally claustrum to left (r = 0.578, p = 0.021) and right (r = 0.640, p = 0.020) Pars Orbitalis. Our results support the hypothesis of claustral involvement in cognitive decline in drug naïve PD patients.
journal_name
Brain Imaging Behavjournal_title
Brain imaging and behaviorauthors
Arrigo A,Calamuneri A,Milardi D,Mormina E,Gaeta M,Corallo F,Lo Buono V,Chillemi G,Marino S,Cacciola A,Di Lorenzo G,Rizzo G,Anastasi GP,Quartarone Adoi
10.1007/s11682-018-9907-zsubject
Has Abstractpub_date
2019-08-01 00:00:00pages
933-944issue
4eissn
1931-7557issn
1931-7565pii
10.1007/s11682-018-9907-zjournal_volume
13pub_type
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