Abstract：
:It has been hypothesized that breast cancer and its chemotherapy can impart functional neural changes via an overlap with biological mechanisms associated with aging. Here we used fMRI to assess whether changes in neural activity accompanying visual episodic memory encoding and retrieval suggest altered activations according to patterns seen in functional imaging of cognitive aging. In a prospective longitudinal design, breast cancer patients (n = 13) were scanned during memory encoding and retrieval before and after chemotherapy treatment, and compared to healthy-age matched controls (n = 13). Our results indicate that despite equivalent behavioral performance, encoding and retrieval resulted in increased activation of prefrontal regions for the breast cancer group compared to controls for both before and after chemotherapy treatment. This was accompanied by decreased activity in posterior brain regions after chemotherapy, particularly those involved in visual processing, for the breast cancer group compared to controls. These findings are discussed as evidence for a possible anterior shift in neural processing to compensate for deficiencies in posterior brain regions, consistent with an accelerated aging account. Cancer and chemotherapy can impact brain regions underlying episodic memory, leading to additional recruitment of control regions, which may be linked to mechanisms related to aging.
journal_name
Brain Imaging Behavjournal_title
Brain imaging and behaviorauthors
Pergolizzi D,Root JC,Pan H,Silbersweig D,Stern E,Passik SD,Ahles TAdoi
10.1007/s11682-019-00038-2subject
Has Abstractpub_date
2019-12-01 00:00:00pages
1674-1688issue
6eissn
1931-7557issn
1931-7565pii
10.1007/s11682-019-00038-2journal_volume
13pub_type
杂志文章abstract：:In conventional resting-state functional MRI (R-fMRI) analysis, functional connectivity is assumed to be temporally stationary, overlooking neural activities or interactions that may happen within the scan duration. Dynamic changes of neural interactions can be reflected by variations of topology and correlation stren...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-015-9408-2
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:Abnormal neural activities during emotional processing have been found in both adults and youths with major depressive disorder. However, findings were inconsistent in each group and cannot be compared to each other. METHODS:We first identified neuroimaging experiments that revealed abnormal neural activiti...
journal_title：Brain imaging and behavior
pub_type： 杂志文章,评审
doi：10.1007/s11682-020-00299-2
更新日期：2020-07-24 00:00:00
abstract：:Face recognition ability varies widely in the normal population and there is increasing interest in linking individual differences in perception to their neural correlates. Such brain-behavior correlations require that both the behavioral measures and the selective BOLD responses be reliable. The reliability of the lo...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-015-9467-4
更新日期：2016-09-01 00:00:00
abstract：:Neuroticism and extraversion are proposed personality dimensions for individual emotion processing. Neuroticism is correlated with depression and anxiety disorders, implicating a common neurobiological basis. Extraversion is rather inversely correlated with anxiety and depression. We examined neural correlates of pers...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-011-9114-7
更新日期：2011-06-01 00:00:00
abstract：:Gyrification of the cortical mantle is a dynamic process that increases with cortical surface area and decreases with age. Increased gyrification is associated with higher scores on cognitive tasks in adults; however, the degree to which this relationship is independent of cortical surface area remains undefined. This...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-017-9696-9
更新日期：2018-04-01 00:00:00
abstract：:Three to 6 months after an acute coronary syndrome (ACS), cognitive impairment is observed in more than 30 % of the patients, mainly in executive functioning. The aim of this study was to investigate, using multimodal MRI, cerebral anatomo-functional substratum of executive dysfunction. Thirty-three patients were recr...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-015-9483-4
更新日期：2016-09-01 00:00:00
abstract：:Gender dysphoria (GD) is characterized by incongruence between one's identity and gender assigned at birth. The biological mechanisms of GD are unclear. We investigated brain network connectivity patterns involved in own body perception in the context of self in GD. Twenty-seven female-to-male (FtM) individuals with G...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-016-9578-6
更新日期：2017-08-01 00:00:00
abstract：:Despite the many studies documenting cerebral white matter microstructural alterations associated with very preterm birth (<32 weeks' gestation), there is a dearth of similar research in moderate and late preterm infants (born 32-36 weeks' gestation), who experience higher rates of neurodevelopmental delays than infan...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-015-9361-0
更新日期：2016-03-01 00:00:00
abstract：:In patients with premotor Huntington's disease (pmHD), literature has reported decreases in caudate volume. However, the regional vulnerability of the caudate nucleus to pmHD remains to be clarified. We aimed to determine whether regional structural damage of the caudate nucleus was present in pmHD and was correlated ...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-016-9616-4
更新日期：2017-10-01 00:00:00
abstract：:The perception of the faces of parents is different from that of other faces. Mother's face perception is associated with childbearing and parenting and has specific cognitive processing properties. Yet, the underlying mechanism remains unknown. We investigated the neural network that is involved in the perception of ...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-015-9486-1
更新日期：2016-12-01 00:00:00
abstract：:Traumatic brain injury results in a metabolic cascade of changes that occur at the molecular level, invisible to conventional imaging methods such as computed tomography or magnetic resonance imaging. Non-invasive metabolic imaging tools such as single photon emission computed tomography (SPECT), positron emission tom...
journal_title：Brain imaging and behavior
pub_type： 杂志文章,评审
doi：10.1007/s11682-012-9181-4
更新日期：2012-06-01 00:00:00
abstract：:The neurobiological mechanisms that underlie facial affect recognition deficits after traumatic brain injury (TBI) have not yet been identified. Using functional magnetic resonance imaging (fMRI), study aims were to 1) determine if there are differences in brain activation during facial affect processing in people wit...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-015-9415-3
更新日期：2016-06-01 00:00:00
abstract：:Thought disorder is considered as one of the core features of schizophrenia and several research groups previously reported an association between P300 (P3b) amplitude and thought disorder in schizophrenia. However, previous studies have not evaluated two P300 subcomponents (P3a and P3b) to investigate whether the rel...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-009-9069-0
更新日期：2009-09-01 00:00:00
abstract：:Resting-state functional MRI (rs-fMRI) has provided important insights into brain physiology. It has become an increasingly popular method for presurgical mapping, as an alternative to task-based functional MRI wherein the subject performs a task while being scanned. However, there is no commonly acknowledged gold sta...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-019-00239-9
更新日期：2021-02-01 00:00:00
abstract：:It is a generally accepted observation that individuals act differently under stress. Recent task-based neuroimaging studies have shown that individuals under stress favor the intuitive and fast system over the deliberative and reflective system. In the present study, using a within-subjects design in thirty young adu...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-018-9898-9
更新日期：2019-06-01 00:00:00
abstract：:Resting state magnetic resonance imaging (rsfMRI) permits observation of intrinsic neural networks produced by task-independent correlations in low frequency brain activity. Various resting state networks have been described, with each thought to reflect common engagement in some shared function. There has been limite...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-017-9771-2
更新日期：2018-08-01 00:00:00
abstract：:Mapping aging-related brain structure and connectivity changes can be helpful for assessing physiological brain age (PBA), which is distinct from chronological age (CA) because genetic and environmental factors affect individuals differently. This study proposes an approach whereby structural and connectomic informati...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-014-9321-0
更新日期：2015-12-01 00:00:00
abstract：:Socioeconomic status (SES) during childhood is a well-documented life-course health determinant. Despite recent advances on characterizing brain structural variance associated with SES during development, how it influences brain's functional organization remains elusive. Associations between SES, an fMRI feature of re...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-019-00073-z
更新日期：2020-08-01 00:00:00
abstract：:Cognitive deficits, especially in the domains of social cognition and executive function including verbal fluency, are common in amyotrophic lateral sclerosis (ALS) patients. There is yet sparse understanding of pathogenesis of the underlying, possibly adaptive, cortical patterns. To address this issue, 65 patients wi...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-017-9738-3
更新日期：2018-06-01 00:00:00
abstract：:Assessing functional brain activation patterns in neuropsychiatric disorders such as cocaine dependence (CD) or pathological gambling (PG) under naturalistic stimuli has received rising interest in recent years. In this paper, we propose and apply a novel group-wise sparse representation framework to assess difference...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-016-9596-4
更新日期：2017-08-01 00:00:00
abstract：:Parkinson's disease (PD) is associated with abnormal synchronization in basal ganglia-thalamo-cortical loops. We tested whether early PD patients without demonstrable cognitive impairment exhibit abnormal modulation of functional connectivity at rest, while engaged in a task, or both. PD and healthy controls underwent...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-014-9317-9
更新日期：2015-09-01 00:00:00
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journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-019-00151-2
更新日期：2020-10-01 00:00:00
abstract：:Altered reward processing and cognitive deficits are often observed in patients with obsessive-compulsive disorder (OCD); however, whether the imbalance in activity between reward circuits and the cognitive control (CC) system is associated with compulsive behavior remains unknown. Sixty-eight OCD patients and 33 cogn...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-016-9585-7
更新日期：2017-08-01 00:00:00
abstract：:Neuroscientific and psychological research posits that there are two transdiagnostic facets of anxiety: anxious arousal and anxious apprehension. Though these two facets of anxiety are distinct, they are often subsumed into one domain (e.g., trait anxiety). The primary goal of the current study was to delineate the re...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-017-9772-1
更新日期：2018-08-01 00:00:00
abstract：:Premenstrual syndrome (PMS) is a menstrual cycle-related disorder. Although the precise pathophysiology is not fully understood, it is increasingly believed that the central nervous system plays a vital role in the development of PMS. The aim of this study is to elucidate specific functional connectivity between the t...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-018-9894-0
更新日期：2019-06-01 00:00:00
abstract：:Neuroimaging studies have implicated abnormal brain microstructure in episodic migraine (EM), but whether the pattern is altered during migraine chronification is not well known. Fifty-six patients with migraine without aura, including 39 EM patients and 17 chronic migraine (CM) patients, and 35 healthy controls (HCs)...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-019-00232-2
更新日期：2021-02-01 00:00:00
abstract：:Dopamine D2 receptors mediate the rewarding effects of many drugs of abuse. In humans, several polymorphisms in DRD2, the gene encoding these receptors, increase our genetic risk for developing addictive disorders. Here, we examined one of the most frequently studied candidate variant for addiction in DRD2 for associa...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-014-9298-8
更新日期：2015-06-01 00:00:00
abstract：:Dislipidemia is a risk factor for cognitive impairment. We studied the association between interindividual variability of plasma lipids and white matter (WM) microstructure, using diffusion tensor imaging (DTI) in 273 healthy adults. Special focus was placed on 7 regions of interest (ROI) which are structural componen...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-020-00311-9
更新日期：2020-08-03 00:00:00
abstract：:There are growing concerns about the generalizability of machine learning classifiers in neuroimaging. In order to evaluate this aspect across relatively large heterogeneous populations, we investigated four disorders: Autism spectrum disorder (N = 988), Attention deficit hyperactivity disorder (N = 930), Post-traumat...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-019-00191-8
更新日期：2020-12-01 00:00:00
abstract：:A left-lateralized fronto-temporo-parietal language network has been well-characterized in adults; however, the neural basis of this fundamental network has hardly been explored in the preschool years, despite this being a time for rapid language development and vocabulary growth. We examined the functional imaging co...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-014-9342-8
更新日期：2015-03-01 00:00:00
