Intrinsic network connectivity and own body perception in gender dysphoria.

Abstract:

:Gender dysphoria (GD) is characterized by incongruence between one's identity and gender assigned at birth. The biological mechanisms of GD are unclear. We investigated brain network connectivity patterns involved in own body perception in the context of self in GD. Twenty-seven female-to-male (FtM) individuals with GD, 27 male controls, and 27 female controls underwent resting state fMRI. We compared functional connections within intrinsic connectivity networks involved in self-referential processes and own body perception -default mode network (DMN) and salience network - and visual networks, using independent components analyses. Behavioral correlates of network connectivity were also tested using self-perception ratings while viewing own body images morphed to their sex assigned at birth, and to the sex of their gender identity. FtM exhibited decreased connectivity of anterior and posterior cingulate and precuneus within the DMN compared with controls. In FtM, higher "self" ratings for bodies morphed towards the sex of their gender identity were associated with greater connectivity of the anterior cingulate within the DMN, during long viewing times. In controls, higher ratings for bodies morphed towards their gender assigned at birth were associated with right insula connectivity within the salience network, during short viewing times. Within visual networks FtM showed weaker connectivity in occipital and temporal regions. Results suggest disconnectivity within networks involved in own body perception in the context of self in GD. Moreover, perception of bodies in relation to self may be reflective rather than reflexive, as a function of mesial prefrontal processes. These may represent neurobiological correlates to the subjective disconnection between perception of body and self-identification.

journal_name

Brain Imaging Behav

authors

Feusner JD,Lidström A,Moody TD,Dhejne C,Bookheimer SY,Savic I

doi

10.1007/s11682-016-9578-6

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

964-976

issue

4

eissn

1931-7557

issn

1931-7565

pii

10.1007/s11682-016-9578-6

journal_volume

11

pub_type

杂志文章
  • Neurophysiological correlates of persistent psycho-affective alterations in athletes with a history of concussion.

    abstract::Understanding the neuropathological underpinnings of sport-related concussion are critical for diagnosis, prognosis, and remediation. Although electro-encephalographic (EEG) methods have proven invaluable for understanding psycho-affective pathologies in various clinical conditions, they have not been used to understa...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-015-9473-6

    authors: Moore RD,Sauve W,Ellemberg D

    更新日期:2016-12-01 00:00:00

  • Abnormal relationships between local and global brain measures in subjects at clinical high risk for psychosis: a pilot study.

    abstract::We examined whether abnormal volumes of several brain regions as well as their mutual associations that have been observed in patients with schizophrenia, are also present in individuals at clinical high-risk (CHR) for developing psychosis. 3T magnetic resonance imaging was acquired in 19 CHR and 20 age- and handednes...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-017-9758-z

    authors: Konishi J,Del Re EC,Bouix S,Blokland GAM,Mesholam-Gately R,Woodberry K,Niznikiewicz M,Goldstein J,Hirayasu Y,Petryshen TL,Seidman LJ,Shenton ME,McCarley RW

    更新日期:2018-08-01 00:00:00

  • Differential dopamine function in fibromyalgia.

    abstract::Approximately 30 % of Americans suffer from chronic pain disorders, such as fibromyalgia (FM), which can cause debilitating pain. Many pain-killing drugs prescribed for chronic pain disorders are highly addictive, have limited clinical efficacy, and do not treat the cognitive symptoms reported by many patients. The ne...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-015-9459-4

    authors: Albrecht DS,MacKie PJ,Kareken DA,Hutchins GD,Chumin EJ,Christian BT,Yoder KK

    更新日期:2016-09-01 00:00:00

  • KIBRA polymorphism modulates gray matter volume to influence cognitive ability in the elderly.

    abstract::Genetic variation in the kidney and brain expressed protein (KIBRA) rs17070145 gene has been linked to episodic memory and cognitive aging; yet, the neural mechanism underlying this association remains to be fully understood. Using the magnetic resonance imaging (MRI) technique, this study investigated the effect of K...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00047-1

    authors: Li R,Wan W,Li J

    更新日期:2020-10-01 00:00:00

  • Altered segregation between task-positive and task-negative regions in mild traumatic brain injury.

    abstract::Changes in large-scale brain networks that accompany mild traumatic brain injury (mTBI) were investigated using functional magnetic resonance imaging (fMRI) during the N-back working memory task at two cognitive loads (1-back and 2-back). Thirty mTBI patients were examined during the chronic stage of injury and compar...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-017-9724-9

    authors: Sours C,Kinnison J,Padmala S,Gullapalli RP,Pessoa L

    更新日期:2018-06-01 00:00:00

  • Participation in cognitively-stimulating activities is associated with brain structure and cognitive function in preclinical Alzheimer's disease.

    abstract::This study tested the hypothesis that frequent participation in cognitively-stimulating activities, specifically those related to playing games and puzzles, is beneficial to brain health and cognition among middle-aged adults at increased risk for Alzheimer's disease (AD). Three hundred twenty-nine cognitively normal,...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-014-9329-5

    authors: Schultz SA,Larson J,Oh J,Koscik R,Dowling MN,Gallagher CL,Carlsson CM,Rowley HA,Bendlin BB,Asthana S,Hermann BP,Johnson SC,Sager M,LaRue A,Okonkwo OC

    更新日期:2015-12-01 00:00:00

  • Source-based morphometry reveals gray matter differences related to suicidal behavior in criminal offenders.

    abstract::Relative to the general population, criminal offenders have a higher risk of suicide. Neurobiological deficits related to suicidal behavior have been identified in the general population, but unexamined in offenders to date. We examined the association between brain morphology and suicidal behavior in adult male crimi...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9957-2

    authors: Harenski CL,Harenski KA,Calhoun VD,Kiehl KA

    更新日期:2020-02-01 00:00:00

  • Variance of the global signal as a pretreatment predictor of antidepressant treatment response in drug-naïve major depressive disorder.

    abstract::Several behavioral and neuroimaging markers could be used to predict eventual antidepressant medication (ADM) outcomes in patients with major depressive disorder (MDD). However, these predictors are either subjective or complex, which has limited their clinical use. Thus, we aimed to identify an objective and easy-to-...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9845-9

    authors: Zhu J,Cai H,Yuan Y,Yue Y,Jiang D,Chen C,Zhang W,Zhuo C,Yu Y

    更新日期:2018-12-01 00:00:00

  • Long-term brain effects of N-back training: an fMRI study.

    abstract::Neurobehavioral effects of cognitive training have become a popular research issue. Specifically, behavioral studies have demonstrated the long-term efficacy of cognitive training of working memory functions, but the neural basis for this training have been studied only at short-term. Using fMRI, we investigate the ce...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9925-x

    authors: Miró-Padilla A,Bueichekú E,Ventura-Campos N,Flores-Compañ MJ,Parcet MA,Ávila C

    更新日期:2019-08-01 00:00:00

  • Uncinate fasciculus microstructure and verbal episodic memory in amyotrophic lateral sclerosis: a diffusion tensor imaging and neuropsychological study.

    abstract::The present study evaluates the integrity of uncinate fasciculus (UF) and the association between UF microstructure and verbal episodic memory (as one of the cognitive functions linked to UF) in non-demented patients with amyotrophic lateral sclerosis (ALS) using diffusion tensor imaging (DTI). We studied 21 patients ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-013-9271-y

    authors: Christidi F,Zalonis I,Kyriazi S,Rentzos M,Karavasilis E,Wilde EA,Evdokimidis I

    更新日期:2014-12-01 00:00:00

  • Failing compensatory mechanisms during working memory in older apolipoprotein E-epsilon4 healthy adults.

    abstract::How and when the known genetic risk allele, apolipoprotein E-epsilon4 (APOEepsilon4), confers risk to Alzheimer's disease has yet to be determined. We studied older adults and found that APOEepsilon4 carriers had greater neural activation in the medial frontal and parahippocampal gyrus during a memory task (cluster-co...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-010-9097-9

    authors: Filbey FM,Chen G,Sunderland T,Cohen RM

    更新日期:2010-06-01 00:00:00

  • Endocytosis-pathway polygenic scores affects the hippocampal network connectivity and individualized identification across the high-risk of Alzheimer's disease.

    abstract::The neural mechanisms underlying the polygenic effects of the endocytosis pathway on the brain function of Alzheimer's Disease (AD) remain unclear, especially in the prodromal stages of AD from early mild cognitive impairment (EMCI) to late mild cognitive impairment (LMCI). We used an imaging genetic approach to inves...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-020-00316-4

    authors: Zhu Y,Zang F,Liu X,Fan D,Zhang Q,Ren Q,Xie C,Alzheimer’s Disease Neuroimaging Initiative.

    更新日期:2020-08-16 00:00:00

  • Extra-motor cerebral changes and manifestations in primary lateral sclerosis.

    abstract::Primary lateral sclerosis (PLS) is classically considered a 'pure' upper motor neuron disorder. Motor cortex atrophy and pyramidal tract degeneration are thought to be pathognomonic of PLS, but extra-motor cerebral changes are poorly characterized. In a prospective neuroimaging study, forty PLS patients were systemati...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-020-00421-4

    authors: Finegan E,Shing SLH,Chipika RH,Chang KM,McKenna MC,Doherty MA,Hengeveld JC,Vajda A,Pender N,Donaghy C,Hutchinson S,McLaughlin RL,Hardiman O,Bede P

    更新日期:2021-01-07 00:00:00

  • Headache frequency associates with brain microstructure changes in patients with migraine without aura.

    abstract::Neuroimaging studies have implicated abnormal brain microstructure in episodic migraine (EM), but whether the pattern is altered during migraine chronification is not well known. Fifty-six patients with migraine without aura, including 39 EM patients and 17 chronic migraine (CM) patients, and 35 healthy controls (HCs)...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00232-2

    authors: Yu Y,Zhao H,Dai L,Su Y,Wang X,Chen C,Shang Y,Ke J,Hu C

    更新日期:2021-02-01 00:00:00

  • Episodic memory for visual scenes suggests compensatory brain activity in breast cancer patients: a prospective longitudinal fMRI study.

    abstract::It has been hypothesized that breast cancer and its chemotherapy can impart functional neural changes via an overlap with biological mechanisms associated with aging. Here we used fMRI to assess whether changes in neural activity accompanying visual episodic memory encoding and retrieval suggest altered activations ac...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00038-2

    authors: Pergolizzi D,Root JC,Pan H,Silbersweig D,Stern E,Passik SD,Ahles TA

    更新日期:2019-12-01 00:00:00

  • Association Study between Auditory P3a/P3b Event-Related Potentials and Thought Disorder in Schizophrenia.

    abstract::Thought disorder is considered as one of the core features of schizophrenia and several research groups previously reported an association between P300 (P3b) amplitude and thought disorder in schizophrenia. However, previous studies have not evaluated two P300 subcomponents (P3a and P3b) to investigate whether the rel...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-009-9069-0

    authors: Kirihara K,Araki T,Uetsuki M,Yamasue H,Hata A,Rogers MA,Iwanami A,Kasai K

    更新日期:2009-09-01 00:00:00

  • The dissociative subtype of posttraumatic stress disorder is associated with subcortical white matter network alterations.

    abstract::Posttraumatic stress disorder (PTSD) is characterized by intrusions, avoidance, and hyperarousal while patients of the dissociative subtype (PTSD-D) experience additional dissociative symptoms. A neurobiological model proposes hyper-inhibition of limbic structures mediated by prefrontal cortices to underlie dissociati...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-020-00274-x

    authors: Sierk A,Manthey A,Brakemeier EL,Walter H,Daniels JK

    更新日期:2020-04-27 00:00:00

  • The relationship between microvasculature in white matter hyperintensities and cognitive function.

    abstract::White matter hyperintensities (WMHs) are associated with cognitive decline, but less is known about pathophysiology of cognitive decline in patients with WMHs. We investigated microvasculature and microstructure in WMHs using intravoxel incoherent motion (IVIM) and their associations with cognitive function. Thirty-tw...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-016-9531-8

    authors: Sun J,Yu X,Jiaerken Y,Song R,Huang P,Wang C,Yuan L,Mao Y,Guo Y,Yu H,Zhang M

    更新日期:2017-04-01 00:00:00

  • Effects of an ambient odor on brain activations during episodic retrieval of objects.

    abstract::This study investigated the brain areas involved in episodic memory retrieval of pictures depending on the characteristics of the contextual environment during encoding (i.e. presence or absence of an odor). In the first stage, subjects were presented with a series of 32 pictures. Half of the pictures were presented w...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-012-9218-8

    authors: Galliot E,Comte A,Magnin E,Tatu L,Moulin T,Millot JL

    更新日期:2013-06-01 00:00:00

  • Revealing the multisensory modulation of auditory stimulus in degraded visual object recognition by dynamic causal modeling.

    abstract::Recent evidence from neurophysiological and functional imaging research has demonstrated that semantically congruent sounds can modulate the identification of a degraded visual object. However, it remains unclear how different integration regions interact with each other when only a visual object was obscured. The pre...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00134-3

    authors: Lu L,Liu B

    更新日期:2020-08-01 00:00:00

  • Recognition of faces and names: multimodal physiological correlates of memory and executive function.

    abstract::We sought to characterize electrophysiological, eye-tracking and behavioral correlates of face-name recognition memory in healthy younger adults using high-density electroencephalography (EEG), infrared eye-tracking (ET), and neuropsychological measures. Twenty-one participants first studied 40 face-name (FN) pairs; 2...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-015-9420-6

    authors: Mitchell MB,Shirk SD,McLaren DG,Dodd JS,Ezzati A,Ally BA,Atri A

    更新日期:2016-06-01 00:00:00

  • Schizophrenia-related abnormalities in the triple network: a meta-analysis of working memory studies.

    abstract::Previous meta-analyses found abnormal brain activations in schizophrenia patients compared with normal controls when performing working memory tasks. Although most studies focused on dysfunction of the working memory activation network in schizophrenia patients, deactivation abnormalities of the working memory in the ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00071-1

    authors: Wu D,Jiang T

    更新日期:2020-08-01 00:00:00

  • Occipital cortical gyrification reductions associate with decreased functional connectivity in amyotrophic lateral sclerosis.

    abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive muscular weakness and atrophy. Several morphometric studies have been conducted to investigate the gray matter volume or thickness changes in ALS, whereas the cortical folding pattern remains poorly understood. In the...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-015-9499-9

    authors: Zhang Y,Fang T,Wang Y,Guo X,Alarefi A,Wang J,Jiang T,Zhang J

    更新日期:2017-02-01 00:00:00

  • Altered regional brain volumes in elderly carriers of a risk variant for drug abuse in the dopamine D2 receptor gene (DRD2).

    abstract::Dopamine D2 receptors mediate the rewarding effects of many drugs of abuse. In humans, several polymorphisms in DRD2, the gene encoding these receptors, increase our genetic risk for developing addictive disorders. Here, we examined one of the most frequently studied candidate variant for addiction in DRD2 for associa...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-014-9298-8

    authors: Roussotte FF,Jahanshad N,Hibar DP,Thompson PM,Alzheimer’s Disease Neuroimaging Initiative (ADNI).

    更新日期:2015-06-01 00:00:00

  • Only-child and non-only-child exhibit differences in creativity and agreeableness: evidence from behavioral and anatomical structural studies.

    abstract::Different family composition and size inevitably make only-children different from non-only-children. Previous studies have focused on the differences in behaviors, such as cognitive function and personality traits, between the only-child and the non-only-child. However, there are few studies that have focused on the ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-016-9530-9

    authors: Yang J,Hou X,Wei D,Wang K,Li Y,Qiu J

    更新日期:2017-04-01 00:00:00

  • Recruitment and stabilization of brain activation within a working memory task; an FMRI study.

    abstract::Seventeen subjects underwent functional magnetic resonance imaging (fMRI) performing a 2-Back verbal working memory (VWM) task alternating with a control task to characterize the temporal dynamics of the specific brain regions involved in VWM. Serial sampling of 2-Back sub-blocks revealed many small areas of activatio...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-009-9081-4

    authors: Paskavitz JF,Sweet LH,Wellen J,Helmer KG,Rao SM,Cohen RA

    更新日期:2010-03-01 00:00:00

  • Gut dysbiosis-influence on amygdala-based functional activity in patients with end stage renal disease: a preliminary study.

    abstract::Patients with end-stage renal disease (ESRD) are notably accompanied by cognitive disorder and anxiety or depressive symptom. We aimed to explore the linkages of the amygdala-based MR parameters, cognitive and mood performance, systematic inflammation and gut microbiota in ESRD. This prospective study enrolled 28 ESRD...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00223-3

    authors: Zheng LJ,Lin L,Zhong J,Zhang Z,Ye YB,Zhang XY,Wang YF,Zhang H,Liu Y,Lu GM,Gong D,Zhang LJ

    更新日期:2020-12-01 00:00:00

  • Neural correlates of personality dimensions and affective measures during the anticipation of emotional stimuli.

    abstract::Neuroticism and extraversion are proposed personality dimensions for individual emotion processing. Neuroticism is correlated with depression and anxiety disorders, implicating a common neurobiological basis. Extraversion is rather inversely correlated with anxiety and depression. We examined neural correlates of pers...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-011-9114-7

    authors: Brühl AB,Viebke MC,Baumgartner T,Kaffenberger T,Herwig U

    更新日期:2011-06-01 00:00:00

  • Early effects of a high-caloric diet and physical exercise on brain volumetry and behavior: a combined MRI and histology study in mice.

    abstract::Excessive intake of high-caloric diets as well as subsequent development of obesity and diabetes mellitus may exert a wide range of unfavorable effects on the central nervous system (CNS) in the long-term. The potentially harmful effects of such diets were suggested to be mitigated by physical exercise. Here, we condu...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-016-9638-y

    authors: Sack M,Lenz JN,Jakovcevski M,Biedermann SV,Falfán-Melgoza C,Deussing J,Bielohuby M,Bidlingmaier M,Pfister F,Stalla GK,Sartorius A,Gass P,Weber-Fahr W,Fuss J,Auer MK

    更新日期:2017-10-01 00:00:00

  • Comparison of ApoE-related brain connectivity differences in early MCI and normal aging populations: an fMRI study.

    abstract::In this study, we used resting-state functional magnetic resonance imaging (rs-fMRI) scans from subjects with early mild cognitive impairment (EMCI) and control subjects to study functional network connectivity. The scans were acquired by the Alzheimer's Disease Neuroimaging Initiative (ADNI). We used genetic data fro...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-015-9451-z

    authors: McKenna F,Koo BB,Killiany R,Alzheimer’s Disease Neuroimaging Initiative.

    更新日期:2016-12-01 00:00:00