Differential dopamine function in fibromyalgia.

Abstract:

:Approximately 30 % of Americans suffer from chronic pain disorders, such as fibromyalgia (FM), which can cause debilitating pain. Many pain-killing drugs prescribed for chronic pain disorders are highly addictive, have limited clinical efficacy, and do not treat the cognitive symptoms reported by many patients. The neurobiological substrates of chronic pain are largely unknown, but evidence points to altered dopaminergic transmission in aberrant pain perception. We sought to characterize the dopamine (DA) system in individuals with FM. Positron emission tomography (PET) with [(18)F]fallypride (FAL) was used to assess changes in DA during a working memory challenge relative to a baseline task, and to test for associations between baseline D2/D3 availability and experimental pain measures. Twelve female subjects with FM and 11 female controls completed study procedures. Subjects received one FAL PET scan while performing a "2-back" task, and one while performing a "0-back" (attentional control, "baseline") task. FM subjects had lower baseline FAL binding potential (BP) in several cortical regions relative to controls, including anterior cingulate cortex. In FM subjects, self-reported spontaneous pain negatively correlated with FAL BP in the left orbitofrontal cortex and parahippocampal gyrus. Baseline BP was significantly negatively correlated with experimental pain sensitivity and tolerance in both FM and CON subjects, although spatial patterns of these associations differed between groups. The data suggest that abnormal DA function may be associated with differential processing of pain perception in FM. Further studies are needed to explore the functional significance of DA in nociception and cognitive processing in chronic pain.

journal_name

Brain Imaging Behav

authors

Albrecht DS,MacKie PJ,Kareken DA,Hutchins GD,Chumin EJ,Christian BT,Yoder KK

doi

10.1007/s11682-015-9459-4

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

829-39

issue

3

eissn

1931-7557

issn

1931-7565

pii

10.1007/s11682-015-9459-4

journal_volume

10

pub_type

杂志文章
  • Structural covariance mapping delineates medial and medio-lateral temporal networks in déjà vu.

    abstract::Déjà vu (DV) is an eerie phenomenon experienced frequently as an aura of temporal lobe epilepsy, but also reported commonly by healthy individuals. The former pathological manifestation appears to result from aberrant neural activity among brain structures within the medial temporal lobes. Recent studies also implicat...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-015-9471-8

    authors: Shaw DJ,Mareček R,Brázdil M

    更新日期:2016-12-01 00:00:00

  • Failing compensatory mechanisms during working memory in older apolipoprotein E-epsilon4 healthy adults.

    abstract::How and when the known genetic risk allele, apolipoprotein E-epsilon4 (APOEepsilon4), confers risk to Alzheimer's disease has yet to be determined. We studied older adults and found that APOEepsilon4 carriers had greater neural activation in the medial frontal and parahippocampal gyrus during a memory task (cluster-co...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-010-9097-9

    authors: Filbey FM,Chen G,Sunderland T,Cohen RM

    更新日期:2010-06-01 00:00:00

  • Sparse temporally dynamic resting-state functional connectivity networks for early MCI identification.

    abstract::In conventional resting-state functional MRI (R-fMRI) analysis, functional connectivity is assumed to be temporally stationary, overlooking neural activities or interactions that may happen within the scan duration. Dynamic changes of neural interactions can be reflected by variations of topology and correlation stren...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-015-9408-2

    authors: Wee CY,Yang S,Yap PT,Shen D,Alzheimer’s Disease Neuroimaging Initiative.

    更新日期:2016-06-01 00:00:00

  • Source-based morphometry reveals gray matter differences related to suicidal behavior in criminal offenders.

    abstract::Relative to the general population, criminal offenders have a higher risk of suicide. Neurobiological deficits related to suicidal behavior have been identified in the general population, but unexamined in offenders to date. We examined the association between brain morphology and suicidal behavior in adult male crimi...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9957-2

    authors: Harenski CL,Harenski KA,Calhoun VD,Kiehl KA

    更新日期:2020-02-01 00:00:00

  • Relationship between receptive vocabulary and the neural substrates for story processing in preschoolers.

    abstract::A left-lateralized fronto-temporo-parietal language network has been well-characterized in adults; however, the neural basis of this fundamental network has hardly been explored in the preschool years, despite this being a time for rapid language development and vocabulary growth. We examined the functional imaging co...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-014-9342-8

    authors: Sroka MC,Vannest J,Maloney TC,Horowitz-Kraus T,Byars AW,Holland SK,CMIND Authorship Consortium.

    更新日期:2015-03-01 00:00:00

  • Correction to: Interactive mapping of language and memory with the GE2REC protocol.

    abstract::The article Interactive mapping of language and memory with the GE2REC protocol, written by Sonja Banjac, Elise Roger, Emilie Cousin, Marcela Perrone-Bertolotti, Célise Haldin, Cédric Pichat, Laurent Lamalle, Lorella Minotti, Philippe Kahane, and Monica Baciu was originally published electronically on the publisher's ...

    journal_title:Brain imaging and behavior

    pub_type: 已发布勘误

    doi:10.1007/s11682-020-00403-6

    authors: Banjac S,Roger E,Cousin E,Perrone-Bertolotti M,Haldin C,Pichat C,Lamalle L,Minotti L,Kahane P,Baciu M

    更新日期:2020-10-01 00:00:00

  • Imbalanced functional link between reward circuits and the cognitive control system in patients with obsessive-compulsive disorder.

    abstract::Altered reward processing and cognitive deficits are often observed in patients with obsessive-compulsive disorder (OCD); however, whether the imbalance in activity between reward circuits and the cognitive control (CC) system is associated with compulsive behavior remains unknown. Sixty-eight OCD patients and 33 cogn...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-016-9585-7

    authors: Xie C,Ma L,Jiang N,Huang R,Li L,Gong L,He C,Xiao C,Liu W,Xu S,Zhang Z

    更新日期:2017-08-01 00:00:00

  • Functional connectivity of posterior cingulate gyrus in heroin dependents treated by methadone maintenance and protracted abstinence measures: an event-related fMRI study.

    abstract::Protracted abstinence (PA) and Methadone maintenance treatment (MMT) are two main types of heroin addiction treatment, however, the effects of both measures on the functional connectivity (FC) of the brain in heroin dependents in the drug cue event-related response are unclear. Functional magnetic resonance imaging (f...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-020-00447-8

    authors: Wei X,Chen J,Zhu J,Li Q,Li W,Wang W

    更新日期:2021-01-27 00:00:00

  • Diffusion tensor imaging and magnetic resonance spectroscopy in traumatic brain injury: a review of recent literature.

    abstract::Concussion is the most common form of traumatic brain injury (TBI), but diagnosis remains controversial because the brain appears quite normal in conventional computed tomography and magnetic resonance imaging (MRI). These conventional tools are not sensitive enough to detect diffuse traumatic axonal injury, and canno...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章,评审

    doi:10.1007/s11682-013-9288-2

    authors: Xiong KL,Zhu YS,Zhang WG

    更新日期:2014-12-01 00:00:00

  • Regional entropy of functional imaging signals varies differently in sensory and cognitive systems during propofol-modulated loss and return of behavioral responsiveness.

    abstract::The level and richness of consciousness depend on information integration in the brain. Altered interregional functional interactions may indicate disrupted information integration during anesthetic-induced unconsciousness. How anesthetics modulate the amount of information in various brain regions has received less a...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9886-0

    authors: Liu X,Lauer KK,Ward BD,Roberts CJ,Liu S,Gollapudy S,Rohloff R,Gross W,Xu Z,Chen S,Wang L,Yang Z,Li SJ,Binder JR,Hudetz AG

    更新日期:2019-04-01 00:00:00

  • Gut dysbiosis-influence on amygdala-based functional activity in patients with end stage renal disease: a preliminary study.

    abstract::Patients with end-stage renal disease (ESRD) are notably accompanied by cognitive disorder and anxiety or depressive symptom. We aimed to explore the linkages of the amygdala-based MR parameters, cognitive and mood performance, systematic inflammation and gut microbiota in ESRD. This prospective study enrolled 28 ESRD...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00223-3

    authors: Zheng LJ,Lin L,Zhong J,Zhang Z,Ye YB,Zhang XY,Wang YF,Zhang H,Liu Y,Lu GM,Gong D,Zhang LJ

    更新日期:2020-12-01 00:00:00

  • Surface-based morphometry reveals caudate subnuclear structural damage in patients with premotor Huntington disease.

    abstract::In patients with premotor Huntington's disease (pmHD), literature has reported decreases in caudate volume. However, the regional vulnerability of the caudate nucleus to pmHD remains to be clarified. We aimed to determine whether regional structural damage of the caudate nucleus was present in pmHD and was correlated ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-016-9616-4

    authors: Kim H,Kim JH,Possin KL,Winer J,Geschwind MD,Xu D,Hess CP

    更新日期:2017-10-01 00:00:00

  • Effects of an ambient odor on brain activations during episodic retrieval of objects.

    abstract::This study investigated the brain areas involved in episodic memory retrieval of pictures depending on the characteristics of the contextual environment during encoding (i.e. presence or absence of an odor). In the first stage, subjects were presented with a series of 32 pictures. Half of the pictures were presented w...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-012-9218-8

    authors: Galliot E,Comte A,Magnin E,Tatu L,Moulin T,Millot JL

    更新日期:2013-06-01 00:00:00

  • Abnormal white matter tracts of insula in smokers.

    abstract::Nicotine addiction is characterized as a neural circuit dysfunction, particularly with regard to the alterations in central reward pathways. The insula, a cortical region that is thought to play a central role in this reward circuitry, has been implicated in the maintenance of nicotine addiction. However, it remains l...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-020-00389-1

    authors: Wang C,Wang S,Huang P,Shen Z,Qian W,Luo X,Li K,Zeng Q,Gu Q,Yu H,Yang Y,Zhang M

    更新日期:2020-09-24 00:00:00

  • Variance of the global signal as a pretreatment predictor of antidepressant treatment response in drug-naïve major depressive disorder.

    abstract::Several behavioral and neuroimaging markers could be used to predict eventual antidepressant medication (ADM) outcomes in patients with major depressive disorder (MDD). However, these predictors are either subjective or complex, which has limited their clinical use. Thus, we aimed to identify an objective and easy-to-...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9845-9

    authors: Zhu J,Cai H,Yuan Y,Yue Y,Jiang D,Chen C,Zhang W,Zhuo C,Yu Y

    更新日期:2018-12-01 00:00:00

  • Disruption of functional connectivity among subcortical arousal system and cortical networks in temporal lobe epilepsy.

    abstract::Growing evidence has demonstrated widespread brain network alterations in temporal lobe epilepsy (TLE). However, the relatively accurate portrait of the subcortical-cortical relationship for impaired consciousness in TLE remains unclear. We proposed that consciousness-impairing seizures may invade subcortical arousal ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-0014-y

    authors: Li R,Hu C,Wang L,Liu D,Liu D,Liao W,Xiao B,Chen H,Feng L

    更新日期:2020-06-01 00:00:00

  • Coordinated brain development: exploring the synchrony between changes in grey and white matter during childhood maturation.

    abstract::Brain development during childhood and early adolescence is characterized by global changes in brain architecture. Neuroimaging studies have revealed overall decreases in cortical thickness (CT) and increases in fractional anisotropy (FA). Furthermore, previous studies have shown that certain cortical regions display ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-016-9555-0

    authors: Moura LM,Crossley NA,Zugman A,Pan PM,Gadelha A,Del Aquilla MAG,Picon FA,Anés M,Amaro E Jr,de Jesus Mari J,Miguel EC,Rohde LA,Bressan RA,McGuire P,Sato JR,Jackowski AP

    更新日期:2017-06-01 00:00:00

  • Participation in cognitively-stimulating activities is associated with brain structure and cognitive function in preclinical Alzheimer's disease.

    abstract::This study tested the hypothesis that frequent participation in cognitively-stimulating activities, specifically those related to playing games and puzzles, is beneficial to brain health and cognition among middle-aged adults at increased risk for Alzheimer's disease (AD). Three hundred twenty-nine cognitively normal,...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-014-9329-5

    authors: Schultz SA,Larson J,Oh J,Koscik R,Dowling MN,Gallagher CL,Carlsson CM,Rowley HA,Bendlin BB,Asthana S,Hermann BP,Johnson SC,Sager M,LaRue A,Okonkwo OC

    更新日期:2015-12-01 00:00:00

  • Intrinsic network connectivity and own body perception in gender dysphoria.

    abstract::Gender dysphoria (GD) is characterized by incongruence between one's identity and gender assigned at birth. The biological mechanisms of GD are unclear. We investigated brain network connectivity patterns involved in own body perception in the context of self in GD. Twenty-seven female-to-male (FtM) individuals with G...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-016-9578-6

    authors: Feusner JD,Lidström A,Moody TD,Dhejne C,Bookheimer SY,Savic I

    更新日期:2017-08-01 00:00:00

  • Quantitative prediction of individual cognitive flexibility using structural MRI.

    abstract::Cognitive flexibility, a core dimension of executive functions, refers to one's ability to switch between multiple tasks and sets in a quick and flexible manner. However, whether objective neuroimaging can be used to quantitatively predict cognitive flexibility at the individual level remains largely unexplored. High-...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9905-1

    authors: Zhu J,Zhu DM,Zhang C,Wang Y,Yang Y,Yu Y

    更新日期:2019-06-01 00:00:00

  • Aerobic exercise increases hippocampal subfield volumes in younger adults and prevents volume decline in the elderly.

    abstract::Exercise improves both physical and mental health and increases neurogenesis in the dendate gyrus (DG) of the hippocampus. The aim of this study was to examine whether exercising, as compared to no change in regular physical activity, would impact on hippocampal volume, and in particular the core hippocampal structure...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00088-6

    authors: Frodl T,Strehl K,Carballedo A,Tozzi L,Doyle M,Amico F,Gormley J,Lavelle G,O'Keane V

    更新日期:2020-10-01 00:00:00

  • Altered regional homogeneity in pediatric bipolar disorder during manic and euthymic state: a resting-state fMRI study.

    abstract::Pediatric bipolar disorder (PBD) is a severely debilitating illness, which is characterized by episodes of mania and depression separated by periods of remission. Little is known about the abnormalities in PBD in resting state, especially comparing manic with euthymic state. Resting state brain activity measured by fM...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00117-4

    authors: Xiao Q,Cui D,Jiao Q,Zhong Y,Cao W,Lu G,Su L

    更新日期:2019-12-01 00:00:00

  • Parieto-frontal gyrification and working memory in healthy adults.

    abstract::Gyrification of the cortical mantle is a dynamic process that increases with cortical surface area and decreases with age. Increased gyrification is associated with higher scores on cognitive tasks in adults; however, the degree to which this relationship is independent of cortical surface area remains undefined. This...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-017-9696-9

    authors: Green S,Blackmon K,Thesen T,DuBois J,Wang X,Halgren E,Devinsky O

    更新日期:2018-04-01 00:00:00

  • Effects of age, sex, and puberty on neural efficiency of cognitive and motor control in adolescents.

    abstract::Critical changes in adolescence involve brain cognitive maturation of inhibitory control processes that are essential for a myriad of adult functions. Cognitive control advances into adulthood as there is more flexible integration of component processes, including inhibitory control of conflicting information, overwri...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00075-x

    authors: Schulte T,Hong JY,Sullivan EV,Pfefferbaum A,Baker FC,Chu W,Prouty D,Kwon D,Meloy MJ,Brumback T,Tapert SF,Colrain IM,Müller-Oehring EM

    更新日期:2020-08-01 00:00:00

  • Brain volumes in adults with congenital heart disease correlate with executive function abilities.

    abstract::Congenital heart disease is the most common birth defect, and patients are at risk for neurodevelopmental impairment and brain abnormalities. Yet, little is known about the link between brain volumes and cognitive function in adults with congenital heart disease. Forty-four patients and 53 controls between 18 and 32 y...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-020-00424-1

    authors: Naef N,Schlosser L,Brugger P,Greutmann M,Oxenius A,Wehrle F,Kottke R,Latal B,O'Gorman RT

    更新日期:2021-01-30 00:00:00

  • The variation of motor-related brain structure and its relation to abnormal motor behaviors in end-stage renal disease patients with restless legs syndrome.

    abstract::Restless legs syndrome (RLS) is common in the end-stage renal disease (ESRD) population; however, their interrelationship remains largely unclear. In the current study, we aimed to investigate the brain structure variation in ESRD patients with RLS (ERSD-RLS) and its potential relation with the severity of RLS. Diffus...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9968-z

    authors: Mu J,Liu X,Ma S,Chen T,Ma X,Li P,Ding D,Liu J,Zhang M

    更新日期:2020-02-01 00:00:00

  • Diffusion MRI as a complementary assessment to cognition, emotion, and motor dysfunction after sports-related concussion: a systematic review and critical appraisal of the literature.

    abstract::Sports-related concussion (SRC) is a complex and heterogeneous injury with psychological, cognitive and functional consequences. Advances in diffusion magnetic resonance imaging (dMRI) allow sensitive measurement of white matter pathology post-SRC and may provide insight into injury and recovery. We systematically rev...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章,评审

    doi:10.1007/s11682-020-00336-0

    authors: Hellewell SC,Welton T,Pearce AJ,Maller JJ,Grieve SM

    更新日期:2020-07-27 00:00:00

  • Exposure to childhood trauma is associated with altered n-back activation and performance in healthy adults: implications for a commonly used working memory task.

    abstract::Previous research suggests that a history of early life stress (ELS) impacts working memory (WM) in adulthood. Despite the widespread use of WM paradigms, few studies have evaluated whether ELS exposure, in the absence of psychiatric illness, also impacts WM-associated brain activity in ways that might improve sensiti...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-015-9373-9

    authors: Philip NS,Sweet LH,Tyrka AR,Carpenter SL,Albright SE,Price LH,Carpenter LL

    更新日期:2016-03-01 00:00:00

  • Cerebral changes and cognitive impairment after an ischemic heart disease: a multimodal MRI study.

    abstract::Three to 6 months after an acute coronary syndrome (ACS), cognitive impairment is observed in more than 30 % of the patients, mainly in executive functioning. The aim of this study was to investigate, using multimodal MRI, cerebral anatomo-functional substratum of executive dysfunction. Thirty-three patients were recr...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-015-9483-4

    authors: Bernard C,Catheline G,Dilharreguy B,Couffinhal T,Ledure S,Lassalle-Lagadec S,Callaert D,Allard M,Sibon I

    更新日期:2016-09-01 00:00:00

  • Acute social stress modulates coherence regional homogeneity.

    abstract::It is a generally accepted observation that individuals act differently under stress. Recent task-based neuroimaging studies have shown that individuals under stress favor the intuitive and fast system over the deliberative and reflective system. In the present study, using a within-subjects design in thirty young adu...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9898-9

    authors: Chang J,Yu R

    更新日期:2019-06-01 00:00:00