Abstract:
:The level and richness of consciousness depend on information integration in the brain. Altered interregional functional interactions may indicate disrupted information integration during anesthetic-induced unconsciousness. How anesthetics modulate the amount of information in various brain regions has received less attention. Here, we propose a novel approach to quantify regional information content in the brain by the entropy of the principal components of regional blood oxygen-dependent imaging signals during graded propofol sedation. Fifteen healthy individuals underwent resting-state scans in wakeful baseline, light sedation (conscious), deep sedation (unconscious), and recovery (conscious). Light sedation characterized by lethargic behavioral responses was associated with global reduction of entropy in the brain. Deep sedation with completely suppressed overt responsiveness was associated with further reductions of entropy in sensory (primary and higher sensory plus orbital prefrontal cortices) but not high-order cognitive (dorsal and medial prefrontal, cingulate, parietotemporal cortices and hippocampal areas) systems. Upon recovery of responsiveness, entropy was restored in the sensory but not in high-order cognitive systems. These findings provide novel evidence for a reduction of information content of the brain as a potential systems-level mechanism of reduced consciousness during propofol anesthesia. The differential changes of entropy in the sensory and high-order cognitive systems associated with losing and regaining overt responsiveness are consistent with the notion of "disconnected consciousness", in which a complete sensory-motor disconnection from the environment occurs with preserved internal mentation.
journal_name
Brain Imaging Behavjournal_title
Brain imaging and behaviorauthors
Liu X,Lauer KK,Ward BD,Roberts CJ,Liu S,Gollapudy S,Rohloff R,Gross W,Xu Z,Chen S,Wang L,Yang Z,Li SJ,Binder JR,Hudetz AGdoi
10.1007/s11682-018-9886-0subject
Has Abstractpub_date
2019-04-01 00:00:00pages
514-525issue
2eissn
1931-7557issn
1931-7565pii
10.1007/s11682-018-9886-0journal_volume
13pub_type
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