Executive functional deficits during electrical stimulation of the right frontal aslant tract.

Abstract:

:Direct electrical stimulation mapping was used to map executive functions during awake surgery of a patient with a right frontal low-grade glioma. We specifically targeted the frontal aslant tract, as this pathway had been infiltrated by the tumor. The right frontal aslant tract has been implicated in executive functions in the neuroscientific literature, but is yet of unknown relevance for clinical practice. Guided by tractography, electrical stimulation of the frontal aslant tract disrupted working memory and inhibitory functions. In this report we illustrate the dilemmas that neurosurgeons face when balancing maximal tumor resection against optimal cognitive performance. In particular, we emphasize that intraoperative tasks that target cognitive functions should be carefully introduced in clinical practice to prevent clinically irrelevant responses and too early termination of the resection.

journal_name

Brain Imaging Behav

authors

Rutten GM,Landers MJF,De Baene W,Meijerink T,van der Hek S,Verheul JHB

doi

10.1007/s11682-020-00439-8

subject

Has Abstract

pub_date

2021-01-19 00:00:00

eissn

1931-7557

issn

1931-7565

pii

10.1007/s11682-020-00439-8

pub_type

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