Comparison of ApoE-related brain connectivity differences in early MCI and normal aging populations: an fMRI study.

Abstract:

:In this study, we used resting-state functional magnetic resonance imaging (rs-fMRI) scans from subjects with early mild cognitive impairment (EMCI) and control subjects to study functional network connectivity. The scans were acquired by the Alzheimer's Disease Neuroimaging Initiative (ADNI). We used genetic data from the ADNI database to further subdivide the EMCI and control groups into genotype groups with or without the Apolipoprotein E allele e4 (APOE e4). Region of interest (ROI)-to-ROI resting-state functional connectivity was measured using Freesurfer and the Functional Connectivity Toolbox for Matlab (CONN). In our analysis, we compared whole-brain ROI connectivity strength and ROI-to-ROI functional network connectivity strength between EMCI, control and genotype subject groups. We found that the ROI network properties were disrupted in EMCI and APOE e4 carrier groups. Notably, we show that (1) EMCI disrupts functional connectivity strength in many important functionally-linked areas; (2) APOE e4 disrupts functional connectivity strength in similar areas to EMCI; and (3) the differences in functional connectivity between groups shows a multifactor contribution to functional network dysfunction along the trajectory leading to dementia.

journal_name

Brain Imaging Behav

authors

McKenna F,Koo BB,Killiany R,Alzheimer’s Disease Neuroimaging Initiative.

doi

10.1007/s11682-015-9451-z

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

970-983

issue

4

eissn

1931-7557

issn

1931-7565

pii

10.1007/s11682-015-9451-z

journal_volume

10

pub_type

杂志文章
  • A systematic review of associations between functional MRI activity and polygenic risk for schizophrenia and bipolar disorder.

    abstract::Genetic factors account for up to 80% of the liability for schizophrenia (SCZ) and bipolar disorder (BD). Genome-wide association studies have successfully identified several genes associated with increased risk for both disorders. This has allowed researchers to model the aggregate effect of genes associated with dis...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9879-z

    authors: Dezhina Z,Ranlund S,Kyriakopoulos M,Williams SCR,Dima D

    更新日期:2019-06-01 00:00:00

  • Uncinate fasciculus microstructure and verbal episodic memory in amyotrophic lateral sclerosis: a diffusion tensor imaging and neuropsychological study.

    abstract::The present study evaluates the integrity of uncinate fasciculus (UF) and the association between UF microstructure and verbal episodic memory (as one of the cognitive functions linked to UF) in non-demented patients with amyotrophic lateral sclerosis (ALS) using diffusion tensor imaging (DTI). We studied 21 patients ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-013-9271-y

    authors: Christidi F,Zalonis I,Kyriazi S,Rentzos M,Karavasilis E,Wilde EA,Evdokimidis I

    更新日期:2014-12-01 00:00:00

  • Disruption of functional connectivity among subcortical arousal system and cortical networks in temporal lobe epilepsy.

    abstract::Growing evidence has demonstrated widespread brain network alterations in temporal lobe epilepsy (TLE). However, the relatively accurate portrait of the subcortical-cortical relationship for impaired consciousness in TLE remains unclear. We proposed that consciousness-impairing seizures may invade subcortical arousal ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-0014-y

    authors: Li R,Hu C,Wang L,Liu D,Liu D,Liao W,Xiao B,Chen H,Feng L

    更新日期:2020-06-01 00:00:00

  • Diffusion tensor imaging and magnetic resonance spectroscopy in traumatic brain injury: a review of recent literature.

    abstract::Concussion is the most common form of traumatic brain injury (TBI), but diagnosis remains controversial because the brain appears quite normal in conventional computed tomography and magnetic resonance imaging (MRI). These conventional tools are not sensitive enough to detect diffuse traumatic axonal injury, and canno...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章,评审

    doi:10.1007/s11682-013-9288-2

    authors: Xiong KL,Zhu YS,Zhang WG

    更新日期:2014-12-01 00:00:00

  • A test of the role of two prefrontal/ subcortical networks in the "sequencing" of non-motor, visuo-spatial information.

    abstract::There are a number of prefrontal/sub-cortical networks in the brain (e.g., cerebellar-thalamic-prefrontal or basal ganglia/supplementary motor cortex circuits) that despite having a clear role in motor function have been shown to be involved in non-motor tasks. In this project we test for the involvement of these netw...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-011-9120-9

    authors: Tracy JI,La Q,Osipowicz K,Mamtani A,Schwartz DP,Uzelac G

    更新日期:2011-09-01 00:00:00

  • Cognitive fatigue is associated with reduced anterior internal capsule integrity in veterans with history of mild to moderate traumatic brain injury.

    abstract::No known studies have directly examined white matter microstructural correlates of cognitive fatigue post-TBI in a Veteran sample. We therefore investigated the relationship between cognitive fatigue and white matter integrity in Veterans with history of mild to moderate TBI (mmTBI). 59 Veterans (TBI = 34, Veteran Con...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-016-9594-6

    authors: Clark AL,Delano-Wood L,Sorg SF,Werhane ML,Hanson KL,Schiehser DM

    更新日期:2017-10-01 00:00:00

  • Mapping face encoding using functional MRI in multiple sclerosis across disease phenotypes.

    abstract::Using fMRI during a face encoding (FE) task, we investigated the behavioral and fMRI correlates of FE in patients with relapse-onset multiple sclerosis (MS) at different stages of the disease and their relation with attentive-executive performance and structural MRI measures of disease-related damage. A fMRI FE task w...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-016-9591-9

    authors: Rocca MA,Vacchi L,Rodegher M,Meani A,Martinelli V,Possa F,Comi G,Falini A,Filippi M

    更新日期:2017-10-01 00:00:00

  • Imaging markers of structural and functional brain changes that precede cognitive symptoms in risk for Alzheimer's disease.

    abstract::Neuroimaging has rapidly advanced investigations into dysfunction both within and emanating from the hippocampus in early Alzheimer's disease . Focusing on prodromal subjects, we will discuss structural changes to hippocampal subregions, alterations to functional activity both within the hippocampus and elsewhere in t...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章,评审

    doi:10.1007/s11682-013-9278-4

    authors: Burggren A,Brown J

    更新日期:2014-06-01 00:00:00

  • Motor and extra-motor gray matter integrity may underlie neurophysiologic parameters of motor function in amyotrophic lateral sclerosis: a combined voxel-based morphometry and transcranial stimulation study.

    abstract::The association between gray matter (GM) density and neurophysiologic changes is still unclear in amyotrophic lateral sclerosis (ALS). We evaluated the relationship between GM density and motor system integrity combining voxel-based morphometry (VBM) and transcranial magnetic stimulation (TMS) in ALS. We included 17 A...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9841-0

    authors: Christidi F,Karavasilis E,Velonakis G,Rentzos M,Zambelis T,Zouvelou V,Xirou S,Ferentinos P,Efstathopoulos E,Kelekis N,Evdokimidis I,Karandreas N

    更新日期:2018-12-01 00:00:00

  • Fusion analysis of functional MRI data for classification of individuals based on patterns of activation.

    abstract::Classification of individuals based on patterns of brain activity observed in functional MRI contrasts may be helpful for diagnosis of neurological disorders. Prior work for classification based on these patterns have primarily focused on using a single contrast, which does not take advantage of complementary informat...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-014-9292-1

    authors: Ramezani M,Abolmaesumi P,Marble K,Trang H,Johnsrude I

    更新日期:2015-06-01 00:00:00

  • Cortical sensitivity to contrast polarity and orientation of faces is modulated by temporal-nasal hemifield asymmetry.

    abstract::Behavioral studies demonstrate that the efficiency of detection of faces is dependent on configural and contrast polarity information characteristic to human faces. Stimulus inversion or contrast polarity reversal can disrupt this process. We investigated whether a face-sensitive event-related potential component, the...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-012-9147-6

    authors: Tomalski P,Johnson MH

    更新日期:2012-03-01 00:00:00

  • Supervised machine learning for diagnostic classification from large-scale neuroimaging datasets.

    abstract::There are growing concerns about the generalizability of machine learning classifiers in neuroimaging. In order to evaluate this aspect across relatively large heterogeneous populations, we investigated four disorders: Autism spectrum disorder (N = 988), Attention deficit hyperactivity disorder (N = 930), Post-traumat...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00191-8

    authors: Lanka P,Rangaprakash D,Dretsch MN,Katz JS,Denney TS Jr,Deshpande G

    更新日期:2020-12-01 00:00:00

  • Altered white matter structural networks in drug-naïve patients with obsessive-compulsive disorder.

    abstract::White matter (WM) alteration is considered to be a vital neurological mechanism of obsessive-compulsive disorder (OCD). However, little is known regarding the changes in topological organization of WM structural network in OCD. We acquired diffusion tensor imaging (DTI) datasets from 28 drug-naïve OCD patients and 28 ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-020-00278-7

    authors: Zhou C,Ping L,Chen W,He M,Xu J,Shen Z,Lu Y,Shang B,Xu X,Cheng Y

    更新日期:2020-04-20 00:00:00

  • Brain functional connectivity during storage based on resting state functional magnetic resonance imaging with synchronous urodynamic testing in healthy volunteers.

    abstract::The aim of the study was to elucidate the correlation between spatially distinct brain areas with a full bladder from the perspective of functional connectivity using resting-state functional magnetic resonance imaging (rs-fMRI) with simultaneous urodynamic testing in healthy volunteers. The brain regions with full an...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-020-00362-y

    authors: Zhao L,Liao L,Gao Y

    更新日期:2020-07-28 00:00:00

  • Brain volumes in adults with congenital heart disease correlate with executive function abilities.

    abstract::Congenital heart disease is the most common birth defect, and patients are at risk for neurodevelopmental impairment and brain abnormalities. Yet, little is known about the link between brain volumes and cognitive function in adults with congenital heart disease. Forty-four patients and 53 controls between 18 and 32 y...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-020-00424-1

    authors: Naef N,Schlosser L,Brugger P,Greutmann M,Oxenius A,Wehrle F,Kottke R,Latal B,O'Gorman RT

    更新日期:2021-01-30 00:00:00

  • Headache frequency associates with brain microstructure changes in patients with migraine without aura.

    abstract::Neuroimaging studies have implicated abnormal brain microstructure in episodic migraine (EM), but whether the pattern is altered during migraine chronification is not well known. Fifty-six patients with migraine without aura, including 39 EM patients and 17 chronic migraine (CM) patients, and 35 healthy controls (HCs)...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00232-2

    authors: Yu Y,Zhao H,Dai L,Su Y,Wang X,Chen C,Shang Y,Ke J,Hu C

    更新日期:2021-02-01 00:00:00

  • Correction to: Interactive mapping of language and memory with the GE2REC protocol.

    abstract::The article Interactive mapping of language and memory with the GE2REC protocol, written by Sonja Banjac, Elise Roger, Emilie Cousin, Marcela Perrone-Bertolotti, Célise Haldin, Cédric Pichat, Laurent Lamalle, Lorella Minotti, Philippe Kahane, and Monica Baciu was originally published electronically on the publisher's ...

    journal_title:Brain imaging and behavior

    pub_type: 已发布勘误

    doi:10.1007/s11682-020-00403-6

    authors: Banjac S,Roger E,Cousin E,Perrone-Bertolotti M,Haldin C,Pichat C,Lamalle L,Minotti L,Kahane P,Baciu M

    更新日期:2020-10-01 00:00:00

  • Imbalanced functional link between reward circuits and the cognitive control system in patients with obsessive-compulsive disorder.

    abstract::Altered reward processing and cognitive deficits are often observed in patients with obsessive-compulsive disorder (OCD); however, whether the imbalance in activity between reward circuits and the cognitive control (CC) system is associated with compulsive behavior remains unknown. Sixty-eight OCD patients and 33 cogn...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-016-9585-7

    authors: Xie C,Ma L,Jiang N,Huang R,Li L,Gong L,He C,Xiao C,Liu W,Xu S,Zhang Z

    更新日期:2017-08-01 00:00:00

  • Long-term brain effects of N-back training: an fMRI study.

    abstract::Neurobehavioral effects of cognitive training have become a popular research issue. Specifically, behavioral studies have demonstrated the long-term efficacy of cognitive training of working memory functions, but the neural basis for this training have been studied only at short-term. Using fMRI, we investigate the ce...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9925-x

    authors: Miró-Padilla A,Bueichekú E,Ventura-Campos N,Flores-Compañ MJ,Parcet MA,Ávila C

    更新日期:2019-08-01 00:00:00

  • Effects of temporarily disrupting BBB on activity-induced manganese-dependent functional MRI.

    abstract::This study further investigates the influence of temporarily disrupting the blood-brain barrier (BBB) on the level of manganese used in AIM fMRI other than the recognized function of allowing that substance to enter into the activated brain regions more effectively during the BBB opening. We injected manganese into Wi...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-011-9122-7

    authors: Fa Z,Zhang R,Li P,Zhang J,Zhang P,Zhu S,Wu Q,Huang F,Liu Y,Yang L,Chang H,Wen Z,Gao D,Zeng Y,Jiang X

    更新日期:2011-09-01 00:00:00

  • Brain structural connectomes indicate shared neural circuitry involved in subjective experience of cognitive and physical fatigue in older adults.

    abstract::Cumulative evidence suggests the existence of common processes underlying subjective experience of cognitive and physical fatigue. However, mechanistic understanding of the brain structural connections underlying the experience of fatigue in general, without the influence of clinical conditions, is limited. The purpos...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00201-9

    authors: Baran TM,Zhang Z,Anderson AJ,McDermott K,Lin F

    更新日期:2020-12-01 00:00:00

  • Neurophysiological correlates of persistent psycho-affective alterations in athletes with a history of concussion.

    abstract::Understanding the neuropathological underpinnings of sport-related concussion are critical for diagnosis, prognosis, and remediation. Although electro-encephalographic (EEG) methods have proven invaluable for understanding psycho-affective pathologies in various clinical conditions, they have not been used to understa...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-015-9473-6

    authors: Moore RD,Sauve W,Ellemberg D

    更新日期:2016-12-01 00:00:00

  • Altered structural brain connectivity involving the dorsal and ventral language pathways in 16p11.2 deletion syndrome.

    abstract::Copy number variants at the chromosomal locus 16p11.2 contribute to neurodevelopmental disorders such as autism spectrum disorders, epilepsy, schizophrenia, and language and articulation disorders. Here, we provide detailed findings on the disrupted structural brain connectivity in 16p11.2 deletion syndrome (patients:...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9859-3

    authors: Ahtam B,Link N,Hoff E,Ellen Grant P,Im K

    更新日期:2019-04-01 00:00:00

  • A multivariate pattern analysis of resting-state functional MRI data in Naïve and chronic betel quid chewers.

    abstract::Betel quid (BQ) is the fourth most commonly consumed psychoactive substance in the world. However, comprehensive functional magnetic resonance imaging (fMRI) studies exploring the neurophysiological mechanism of BQ addiction are lacking. Betel-quid-dependent (BQD) individuals (n = 24) and age-matched healthy controls ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-020-00322-6

    authors: Linli Z,Huang X,Liu Z,Guo S,Sariah A

    更新日期:2020-07-25 00:00:00

  • Claustral structural connectivity and cognitive impairment in drug naïve Parkinson's disease.

    abstract::The claustrum is a thin grey matter structure which is involved in a wide brain network. Previous studies suggested a link between claustrum and Parkinson's Disease (PD), showing how α-synuclein pathology may affect claustral neurons as well as how α-synuclein immunoreactivity may correlate with the onset of cognitive...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9907-z

    authors: Arrigo A,Calamuneri A,Milardi D,Mormina E,Gaeta M,Corallo F,Lo Buono V,Chillemi G,Marino S,Cacciola A,Di Lorenzo G,Rizzo G,Anastasi GP,Quartarone A

    更新日期:2019-08-01 00:00:00

  • Local resting state functional connectivity in autism: site and cohort variability and the effect of eye status.

    abstract::Autism spectrum disorder (ASD) is a neurodevelopmental disorder with prominent impairments in sociocommunicative abilities, which have been linked to anomalous brain network organization. Despite ample evidence of atypical long-distance connectivity, the literature on local connectivity remains small and divergent. We...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s11682-017-9678-y

    authors: Nair S,Jao Keehn RJ,Berkebile MM,Maximo JO,Witkowska N,Müller RA

    更新日期:2018-02-01 00:00:00

  • An fMRI study of age-associated changes in basic visual discrimination.

    abstract::Clinical neuropsychology lacks tests of basic visuoperceptual and spatial skills that have well-controlled administration and sophisticated measurement methods. Items from the Visual Assessment Battery (VAB), a simultaneous match-to-sample task, assessed visual discrimination in 40 healthy adults aged 51-91 during fMR...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-020-00301-x

    authors: Seider TR,Porges EC,Woods AJ,Cohen RA

    更新日期:2020-07-25 00:00:00

  • Abnormal relationships between local and global brain measures in subjects at clinical high risk for psychosis: a pilot study.

    abstract::We examined whether abnormal volumes of several brain regions as well as their mutual associations that have been observed in patients with schizophrenia, are also present in individuals at clinical high-risk (CHR) for developing psychosis. 3T magnetic resonance imaging was acquired in 19 CHR and 20 age- and handednes...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-017-9758-z

    authors: Konishi J,Del Re EC,Bouix S,Blokland GAM,Mesholam-Gately R,Woodberry K,Niznikiewicz M,Goldstein J,Hirayasu Y,Petryshen TL,Seidman LJ,Shenton ME,McCarley RW

    更新日期:2018-08-01 00:00:00

  • The reliability of individual differences in face-selective responses in the fusiform gyrus and their relation to face recognition ability.

    abstract::Face recognition ability varies widely in the normal population and there is increasing interest in linking individual differences in perception to their neural correlates. Such brain-behavior correlations require that both the behavioral measures and the selective BOLD responses be reliable. The reliability of the lo...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-015-9467-4

    authors: McGugin RW,Gauthier I

    更新日期:2016-09-01 00:00:00

  • Correction to: Age associated decline in the arcuate fasciculus and IQ.

    abstract::The author found a mistake in their published article. The sentence "The search region was limited within each side of the white matter." should read as "The search regions was limited within each side of the white matter at and above Z=0." ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s11682-019-00173-w

    authors: Ikuta T,Gollnick HM,Rutledge AN

    更新日期:2020-04-01 00:00:00