Abstract:
:Autism spectrum disorder (ASD) is a neurodevelopmental disorder with prominent impairments in sociocommunicative abilities, which have been linked to anomalous brain network organization. Despite ample evidence of atypical long-distance connectivity, the literature on local connectivity remains small and divergent. We used resting-state functional MRI regional homogeneity (ReHo) as a local connectivity measure in comparative analyses across several well-matched low-motion subsamples from the Autism Brain Imaging Data Exchange and in-house data, with a grand total of 147 ASD and 184 typically developing (TD) participants, ages 7-18 years. We tested for group differences in each subsample, with additional focus on the difference between eyes-open and eyes-closed resting states. Despite selection of highest quality data and tight demographic and motion matching between groups and across samples, few effects in exactly identical loci (voxels) were found across samples. However, there was gross consistency across all eyes-open samples of local overconnectivity (ASD > TD) in posterior, visual regions. There was also gross consistency of local underconnectivity (ASD < TD) in cingulate gyrus, although exact loci varied between mid/posterior and anterior sections. While all eyes-open datasets showed the described gross similarities, the pattern of group differences for participants scanned with eyes closed was different, with local overconnectivity in ASD in posterior cingulate gyrus, but underconnectivity in some visual regions. Our findings suggest that fMRI local connectivity measures may be relatively susceptible to site and cohort variability and that some previous inconsistencies in the ASD ReHo literature may be reconciled by more careful consideration of eye status.
journal_name
Brain Imaging Behavjournal_title
Brain imaging and behaviorauthors
Nair S,Jao Keehn RJ,Berkebile MM,Maximo JO,Witkowska N,Müller RAdoi
10.1007/s11682-017-9678-ysubject
Has Abstractpub_date
2018-02-01 00:00:00pages
168-179issue
1eissn
1931-7557issn
1931-7565pii
10.1007/s11682-017-9678-yjournal_volume
12pub_type
杂志文章,多中心研究abstract::The article Interactive mapping of language and memory with the GE2REC protocol, written by Sonja Banjac, Elise Roger, Emilie Cousin, Marcela Perrone-Bertolotti, Célise Haldin, Cédric Pichat, Laurent Lamalle, Lorella Minotti, Philippe Kahane, and Monica Baciu was originally published electronically on the publisher's ...
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journal_title:Brain imaging and behavior
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journal_title:Brain imaging and behavior
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journal_title:Brain imaging and behavior
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journal_title:Brain imaging and behavior
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journal_title:Brain imaging and behavior
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journal_title:Brain imaging and behavior
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journal_title:Brain imaging and behavior
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journal_title:Brain imaging and behavior
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pub_type: 杂志文章,已发布勘误
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journal_title:Brain imaging and behavior
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journal_title:Brain imaging and behavior
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journal_title:Brain imaging and behavior
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journal_title:Brain imaging and behavior
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journal_title:Brain imaging and behavior
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journal_title:Brain imaging and behavior
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