Abstract:
:Strong evidence is available suggesting that effective reduction of exposure to demonstrated modifiable risk factors in mid-life or before could significantly decrease the incidence of Alzheimer's disease (AD) and delay its onset. A key ingredient to achieving this goal is the reliable identification of individuals at risk well before they develop clinical symptoms. The aim of this study was to provide further neuroimaging evidence of the effectiveness of a validated tool, the ANU Alzheimer's Disease Risk Index, for the assessment of future risk of cognitive decline. Participants were 461 (60-64 years, 48% female) community-living individuals free of dementia at baseline. Associations between risk estimates obtained with the ANU-ADRI, total and regional brain volumes including in the default mode network (DMN) measured at the same assessment and diagnosis of MCI/dementia over a 12-year follow-up were tested in a large sample of community-living individuals free of dementia at baseline. Higher risk estimates on the ANU-ADRI were associated with lower cortical gray matter and particularly in the DMN. Importantly, difference in participants with high and low risk scores explained 7-9% of the observed difference in gray matter volume. In this sample, every one additional risk point on the ANU-ADRI was associated with an 8% increased risk of developing MCI/dementia over a 12-year follow-up and this association was partly mediated by a sub-region of the DMN. Risk of cognitive decline assessed with a validated instrument is associated with gray matter volume, particularly in the DMN, a region known to be implicated in the pathological process of the disease.
journal_name
Brain Imaging Behavjournal_title
Brain imaging and behaviorauthors
Cherbuin N,Shaw ME,Walsh E,Sachdev P,Anstey KJdoi
10.1007/s11682-017-9789-5subject
Has Abstractpub_date
2019-02-01 00:00:00pages
65-74issue
1eissn
1931-7557issn
1931-7565pii
10.1007/s11682-017-9789-5journal_volume
13pub_type
杂志文章abstract::Cognitive deficits, especially in the domains of social cognition and executive function including verbal fluency, are common in amyotrophic lateral sclerosis (ALS) patients. There is yet sparse understanding of pathogenesis of the underlying, possibly adaptive, cortical patterns. To address this issue, 65 patients wi...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-017-9738-3
更新日期:2018-06-01 00:00:00
abstract::In this study we longitudinally investigated the rate of microstructural alterations in the occipital cortex in different stages of Huntington's disease (HD) by applying an automated atlas-based approach to diffusion MRI data. Twenty-two premanifest (preHD), 10 early manifest HD (early HD) and 24 healthy control subje...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-018-9849-5
更新日期:2018-12-01 00:00:00
abstract::Classification of individuals based on patterns of brain activity observed in functional MRI contrasts may be helpful for diagnosis of neurological disorders. Prior work for classification based on these patterns have primarily focused on using a single contrast, which does not take advantage of complementary informat...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-014-9292-1
更新日期:2015-06-01 00:00:00
abstract::D-amphetamine (dAMPH) and methylphenidate (MPH) are stimulants used in the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Preclinical studies have shown that in healthy animals, dAMPH induces dopamine (DA) dysfunction, as evidenced for instance by loss of DA levels and its transporters. It has also been...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-014-9350-8
更新日期:2015-12-01 00:00:00
abstract::Protracted abstinence (PA) and Methadone maintenance treatment (MMT) are two main types of heroin addiction treatment, however, the effects of both measures on the functional connectivity (FC) of the brain in heroin dependents in the drug cue event-related response are unclear. Functional magnetic resonance imaging (f...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-020-00447-8
更新日期:2021-01-27 00:00:00
abstract::The steroid hormone testosterone (T) has been suggested to influence reactive aggression upon its action on the basolateral amygdala (BLA), a key brain region for threat detection. However, it is unclear whether T modulates resting-state functional connectivity (rsFC) of the BLA, and whether this predicts subsequent a...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-018-9884-2
更新日期:2019-04-01 00:00:00
abstract::The ability to suppress responses that are inappropriate, as well as the mechanisms monitoring the accuracy of actions in order to compensate for errors, is central to human behavior. Neural alterations that prevent stopping an inaccurate response, combined with a decreased ability of error monitoring, are considered ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-016-9654-y
更新日期:2017-12-01 00:00:00
abstract::To detect the abnormal cortical thickness and disrupted brain resting-state functional connectivity (RSFC) in patients with systemic lupus erythematosus (SLE) without neuropsychiatric symptoms (non-NPSLE). Using T1-weighted 3D brain structural data, we first determined the regions with abnormal cortical thickness in a...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-017-9729-4
更新日期:2018-06-01 00:00:00
abstract::Cognitive rehabilitation programs have demonstrated efficacy in improving cognitive functions in Parkinson's disease (PD), but little is known about cerebral changes associated with an integrative cognitive rehabilitation in PD. To assess structural and functional cerebral changes in PD patients, after attending a thr...
journal_title:Brain imaging and behavior
pub_type: 杂志文章,随机对照试验
doi:10.1007/s11682-016-9639-x
更新日期:2017-12-01 00:00:00
abstract::Reading disorder (RD) is characterized by deficient phonological processing, but children with RD also have cognitive control deficits, the neural correlates of which are not fully understood. We used fMRI to assess neural activity during the resolution of cognitive conflict on the Simon Spatial Incompatibility task a...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00083-x
更新日期:2020-10-01 00:00:00
abstract::A left-lateralized fronto-temporo-parietal language network has been well-characterized in adults; however, the neural basis of this fundamental network has hardly been explored in the preschool years, despite this being a time for rapid language development and vocabulary growth. We examined the functional imaging co...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-014-9342-8
更新日期:2015-03-01 00:00:00
abstract::In patients with premotor Huntington's disease (pmHD), literature has reported decreases in caudate volume. However, the regional vulnerability of the caudate nucleus to pmHD remains to be clarified. We aimed to determine whether regional structural damage of the caudate nucleus was present in pmHD and was correlated ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-016-9616-4
更新日期:2017-10-01 00:00:00
abstract::Negative urgency, defined as a tendency to act rashly under extreme negative emotion, is strongly associated with tobacco use. Despite the robust evidence linking negative urgency and tobacco use and accumulating evidence suggesting that localized, segregated brain regions such as the nucleus accumbens (NAcc), insula,...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00136-1
更新日期:2020-10-01 00:00:00
abstract::Sports-related concussion (SRC) is a complex and heterogeneous injury with psychological, cognitive and functional consequences. Advances in diffusion magnetic resonance imaging (dMRI) allow sensitive measurement of white matter pathology post-SRC and may provide insight into injury and recovery. We systematically rev...
journal_title:Brain imaging and behavior
pub_type: 杂志文章,评审
doi:10.1007/s11682-020-00336-0
更新日期:2020-07-27 00:00:00
abstract::No known studies have directly examined white matter microstructural correlates of cognitive fatigue post-TBI in a Veteran sample. We therefore investigated the relationship between cognitive fatigue and white matter integrity in Veterans with history of mild to moderate TBI (mmTBI). 59 Veterans (TBI = 34, Veteran Con...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-016-9594-6
更新日期:2017-10-01 00:00:00
abstract::Autism spectrum disorder (ASD) is a neurodevelopmental disorder with prominent impairments in sociocommunicative abilities, which have been linked to anomalous brain network organization. Despite ample evidence of atypical long-distance connectivity, the literature on local connectivity remains small and divergent. We...
journal_title:Brain imaging and behavior
pub_type: 杂志文章,多中心研究
doi:10.1007/s11682-017-9678-y
更新日期:2018-02-01 00:00:00
abstract::This study further investigates the influence of temporarily disrupting the blood-brain barrier (BBB) on the level of manganese used in AIM fMRI other than the recognized function of allowing that substance to enter into the activated brain regions more effectively during the BBB opening. We injected manganese into Wi...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-011-9122-7
更新日期:2011-09-01 00:00:00
abstract::Neuroscientific and psychological research posits that there are two transdiagnostic facets of anxiety: anxious arousal and anxious apprehension. Though these two facets of anxiety are distinct, they are often subsumed into one domain (e.g., trait anxiety). The primary goal of the current study was to delineate the re...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-017-9772-1
更新日期:2018-08-01 00:00:00
abstract::The Genetics Core of the Alzheimer's Disease Neuroimaging Initiative (ADNI), formally established in 2009, aims to provide resources and facilitate research related to genetic predictors of multidimensional Alzheimer's disease (AD)-related phenotypes. Here, we provide a systematic review of genetic studies published b...
journal_title:Brain imaging and behavior
pub_type: 杂志文章,评审
doi:10.1007/s11682-013-9262-z
更新日期:2014-06-01 00:00:00
abstract::Direct electrical stimulation mapping was used to map executive functions during awake surgery of a patient with a right frontal low-grade glioma. We specifically targeted the frontal aslant tract, as this pathway had been infiltrated by the tumor. The right frontal aslant tract has been implicated in executive functi...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-020-00439-8
更新日期:2021-01-19 00:00:00
abstract::This study examined the reliability of high angular resolution diffusion tensor imaging (HARDI) data collected on a single individual across several sessions using the same scanner. HARDI data was acquired for one healthy adult male at the same time of day on ten separate days across a one-month period. Environmental ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-015-9425-1
更新日期:2016-06-01 00:00:00
abstract::The neuroimaging literature in moral cognition has rapidly developed in the last decade with more than 200 publications on the topic. Neuroimaging based models generally agree that limbic regions work with medial prefrontal and temporal regions during moral processing to integrate emotional, social, and cognitive elem...
journal_title:Brain imaging and behavior
pub_type: 杂志文章,meta分析
doi:10.1007/s11682-019-00035-5
更新日期:2020-04-01 00:00:00
abstract::Mapping aging-related brain structure and connectivity changes can be helpful for assessing physiological brain age (PBA), which is distinct from chronological age (CA) because genetic and environmental factors affect individuals differently. This study proposes an approach whereby structural and connectomic informati...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-014-9321-0
更新日期:2015-12-01 00:00:00
abstract::Primary nocturnal enuresis (PNE) is characterized by a low cure rate and a high reoccurrence rate, since its underlying mechanism remains unclear. Based on the recent studies that thalamus plays an important role in waking up a sleeping person, here we further investigate the functional connectivity (FC) information b...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-020-00262-1
更新日期:2021-02-01 00:00:00
abstract::Assessing functional brain activation patterns in neuropsychiatric disorders such as cocaine dependence (CD) or pathological gambling (PG) under naturalistic stimuli has received rising interest in recent years. In this paper, we propose and apply a novel group-wise sparse representation framework to assess difference...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-016-9596-4
更新日期:2017-08-01 00:00:00
abstract::Pediatric bipolar disorder (PBD) is a severely debilitating illness, which is characterized by episodes of mania and depression separated by periods of remission. Little is known about the abnormalities in PBD in resting state, especially comparing manic with euthymic state. Resting state brain activity measured by fM...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00117-4
更新日期:2019-12-01 00:00:00
abstract::Neuroticism and extraversion are proposed personality dimensions for individual emotion processing. Neuroticism is correlated with depression and anxiety disorders, implicating a common neurobiological basis. Extraversion is rather inversely correlated with anxiety and depression. We examined neural correlates of pers...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-011-9114-7
更新日期:2011-06-01 00:00:00
abstract::Working memory (WM) training improves WM ability in Attention-Deficit/Hyperactivity Disorder (ADHD), but its efficacy for non-cognitive ADHD impairments ADHD has been sharply debated. The purpose of this preliminary study was to characterize WM training-related changes in ADHD brain function and see if they were linke...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-015-9416-2
更新日期:2016-06-01 00:00:00
abstract::Face recognition ability varies widely in the normal population and there is increasing interest in linking individual differences in perception to their neural correlates. Such brain-behavior correlations require that both the behavioral measures and the selective BOLD responses be reliable. The reliability of the lo...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-015-9467-4
更新日期:2016-09-01 00:00:00
abstract::Reported structural abnormalities of patients with bipolar disorder (BD) are inconsistent and the use of psychotropic medication is one of the sources of heterogeneity. A fairly small number of morphometric studies have involved comparison of BD on different mood stabilizers. Here in this study, we aimed to investigat...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-018-9950-9
更新日期:2019-10-01 00:00:00