Abstract:
:This study further investigates the influence of temporarily disrupting the blood-brain barrier (BBB) on the level of manganese used in AIM fMRI other than the recognized function of allowing that substance to enter into the activated brain regions more effectively during the BBB opening. We injected manganese into Wistar rats through ICA following the disruption of BBB with mannitol in a functional MRI test of the visual cortex. Through comparing MRI signal intensity and manganese contents in the visual cortex of rats received visual stimuli of unequal degree after the restoration of BBB, we found that the signal in the visual cortex could be further enhanced on T1WI given visual stimulation after the restoration of BBB. Temporary BBB disruption has an additional advantage in allowing Mn(2+) to enter the CSF or brain for later transference to the activated brain area. So the dosage of manganese in AIM fMRI could be minimized by extending the stimulus.
journal_name
Brain Imaging Behavjournal_title
Brain imaging and behaviorauthors
Fa Z,Zhang R,Li P,Zhang J,Zhang P,Zhu S,Wu Q,Huang F,Liu Y,Yang L,Chang H,Wen Z,Gao D,Zeng Y,Jiang Xdoi
10.1007/s11682-011-9122-7subject
Has Abstractpub_date
2011-09-01 00:00:00pages
181-8issue
3eissn
1931-7557issn
1931-7565journal_volume
5pub_type
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