Abstract:
:Neuroimaging studies have implicated abnormal brain microstructure in episodic migraine (EM), but whether the pattern is altered during migraine chronification is not well known. Fifty-six patients with migraine without aura, including 39 EM patients and 17 chronic migraine (CM) patients, and 35 healthy controls (HCs) were enrolled. Voxel-based morphometry analysis was performed to assess gray matter (GM) volume differences among groups and their association with clinical feature was examined. Compared with the HC group, both migraine groups showed increased GM volume in the periaqueductal grey matter (PAG) and decreased GM volume in the anterior cingulate cortex (ACC). The left hippocampus/parahippocampal gyrus (PHG) volume of the HC group was smaller than that of the EM group, but was larger than that of the CM group. For the dorsolateral prefrontal cortex (dlPFC), the EM group showed the smallest GM volume while the CM group had the largest volume. Higher headache frequency was associated with greater GM volume in the PAG and dlPFC, but was associated with smaller GM volume in the ACC and hippocampus/PHG across all patients. GM volume changes in regions involved in pain generation and control are potential neural mechanism underlying migraine, and are associated with migraine types and headache frequency.
journal_name
Brain Imaging Behavjournal_title
Brain imaging and behaviorauthors
Yu Y,Zhao H,Dai L,Su Y,Wang X,Chen C,Shang Y,Ke J,Hu Cdoi
10.1007/s11682-019-00232-2subject
Has Abstractpub_date
2021-02-01 00:00:00pages
60-67issue
1eissn
1931-7557issn
1931-7565pii
10.1007/s11682-019-00232-2journal_volume
15pub_type
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