Difference in regional neural fluctuations and functional connectivity in Crohn's disease: a resting-state functional MRI study.

Abstract:

:Patients with Crohn's disease (CD) are shown to have abnormal changes in brain structures. This study aimed to further investigate whether these patients have abnormal brain activities and network connectivity. Sixty patients with CD and 40 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (fMRI) scans. Amplitude of low-frequency fluctuation (ALFF) and seed-based functional connectivity (FC) were used to assess differences in spontaneous regional brain activity and functional connectivity. Compared to the HCs, patients with CD showed significantly higher ALFF values in hippocampus and parahippocampus (HIPP/paraHIPP), anterior cingulate cortex, insula, superior frontal cortex and precuneus. The ALFF values were significantly lower in secondary somatosensory cortex (S2), precentral gyrus, and medial prefrontal cortex. Functional connectivities between left HIPP and left inferior temporal cortex, and right middle cingulate cortex, HIPP, and fusiform area were significantly lower. The functional connectivities between right HIPP and right inferior orbitofrontal cortex and left HIPP were also significantly lower. Patients with CD showed higher or lower spontaneous activity in multiple brain regions. Altered activities in these brain regions may collectively reflect abnormal function and regulation of visceral pain and sensation, external environmental monitoring, and cognitive processing in these patients. Lower functional connectivity of the hippocampus-limbic system was observed in these patients. These findings may provide more information to elucidate the neurobiological mechanisms of the disease.

journal_name

Brain Imaging Behav

authors

Bao C,Liu P,Liu H,Jin X,Shi Y,Wu L,Zeng X,Zhang J,Wang D,Calhoun VD,Tian J,Wu H

doi

10.1007/s11682-018-9850-z

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

1795-1803

issue

6

eissn

1931-7557

issn

1931-7565

pii

10.1007/s11682-018-9850-z

journal_volume

12

pub_type

杂志文章
  • Alcoholism and sexual dimorphism in the middle longitudinal fascicle: a pilot study.

    abstract::Alcoholism can lead to a complex mixture of cognitive and emotional deficits associated with abnormalities in fronto-cortico-striatal-limbic brain circuitries. Given the broad variety of neurobehavioral symptoms, one would also expect alterations of postrolandic neocortical systems. Thus, we used diffusion tensor imag...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-016-9579-5

    authors: Seitz J,Sawyer KS,Papadimitriou G,Oscar-Berman M,Ng I,Kubicki A,Mouradian P,Ruiz SM,Kubicki M,Harris GJ,Makris N

    更新日期:2017-08-01 00:00:00

  • Neurobiological mechanisms associated with facial affect recognition deficits after traumatic brain injury.

    abstract::The neurobiological mechanisms that underlie facial affect recognition deficits after traumatic brain injury (TBI) have not yet been identified. Using functional magnetic resonance imaging (fMRI), study aims were to 1) determine if there are differences in brain activation during facial affect processing in people wit...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-015-9415-3

    authors: Neumann D,McDonald BC,West J,Keiski MA,Wang Y

    更新日期:2016-06-01 00:00:00

  • Parieto-frontal gyrification and working memory in healthy adults.

    abstract::Gyrification of the cortical mantle is a dynamic process that increases with cortical surface area and decreases with age. Increased gyrification is associated with higher scores on cognitive tasks in adults; however, the degree to which this relationship is independent of cortical surface area remains undefined. This...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-017-9696-9

    authors: Green S,Blackmon K,Thesen T,DuBois J,Wang X,Halgren E,Devinsky O

    更新日期:2018-04-01 00:00:00

  • Occipital cortical gyrification reductions associate with decreased functional connectivity in amyotrophic lateral sclerosis.

    abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive muscular weakness and atrophy. Several morphometric studies have been conducted to investigate the gray matter volume or thickness changes in ALS, whereas the cortical folding pattern remains poorly understood. In the...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-015-9499-9

    authors: Zhang Y,Fang T,Wang Y,Guo X,Alarefi A,Wang J,Jiang T,Zhang J

    更新日期:2017-02-01 00:00:00

  • A prospective microstructure imaging study in mixed-martial artists using geometric measures and diffusion tensor imaging: methods and findings.

    abstract::Although diffusion magnetic resonance imaging (dMRI) has been widely used to characterize the effects of repetitive mild traumatic brain injury (rmTBI), to date no studies have investigated how novel geometric models of microstructure relate to more typical diffusion tensor imaging (DTI) sequences. Moreover, few studi...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-016-9546-1

    authors: Mayer AR,Ling JM,Dodd AB,Meier TB,Hanlon FM,Klimaj SD

    更新日期:2017-06-01 00:00:00

  • Changes in dynamic resting state network connectivity following aphasia therapy.

    abstract::Resting state magnetic resonance imaging (rsfMRI) permits observation of intrinsic neural networks produced by task-independent correlations in low frequency brain activity. Various resting state networks have been described, with each thought to reflect common engagement in some shared function. There has been limite...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-017-9771-2

    authors: Duncan ES,Small SL

    更新日期:2018-08-01 00:00:00

  • Cortical signatures of cognition and their relationship to Alzheimer's disease.

    abstract::Recent changes in diagnostic criteria for Alzheimer's disease (AD) state that biomarkers can enhance certainty in a diagnosis of AD. In the present study, we combined cognitive function and brain morphology, a potential imaging biomarker, to predict conversion from mild cognitive impairment to AD. We identified four b...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-012-9180-5

    authors: Gross AL,Manly JJ,Pa J,Johnson JK,Park LQ,Mitchell MB,Melrose RJ,Inouye SK,McLaren DG,Alzheimer’s Disease Neuroimaging Initiative.

    更新日期:2012-12-01 00:00:00

  • Comparison of ApoE-related brain connectivity differences in early MCI and normal aging populations: an fMRI study.

    abstract::In this study, we used resting-state functional magnetic resonance imaging (rs-fMRI) scans from subjects with early mild cognitive impairment (EMCI) and control subjects to study functional network connectivity. The scans were acquired by the Alzheimer's Disease Neuroimaging Initiative (ADNI). We used genetic data fro...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-015-9451-z

    authors: McKenna F,Koo BB,Killiany R,Alzheimer’s Disease Neuroimaging Initiative.

    更新日期:2016-12-01 00:00:00

  • Common and distinct global functional connectivity density alterations in patients with bipolar disorder with and without auditory verbal hallucination during major depressive episodes.

    abstract::Although an increasing number of studies has explored the neural mechanisms of auditory verbal hallucination (AVH) using many modalities, including neuroimaging, neurotransmitters, and electroencephalography, the etiology of AVH remains unclear. In this study, we investigated the neuroimaging characteristics of AVH in...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00222-4

    authors: Qiu L,Ye J,Ji F,Li G,Li G,Ma X,Li R,Tian H,Wang L,Chen G,Xu Y,Wang W,Jiang D,Pan J,Zhuo C

    更新日期:2020-12-01 00:00:00

  • A preliminary report of cerebral white matter microstructural changes associated with adolescent sports concussion acutely and subacutely using diffusion tensor imaging.

    abstract::Diffusion tensor imaging (DTI) has demonstrated its utility in detecting microscopic post-concussion cerebral white matter structural changes, which are not routinely evident on conventional neuroimaging modalities. In this study, we compared 10 adolescents with sports concussion (SC) to 12 orthopedically-injured (OI)...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-017-9752-5

    authors: Wu T,Merkley TL,Wilde EA,Barnes A,Li X,Chu ZD,McCauley SR,Hunter JV,Levin HS

    更新日期:2018-08-01 00:00:00

  • Neurophysiological correlates of persistent psycho-affective alterations in athletes with a history of concussion.

    abstract::Understanding the neuropathological underpinnings of sport-related concussion are critical for diagnosis, prognosis, and remediation. Although electro-encephalographic (EEG) methods have proven invaluable for understanding psycho-affective pathologies in various clinical conditions, they have not been used to understa...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-015-9473-6

    authors: Moore RD,Sauve W,Ellemberg D

    更新日期:2016-12-01 00:00:00

  • Acute social stress modulates coherence regional homogeneity.

    abstract::It is a generally accepted observation that individuals act differently under stress. Recent task-based neuroimaging studies have shown that individuals under stress favor the intuitive and fast system over the deliberative and reflective system. In the present study, using a within-subjects design in thirty young adu...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9898-9

    authors: Chang J,Yu R

    更新日期:2019-06-01 00:00:00

  • Neural correlates of personality dimensions and affective measures during the anticipation of emotional stimuli.

    abstract::Neuroticism and extraversion are proposed personality dimensions for individual emotion processing. Neuroticism is correlated with depression and anxiety disorders, implicating a common neurobiological basis. Extraversion is rather inversely correlated with anxiety and depression. We examined neural correlates of pers...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-011-9114-7

    authors: Brühl AB,Viebke MC,Baumgartner T,Kaffenberger T,Herwig U

    更新日期:2011-06-01 00:00:00

  • Altered segregation between task-positive and task-negative regions in mild traumatic brain injury.

    abstract::Changes in large-scale brain networks that accompany mild traumatic brain injury (mTBI) were investigated using functional magnetic resonance imaging (fMRI) during the N-back working memory task at two cognitive loads (1-back and 2-back). Thirty mTBI patients were examined during the chronic stage of injury and compar...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-017-9724-9

    authors: Sours C,Kinnison J,Padmala S,Gullapalli RP,Pessoa L

    更新日期:2018-06-01 00:00:00

  • Neural correlates of correct and failed response inhibition in heavy versus light social drinkers: an fMRI study during a go/no-go task by healthy participants.

    abstract::The ability to suppress responses that are inappropriate, as well as the mechanisms monitoring the accuracy of actions in order to compensate for errors, is central to human behavior. Neural alterations that prevent stopping an inaccurate response, combined with a decreased ability of error monitoring, are considered ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-016-9654-y

    authors: Campanella S,Absil J,Carbia Sinde C,Schroder E,Peigneux P,Bourguignon M,Petieau M,Metens T,Nouali M,Goldman S,Cheron G,Verbanck P,De Tiège X

    更新日期:2017-12-01 00:00:00

  • Metabolic imaging of mild traumatic brain injury.

    abstract::Traumatic brain injury results in a metabolic cascade of changes that occur at the molecular level, invisible to conventional imaging methods such as computed tomography or magnetic resonance imaging. Non-invasive metabolic imaging tools such as single photon emission computed tomography (SPECT), positron emission tom...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章,评审

    doi:10.1007/s11682-012-9181-4

    authors: Lin AP,Liao HJ,Merugumala SK,Prabhu SP,Meehan WP 3rd,Ross BD

    更新日期:2012-06-01 00:00:00

  • Trait and state patterns of basolateral amygdala connectivity at rest are related to endogenous testosterone and aggression in healthy young women.

    abstract::The steroid hormone testosterone (T) has been suggested to influence reactive aggression upon its action on the basolateral amygdala (BLA), a key brain region for threat detection. However, it is unclear whether T modulates resting-state functional connectivity (rsFC) of the BLA, and whether this predicts subsequent a...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9884-2

    authors: Buades-Rotger M,Engelke C,Krämer UM

    更新日期:2019-04-01 00:00:00

  • Modeling motor task activation from resting-state fMRI using machine learning in individual subjects.

    abstract::Resting-state functional MRI (rs-fMRI) has provided important insights into brain physiology. It has become an increasingly popular method for presurgical mapping, as an alternative to task-based functional MRI wherein the subject performs a task while being scanned. However, there is no commonly acknowledged gold sta...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00239-9

    authors: Niu C,Cohen AD,Wen X,Chen Z,Lin P,Liu X,Menze BH,Wiestler B,Wang Y,Zhang M

    更新日期:2021-02-01 00:00:00

  • Neural mechanisms of risky decision making in adolescents reporting frequent alcohol and/or marijuana use.

    abstract::Because adolescence is a period of heightened exploration of new behaviors, there is a natural increase in risk taking including initial use of alcohol and marijuana. In order to better understand potential differences in neurocognitive functioning among adolescents who use drugs, the current study aimed to identify t...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-017-9723-x

    authors: Claus ED,Feldstein Ewing SW,Magnan RE,Montanaro E,Hutchison KE,Bryan AD

    更新日期:2018-04-01 00:00:00

  • Plasma lipids are associated with white matter microstructural changes and axonal degeneration.

    abstract::Dislipidemia is a risk factor for cognitive impairment. We studied the association between interindividual variability of plasma lipids and white matter (WM) microstructure, using diffusion tensor imaging (DTI) in 273 healthy adults. Special focus was placed on 7 regions of interest (ROI) which are structural componen...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-020-00311-9

    authors: Iriondo A,García-Sebastian M,Arrospide A,Arriba M,Aurtenetxe S,Barandiaran M,Clerigue M,Ecay-Torres M,Estanga A,Gabilondo A,Izagirre A,Saldias J,Tainta M,Villanua J,Mar J,Goñi FM,Martínez-Lage P

    更新日期:2020-08-03 00:00:00

  • Altered gray matter volume in primary insomnia patients: a DARTEL-VBM study.

    abstract::Previous neuroimaging studies have reported brain morphological alterations and the occurrence of mental disorders in primary insomnia (PI) patients. However, studies of the effect of disrupted sleep on brain structure have showed inconsistent results. In this study, DARTEL-VBM was used to evaluate the changes in gray...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9844-x

    authors: Li M,Yan J,Li S,Wang T,Wen H,Yin Y,Fu S,Zeng L,Tian J,Jiang G

    更新日期:2018-12-01 00:00:00

  • The relationship between microvasculature in white matter hyperintensities and cognitive function.

    abstract::White matter hyperintensities (WMHs) are associated with cognitive decline, but less is known about pathophysiology of cognitive decline in patients with WMHs. We investigated microvasculature and microstructure in WMHs using intravoxel incoherent motion (IVIM) and their associations with cognitive function. Thirty-tw...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-016-9531-8

    authors: Sun J,Yu X,Jiaerken Y,Song R,Huang P,Wang C,Yuan L,Mao Y,Guo Y,Yu H,Zhang M

    更新日期:2017-04-01 00:00:00

  • Functional reorganization during cognitive function tasks in patients with amyotrophic lateral sclerosis.

    abstract::Cognitive deficits, especially in the domains of social cognition and executive function including verbal fluency, are common in amyotrophic lateral sclerosis (ALS) patients. There is yet sparse understanding of pathogenesis of the underlying, possibly adaptive, cortical patterns. To address this issue, 65 patients wi...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-017-9738-3

    authors: Keller J,Böhm S,Aho-Özhan HEA,Loose M,Gorges M,Kassubek J,Uttner I,Abrahams S,Ludolph AC,Lulé D

    更新日期:2018-06-01 00:00:00

  • Brain structural connectomes indicate shared neural circuitry involved in subjective experience of cognitive and physical fatigue in older adults.

    abstract::Cumulative evidence suggests the existence of common processes underlying subjective experience of cognitive and physical fatigue. However, mechanistic understanding of the brain structural connections underlying the experience of fatigue in general, without the influence of clinical conditions, is limited. The purpos...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00201-9

    authors: Baran TM,Zhang Z,Anderson AJ,McDermott K,Lin F

    更新日期:2020-12-01 00:00:00

  • Relationship of negative urgency to cingulo-insular and cortico-striatal resting state functional connectivity in tobacco use.

    abstract::Negative urgency, defined as a tendency to act rashly under extreme negative emotion, is strongly associated with tobacco use. Despite the robust evidence linking negative urgency and tobacco use and accumulating evidence suggesting that localized, segregated brain regions such as the nucleus accumbens (NAcc), insula,...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-019-00136-1

    authors: Um M,Hummer TA,Cyders MA

    更新日期:2020-10-01 00:00:00

  • Spatial distribution bias in subject-specific abnormalities analyses.

    abstract::The neuroimaging community has seen a renewed interest in algorithms that provide a location-independent summary of subject-specific abnormalities (SSA) to assess individual lesion load. More recently, these methods have been extended to assess whether multiple individuals within the same cohort exhibit extrema in the...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9836-x

    authors: Dodd AB,Ling JM,Bedrick EJ,Meier TB,Mayer AR

    更新日期:2018-12-01 00:00:00

  • Structural and functional neural correlates of self-reported attachment in healthy adults: evidence for an amygdalar involvement.

    abstract::The concept of attachment in long-term interpersonal relationships has been linked to relationship outcome and social-emotional health. To date, no relationship between the structural properties of the human amygdala and attachment in romantic relationships (measured through self-reported attachment related anxiety an...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-015-9446-9

    authors: Rigon A,Duff MC,Voss MW

    更新日期:2016-12-01 00:00:00

  • Altered white matter structural networks in drug-naïve patients with obsessive-compulsive disorder.

    abstract::White matter (WM) alteration is considered to be a vital neurological mechanism of obsessive-compulsive disorder (OCD). However, little is known regarding the changes in topological organization of WM structural network in OCD. We acquired diffusion tensor imaging (DTI) datasets from 28 drug-naïve OCD patients and 28 ...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-020-00278-7

    authors: Zhou C,Ping L,Chen W,He M,Xu J,Shen Z,Lu Y,Shang B,Xu X,Cheng Y

    更新日期:2020-04-20 00:00:00

  • Effects of levodopa therapy on voxel-based degree centrality in Parkinson's disease.

    abstract::Levodopa therapy is widely recognized as an effective treatment for PD patients, however, it is rare of the study looking at effects of levodopa therapy on the whole-brain network. This study was to evaluate the effects of levodopa on whole-brain degree centrality (DC) and seed-based functional connectivity (FC) in PD...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-018-9936-7

    authors: Zhong M,Yang W,Huang B,Jiang W,Zhang X,Liu X,Wang L,Wang J,Zhao L,Zhang Y,Liu Y,Lin J,Huang R

    更新日期:2019-10-01 00:00:00

  • Functional connectivity of thalamus in children with primary nocturnal enuresis: results from a resting-state fMRI study.

    abstract::Primary nocturnal enuresis (PNE) is characterized by a low cure rate and a high reoccurrence rate, since its underlying mechanism remains unclear. Based on the recent studies that thalamus plays an important role in waking up a sleeping person, here we further investigate the functional connectivity (FC) information b...

    journal_title:Brain imaging and behavior

    pub_type: 杂志文章

    doi:10.1007/s11682-020-00262-1

    authors: Zhang A,Zhang L,Wang M,Zhang Y,Jiang F,Jin X,Du X,Ma J

    更新日期:2021-02-01 00:00:00