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Altered segregation between task-positive and task-negative regions in mild traumatic brain injury.

Abstract：

:Changes in large-scale brain networks that accompany mild traumatic brain injury (mTBI) were investigated using functional magnetic resonance imaging (fMRI) during the N-back working memory task at two cognitive loads (1-back and 2-back). Thirty mTBI patients were examined during the chronic stage of injury and compared to 28 control participants. Demographics and behavioral performance were matched across groups. Due to the diffuse nature of injury, we hypothesized that there would be an imbalance in the communication between task-positive and Default Mode Network (DMN) regions in the context of effortful task execution. Specifically, a graph-theoretic measure of modularity was used to quantify the extent to which groups of brain regions tended to segregate into task-positive and DMN sub-networks. Relative to controls, mTBI patients showed reduced segregation between the DMN and task-positive networks, but increased functional connectivity within the DMN regions during the more cognitively demanding 2-back task. Together, our findings reveal that patients exhibit alterations in the communication between and within neural networks during a cognitively demanding task. These findings reveal altered processes that persist through the chronic stage of injury, highlighting the need for longitudinal research to map the neural recovery of mTBI patients.

journal_name

Brain Imaging Behav

journal_title

Brain imaging and behavior

authors

Sours C,Kinnison J,Padmala S,Gullapalli RP,Pessoa L

doi

10.1007/s11682-017-9724-9

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

697-709

issue

3

eissn

1931-7557

issn

1931-7565

pii

10.1007/s11682-017-9724-9

journal_volume

12

pub_type

杂志文章

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