Abstract:
:Dislipidemia is a risk factor for cognitive impairment. We studied the association between interindividual variability of plasma lipids and white matter (WM) microstructure, using diffusion tensor imaging (DTI) in 273 healthy adults. Special focus was placed on 7 regions of interest (ROI) which are structural components of cognitive neurocircuitry. We also investigated the effect of plasma lipids on cerebrospinal fluid (CSF) neurofilament light chain (NfL), an axonal degeneration marker. Low density lipoprotein (LDL) and triglyceride (TG) levels showed a negative association with axial diffusivity (AxD) in multiple regions. High density lipoproteins (HDL) showed a positive correlation. The association was independent of Apolipoprotein E (APOE) genotype, blood pressure or use of statins. LDL moderated the relation between NfL and AxD in the body of the corpus callosum (p = 0.041), right cingulum gyrus (p = 0.041), right fornix/stria terminalis (p = 0.025) and right superior longitudinal fasciculus (p = 0.020) and TG in the right inferior longitudinal fasciculus (p = 0.004) and left fornix/stria terminalis (p = 0.001). We conclude that plasma lipids are associated to WM microstructural changes and axonal degeneration and might represent a risk factor in the transition from healthy aging to disease.
journal_name
Brain Imaging Behavjournal_title
Brain imaging and behaviorauthors
Iriondo A,García-Sebastian M,Arrospide A,Arriba M,Aurtenetxe S,Barandiaran M,Clerigue M,Ecay-Torres M,Estanga A,Gabilondo A,Izagirre A,Saldias J,Tainta M,Villanua J,Mar J,Goñi FM,Martínez-Lage Pdoi
10.1007/s11682-020-00311-9subject
Has Abstractpub_date
2020-08-03 00:00:00eissn
1931-7557issn
1931-7565pii
10.1007/s11682-020-00311-9pub_type
杂志文章abstract::Brain development during childhood and early adolescence is characterized by global changes in brain architecture. Neuroimaging studies have revealed overall decreases in cortical thickness (CT) and increases in fractional anisotropy (FA). Furthermore, previous studies have shown that certain cortical regions display ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-016-9555-0
更新日期:2017-06-01 00:00:00
abstract::Levodopa therapy is widely recognized as an effective treatment for PD patients, however, it is rare of the study looking at effects of levodopa therapy on the whole-brain network. This study was to evaluate the effects of levodopa on whole-brain degree centrality (DC) and seed-based functional connectivity (FC) in PD...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-018-9936-7
更新日期:2019-10-01 00:00:00
abstract::The article Interactive mapping of language and memory with the GE2REC protocol, written by Sonja Banjac, Elise Roger, Emilie Cousin, Marcela Perrone-Bertolotti, Célise Haldin, Cédric Pichat, Laurent Lamalle, Lorella Minotti, Philippe Kahane, and Monica Baciu was originally published electronically on the publisher's ...
journal_title:Brain imaging and behavior
pub_type: 已发布勘误
doi:10.1007/s11682-020-00403-6
更新日期:2020-10-01 00:00:00
abstract::Socioeconomic status (SES) during childhood is a well-documented life-course health determinant. Despite recent advances on characterizing brain structural variance associated with SES during development, how it influences brain's functional organization remains elusive. Associations between SES, an fMRI feature of re...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00073-z
更新日期:2020-08-01 00:00:00
abstract::To assess the feasibility of a cognitive rehabilitation program in breast cancer survivors (BCS) with persistent post-treatment cognitive complaints. BCS with cognitive complaints, 18-months to 5-years post-treatment, were recruited for a once-weekly, five-week, group cognitive training intervention. Outcome measures ...
journal_title:Brain imaging and behavior
pub_type: 临床试验,杂志文章
doi:10.1007/s11682-013-9237-0
更新日期:2013-12-01 00:00:00
abstract::Excessive intake of high-caloric diets as well as subsequent development of obesity and diabetes mellitus may exert a wide range of unfavorable effects on the central nervous system (CNS) in the long-term. The potentially harmful effects of such diets were suggested to be mitigated by physical exercise. Here, we condu...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-016-9638-y
更新日期:2017-10-01 00:00:00
abstract::Prenatal alcohol exposure leads to alterations in cognition, behavior and underlying brain architecture. However, prior studies have not integrated structural and functional imaging data in children with prenatal alcohol exposure. The aim of this study was to characterize disruptions in both structural and functional ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-020-00277-8
更新日期:2020-04-18 00:00:00
abstract::White matter hyperintensities (WMHs) are associated with cognitive decline, but less is known about pathophysiology of cognitive decline in patients with WMHs. We investigated microvasculature and microstructure in WMHs using intravoxel incoherent motion (IVIM) and their associations with cognitive function. Thirty-tw...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-016-9531-8
更新日期:2017-04-01 00:00:00
abstract::It is a generally accepted observation that individuals act differently under stress. Recent task-based neuroimaging studies have shown that individuals under stress favor the intuitive and fast system over the deliberative and reflective system. In the present study, using a within-subjects design in thirty young adu...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-018-9898-9
更新日期:2019-06-01 00:00:00
abstract::Performance in verbal fluency tasks are widely used as a marker of cognitive impairment in Parkinson disease. However, the anatomical substrate of its impairment remains undetermined. Based on the dual-stream language model, we hypothesized cortical input to the subcortical circuitry would be a crucial determinant of ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-020-00407-2
更新日期:2020-10-12 00:00:00
abstract:BACKGROUND:Abnormal neural activities during emotional processing have been found in both adults and youths with major depressive disorder. However, findings were inconsistent in each group and cannot be compared to each other. METHODS:We first identified neuroimaging experiments that revealed abnormal neural activiti...
journal_title:Brain imaging and behavior
pub_type: 杂志文章,评审
doi:10.1007/s11682-020-00299-2
更新日期:2020-07-24 00:00:00
abstract::Using fMRI during a face encoding (FE) task, we investigated the behavioral and fMRI correlates of FE in patients with relapse-onset multiple sclerosis (MS) at different stages of the disease and their relation with attentive-executive performance and structural MRI measures of disease-related damage. A fMRI FE task w...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-016-9591-9
更新日期:2017-10-01 00:00:00
abstract::The COMT Val158Met polymorphism has recently been identified as a predictor for cognitive decline in Parkinson's disease (PD). However, it remains unknown whether an early brain structural compromise could be involved in this clinical association. Here, in a cohort of 120 cognitively preserved de novo PD patients from...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-018-0022-y
更新日期:2020-04-01 00:00:00
abstract::Sports-related concussion (SRC) is a complex and heterogeneous injury with psychological, cognitive and functional consequences. Advances in diffusion magnetic resonance imaging (dMRI) allow sensitive measurement of white matter pathology post-SRC and may provide insight into injury and recovery. We systematically rev...
journal_title:Brain imaging and behavior
pub_type: 杂志文章,评审
doi:10.1007/s11682-020-00336-0
更新日期:2020-07-27 00:00:00
abstract::To detect the abnormal cortical thickness and disrupted brain resting-state functional connectivity (RSFC) in patients with systemic lupus erythematosus (SLE) without neuropsychiatric symptoms (non-NPSLE). Using T1-weighted 3D brain structural data, we first determined the regions with abnormal cortical thickness in a...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-017-9729-4
更新日期:2018-06-01 00:00:00
abstract::Neuroimaging studies have implicated abnormal brain microstructure in episodic migraine (EM), but whether the pattern is altered during migraine chronification is not well known. Fifty-six patients with migraine without aura, including 39 EM patients and 17 chronic migraine (CM) patients, and 35 healthy controls (HCs)...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00232-2
更新日期:2021-02-01 00:00:00
abstract::With disease progression, patients with Parkinson's disease (PD) may have chronic visual hallucinations (VH). The mechanisms behind this invalidating non-motor symptom remain largely unknown, namely because it is extremely difficult to capture hallucination events. This study aimed to describe the patterns of brain fu...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00185-6
更新日期:2020-04-01 00:00:00
abstract::We sought to characterize electrophysiological, eye-tracking and behavioral correlates of face-name recognition memory in healthy younger adults using high-density electroencephalography (EEG), infrared eye-tracking (ET), and neuropsychological measures. Twenty-one participants first studied 40 face-name (FN) pairs; 2...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-015-9420-6
更新日期:2016-06-01 00:00:00
abstract::A suggestive hypothesis proposed that the lateral prefrontal cortex (LPFC) may be identified as the site of emotion-memory integration, since it was shown to be sensitive to the encoding and retrieval of emotional content. In the present research we explored the role of the dorsolateral prefrontal cortex (DLPFC) in me...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-012-9163-6
更新日期:2012-09-01 00:00:00
abstract::White matter (WM) alteration is considered to be a vital neurological mechanism of obsessive-compulsive disorder (OCD). However, little is known regarding the changes in topological organization of WM structural network in OCD. We acquired diffusion tensor imaging (DTI) datasets from 28 drug-naïve OCD patients and 28 ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-020-00278-7
更新日期:2020-04-20 00:00:00
abstract::Recent evidence from neurophysiological and functional imaging research has demonstrated that semantically congruent sounds can modulate the identification of a degraded visual object. However, it remains unclear how different integration regions interact with each other when only a visual object was obscured. The pre...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00134-3
更新日期:2020-08-01 00:00:00
abstract::Dopamine D2 receptors mediate the rewarding effects of many drugs of abuse. In humans, several polymorphisms in DRD2, the gene encoding these receptors, increase our genetic risk for developing addictive disorders. Here, we examined one of the most frequently studied candidate variant for addiction in DRD2 for associa...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-014-9298-8
更新日期:2015-06-01 00:00:00
abstract::Resting-state functional MRI (rs-fMRI) has provided important insights into brain physiology. It has become an increasingly popular method for presurgical mapping, as an alternative to task-based functional MRI wherein the subject performs a task while being scanned. However, there is no commonly acknowledged gold sta...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00239-9
更新日期:2021-02-01 00:00:00
abstract::Abnormalities in brain white matter (WM) structure have been reported in youths having a family history of substance use disorders (SUDs). It was hypothesized that these abnormalities constitute features of the liability for SUDs transmitted across generations. The association between severity of intergenerational ris...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-017-9679-x
更新日期:2018-02-01 00:00:00
abstract::Negative urgency, defined as a tendency to act rashly under extreme negative emotion, is strongly associated with tobacco use. Despite the robust evidence linking negative urgency and tobacco use and accumulating evidence suggesting that localized, segregated brain regions such as the nucleus accumbens (NAcc), insula,...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00136-1
更新日期:2020-10-01 00:00:00
abstract::Assessing functional brain activation patterns in neuropsychiatric disorders such as cocaine dependence (CD) or pathological gambling (PG) under naturalistic stimuli has received rising interest in recent years. In this paper, we propose and apply a novel group-wise sparse representation framework to assess difference...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-016-9596-4
更新日期:2017-08-01 00:00:00
abstract::This study tested the hypothesis that frequent participation in cognitively-stimulating activities, specifically those related to playing games and puzzles, is beneficial to brain health and cognition among middle-aged adults at increased risk for Alzheimer's disease (AD). Three hundred twenty-nine cognitively normal,...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-014-9329-5
更新日期:2015-12-01 00:00:00
abstract::Betel quid (BQ) is the fourth most commonly consumed psychoactive substance in the world. However, comprehensive functional magnetic resonance imaging (fMRI) studies exploring the neurophysiological mechanism of BQ addiction are lacking. Betel-quid-dependent (BQD) individuals (n = 24) and age-matched healthy controls ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-020-00322-6
更新日期:2020-07-25 00:00:00
abstract::Copy number variants at the chromosomal locus 16p11.2 contribute to neurodevelopmental disorders such as autism spectrum disorders, epilepsy, schizophrenia, and language and articulation disorders. Here, we provide detailed findings on the disrupted structural brain connectivity in 16p11.2 deletion syndrome (patients:...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-018-9859-3
更新日期:2019-04-01 00:00:00
abstract::The author found a mistake in their published article. The sentence "The search region was limited within each side of the white matter." should read as "The search regions was limited within each side of the white matter at and above Z=0." ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章,已发布勘误
doi:10.1007/s11682-019-00173-w
更新日期:2020-04-01 00:00:00