Abstract:
:Genetic variation in the kidney and brain expressed protein (KIBRA) rs17070145 gene has been linked to episodic memory and cognitive aging; yet, the neural mechanism underlying this association remains to be fully understood. Using the magnetic resonance imaging (MRI) technique, this study investigated the effect of KIBRA polymorphism on gray matter volume in 37 healthy, Chinese adults from the older population. Voxel-based morphometry (VBM) analysis revealed that KIBRA gene selectivity influences the prefrontal cortex and the parahippocampal cortex. The gray matter volume (GMV) in these structures is significantly lower in KIBRA C-allele carriers than in TT carriers. Moreover, multi-voxel pattern correlation analysis revealed that decreased prefrontal GMV could in turn affect individual cognitive function in C-allele carriers; whereas, TT individuals utilized more integrated gray matter volume in whole-brain voxels to achieve relatively better cognitive function. Overall, the findings suggest that the KIBRA rs17070145 polymorphism modulates gray matter volume, which in turn further influences cognitive function in the elderly.
journal_name
Brain Imaging Behavjournal_title
Brain imaging and behaviorauthors
Li R,Wan W,Li Jdoi
10.1007/s11682-019-00047-1subject
Has Abstractpub_date
2020-10-01 00:00:00pages
1388-1394issue
5eissn
1931-7557issn
1931-7565pii
10.1007/s11682-019-00047-1journal_volume
14pub_type
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