Abstract：
:Seventeen subjects underwent functional magnetic resonance imaging (fMRI) performing a 2-Back verbal working memory (VWM) task alternating with a control task to characterize the temporal dynamics of the specific brain regions involved in VWM. Serial sampling of 2-Back sub-blocks revealed many small areas of activation that grew and merged over time. Significant temporal effects for volume recruitment were seen in specific brain regions known to be involved in VWM, including the bilateral dorsolateral prefrontal (DLPFC), medial frontal (MFC), posterior parietal (PPC) cortices and also some extra-cortical and subcortical regions of interest (ROIs). Signal intensity increased over time in most ROIs recruited early in the task, including the DLPFC, MFC, and PPC but excluding dorsal premotor areas. MFC intensity increased rapidly then stabilized with time. The uniqueness of the MFC response raises the possibility that it drives the recruitment process. Increases in intensity and volume were associated with worsening VWM performance over time, suggesting that recruitment of brain resources is necessary in attempting to sustain difficult tasks. Worsening of performance over sub-blocks despite stable task demands reinforces this temporal "load effect".
journal_name
Brain Imaging Behavjournal_title
Brain imaging and behaviorauthors
Paskavitz JF,Sweet LH,Wellen J,Helmer KG,Rao SM,Cohen RAdoi
10.1007/s11682-009-9081-4subject
Has Abstractpub_date
2010-03-01 00:00:00pages
5-21issue
1eissn
1931-7557issn
1931-7565journal_volume
4pub_type
杂志文章abstract：:The current report used structural magnetic resonance imaging (MRI) to objectively measure olfactory bulb volume and olfactory sulcal depth in patients diagnosed with chronic schizophrenia and healthy controls. Additional measures were obtained to assess olfactory function. The olfactory bulb and sulcus were manually ...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-011-9129-0
更新日期：2011-12-01 00:00:00
abstract：:Performance in verbal fluency tasks are widely used as a marker of cognitive impairment in Parkinson disease. However, the anatomical substrate of its impairment remains undetermined. Based on the dual-stream language model, we hypothesized cortical input to the subcortical circuitry would be a crucial determinant of ...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-020-00407-2
更新日期：2020-10-12 00:00:00
abstract：:Machine learning methods have been widely used for early diagnosis of Alzheimer's disease (AD) via functional connectivity networks (FCNs) analysis from neuroimaging data. The conventional low-order FCNs are obtained by time-series correlation of the whole brain based on resting-state functional magnetic resonance ima...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-019-00255-9
更新日期：2021-02-01 00:00:00
abstract：:Patients with Crohn's disease (CD) are shown to have abnormal changes in brain structures. This study aimed to further investigate whether these patients have abnormal brain activities and network connectivity. Sixty patients with CD and 40 healthy controls (HCs) underwent resting-state functional magnetic resonance i...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-018-9850-z
更新日期：2018-12-01 00:00:00
abstract：:Primary lateral sclerosis (PLS) is classically considered a 'pure' upper motor neuron disorder. Motor cortex atrophy and pyramidal tract degeneration are thought to be pathognomonic of PLS, but extra-motor cerebral changes are poorly characterized. In a prospective neuroimaging study, forty PLS patients were systemati...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-020-00421-4
更新日期：2021-01-07 00:00:00
abstract：:Working memory (WM) training improves WM ability in Attention-Deficit/Hyperactivity Disorder (ADHD), but its efficacy for non-cognitive ADHD impairments ADHD has been sharply debated. The purpose of this preliminary study was to characterize WM training-related changes in ADHD brain function and see if they were linke...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-015-9416-2
更新日期：2016-06-01 00:00:00
abstract：:The neuroimaging community has seen a renewed interest in algorithms that provide a location-independent summary of subject-specific abnormalities (SSA) to assess individual lesion load. More recently, these methods have been extended to assess whether multiple individuals within the same cohort exhibit extrema in the...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-018-9836-x
更新日期：2018-12-01 00:00:00
abstract：:Previous meta-analyses found abnormal brain activations in schizophrenia patients compared with normal controls when performing working memory tasks. Although most studies focused on dysfunction of the working memory activation network in schizophrenia patients, deactivation abnormalities of the working memory in the ...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-019-00071-1
更新日期：2020-08-01 00:00:00
abstract：:We sought to characterize electrophysiological, eye-tracking and behavioral correlates of face-name recognition memory in healthy younger adults using high-density electroencephalography (EEG), infrared eye-tracking (ET), and neuropsychological measures. Twenty-one participants first studied 40 face-name (FN) pairs; 2...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-015-9420-6
更新日期：2016-06-01 00:00:00
abstract：:The ability to recognize others' emotions is critical to successful interpersonal interactions. Given its importance, there has been an extensive amount of research using functional magnetic resonance imaging (fMRI) to investigate the neurobiological mechanisms associated with facial affect recognition in healthy indi...
journal_title：Brain imaging and behavior
pub_type： 杂志文章,评审
doi：10.1007/s11682-013-9285-5
更新日期：2014-09-01 00:00:00
abstract：:Joint analysis of genetic and neuroimaging data, known as Imaging Genetics (IG), offers an opportunity to deepen our knowledge of the biological mechanisms of neurodevelopmental domains. There has been exponential growth in the literature on IG studies, which challenges the standardization of analysis methods in this ...
journal_title：Brain imaging and behavior
pub_type： 杂志文章,评审
doi：10.1007/s11682-016-9663-x
更新日期：2017-12-01 00:00:00
abstract：:In this study, we used resting-state functional magnetic resonance imaging (rs-fMRI) scans from subjects with early mild cognitive impairment (EMCI) and control subjects to study functional network connectivity. The scans were acquired by the Alzheimer's Disease Neuroimaging Initiative (ADNI). We used genetic data fro...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-015-9451-z
更新日期：2016-12-01 00:00:00
abstract：:Neuroimaging has rapidly advanced investigations into dysfunction both within and emanating from the hippocampus in early Alzheimer's disease . Focusing on prodromal subjects, we will discuss structural changes to hippocampal subregions, alterations to functional activity both within the hippocampus and elsewhere in t...
journal_title：Brain imaging and behavior
pub_type： 杂志文章,评审
doi：10.1007/s11682-013-9278-4
更新日期：2014-06-01 00:00:00
abstract：:Traumatic events can produce emotional, cognitive and autonomous physical responses. This may ultimately lead to post-traumatic stress disorder (PTSD), a psychiatric syndrome which requires comprehensive treatment. Trauma exposure alters functional connectivity; however, onset and nature of these changes are unknown. ...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-020-00396-2
更新日期：2020-09-28 00:00:00
abstract：:Several models have been proposed to account for observed overlaps in clinical features and genetic predisposition between schizophrenia and autism spectrum disorder. This study assessed similarities and differences in topological patterns and vectors of glucose metabolism in both disorders in reference to these model...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-017-9721-z
更新日期：2018-04-01 00:00:00
abstract：:Neuroticism and extraversion are proposed personality dimensions for individual emotion processing. Neuroticism is correlated with depression and anxiety disorders, implicating a common neurobiological basis. Extraversion is rather inversely correlated with anxiety and depression. We examined neural correlates of pers...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-011-9114-7
更新日期：2011-06-01 00:00:00
abstract：:Growing evidence has demonstrated widespread brain network alterations in temporal lobe epilepsy (TLE). However, the relatively accurate portrait of the subcortical-cortical relationship for impaired consciousness in TLE remains unclear. We proposed that consciousness-impairing seizures may invade subcortical arousal ...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-018-0014-y
更新日期：2020-06-01 00:00:00
abstract：:Diffusion tensor imaging (DTI) has demonstrated its utility in detecting microscopic post-concussion cerebral white matter structural changes, which are not routinely evident on conventional neuroimaging modalities. In this study, we compared 10 adolescents with sports concussion (SC) to 12 orthopedically-injured (OI)...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-017-9752-5
更新日期：2018-08-01 00:00:00
abstract：:Copy number variants at the chromosomal locus 16p11.2 contribute to neurodevelopmental disorders such as autism spectrum disorders, epilepsy, schizophrenia, and language and articulation disorders. Here, we provide detailed findings on the disrupted structural brain connectivity in 16p11.2 deletion syndrome (patients:...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-018-9859-3
更新日期：2019-04-01 00:00:00
abstract：:Face recognition ability varies widely in the normal population and there is increasing interest in linking individual differences in perception to their neural correlates. Such brain-behavior correlations require that both the behavioral measures and the selective BOLD responses be reliable. The reliability of the lo...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-015-9467-4
更新日期：2016-09-01 00:00:00
abstract：:Cognitive rehabilitation programs have demonstrated efficacy in improving cognitive functions in Parkinson's disease (PD), but little is known about cerebral changes associated with an integrative cognitive rehabilitation in PD. To assess structural and functional cerebral changes in PD patients, after attending a thr...
journal_title：Brain imaging and behavior
pub_type： 杂志文章,随机对照试验
doi：10.1007/s11682-016-9639-x
更新日期：2017-12-01 00:00:00
abstract：:This study examined the reliability of high angular resolution diffusion tensor imaging (HARDI) data collected on a single individual across several sessions using the same scanner. HARDI data was acquired for one healthy adult male at the same time of day on ten separate days across a one-month period. Environmental ...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-015-9425-1
更新日期：2016-06-01 00:00:00
abstract：:The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium brings together researchers from around the world to try to identify the genetic underpinnings of brain structure and function, along with robust, generalizable effects of neurological and psychiatric disorders. The recently-formed ENIGMA Br...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-021-00450-7
更新日期：2021-01-27 00:00:00
abstract：:The neuroimaging literature in moral cognition has rapidly developed in the last decade with more than 200 publications on the topic. Neuroimaging based models generally agree that limbic regions work with medial prefrontal and temporal regions during moral processing to integrate emotional, social, and cognitive elem...
journal_title：Brain imaging and behavior
pub_type： 杂志文章,meta分析
doi：10.1007/s11682-019-00035-5
更新日期：2020-04-01 00:00:00
abstract：:White matter alterations related to hypocretin pathway have been less evaluated in patients who have narcolepsy with cataplexy (NC), as compared to the identified exploration of gray matter and have varied among structural brain magnetic resonance imaging studies. The aim of this study was to investigate the disruptio...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-019-00100-z
更新日期：2020-10-01 00:00:00
abstract：:It is a generally accepted observation that individuals act differently under stress. Recent task-based neuroimaging studies have shown that individuals under stress favor the intuitive and fast system over the deliberative and reflective system. In the present study, using a within-subjects design in thirty young adu...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-018-9898-9
更新日期：2019-06-01 00:00:00
abstract：:Clinical neuropsychology lacks tests of basic visuoperceptual and spatial skills that have well-controlled administration and sophisticated measurement methods. Items from the Visual Assessment Battery (VAB), a simultaneous match-to-sample task, assessed visual discrimination in 40 healthy adults aged 51-91 during fMR...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-020-00301-x
更新日期：2020-07-25 00:00:00
abstract：:Deficits in communication are a core feature of autism spectrum disorder (ASD), however, structural language abilities are highly variable, ranging from minimally verbal to superior linguistic skills. Differences in the anatomy of cortical language regions, including anterior and posterior areas, have been found in AS...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-017-9795-7
更新日期：2018-10-01 00:00:00
abstract：:Because adolescence is a period of heightened exploration of new behaviors, there is a natural increase in risk taking including initial use of alcohol and marijuana. In order to better understand potential differences in neurocognitive functioning among adolescents who use drugs, the current study aimed to identify t...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-017-9723-x
更新日期：2018-04-01 00:00:00
abstract：:Reported structural abnormalities of patients with bipolar disorder (BD) are inconsistent and the use of psychotropic medication is one of the sources of heterogeneity. A fairly small number of morphometric studies have involved comparison of BD on different mood stabilizers. Here in this study, we aimed to investigat...
journal_title：Brain imaging and behavior
pub_type： 杂志文章
doi：10.1007/s11682-018-9950-9
更新日期：2019-10-01 00:00:00
