Abstract:
:Several models have been proposed to account for observed overlaps in clinical features and genetic predisposition between schizophrenia and autism spectrum disorder. This study assessed similarities and differences in topological patterns and vectors of glucose metabolism in both disorders in reference to these models. Co-registered 18fluorodeoxyglucose PET and MRI scans were obtained in 41 schizophrenia, 25 ASD, and 55 healthy control subjects. AFNI was used to map cortical and subcortical regions of interest. Metabolic rates were compared between three diagnostic groups using univariate and multivariate repeated-measures ANOVA. Compared to controls, metabolic rates in schizophrenia subjects were decreased in the frontal lobe, anterior cingulate, superior temporal gyrus, amygdala and medial thalamic nuclei; rates were increased in the occipital cortex, hippocampus, basal ganglia and lateral thalamic nuclei. In ASD subjects metabolic rates were decreased in the parietal lobe, frontal premotor and eye-fields areas, and amygdala; rates were increased in the posterior cingulate, occipital cortex, hippocampus and basal ganglia. In relation to controls, subjects with ASD and schizophrenia showed opposite changes in metabolic rates in the primary motor and somatosensory cortex, anterior cingulate and hypothalamus; similar changes were found in prefrontal and occipital cortices, inferior parietal lobule, amygdala, hippocampus, and basal ganglia. Schizophrenia and ASD appear to be associated with a similar pattern of metabolic abnormalities in the social brain. Divergent maladaptive trade-offs, as postulated by the diametrical hypothesis of their evolutionary relationship, may involve a more circumscribed set of anterior cingulate, motor and somatosensory regions and the specific cognitive functions they subserve.
journal_name
Brain Imaging Behavjournal_title
Brain imaging and behaviorauthors
Mitelman SA,Bralet MC,Mehmet Haznedar M,Hollander E,Shihabuddin L,Hazlett EA,Buchsbaum MSdoi
10.1007/s11682-017-9721-zsubject
Has Abstractpub_date
2018-04-01 00:00:00pages
532-546issue
2eissn
1931-7557issn
1931-7565pii
10.1007/s11682-017-9721-zjournal_volume
12pub_type
杂志文章abstract::Traumatic brain injury results in a metabolic cascade of changes that occur at the molecular level, invisible to conventional imaging methods such as computed tomography or magnetic resonance imaging. Non-invasive metabolic imaging tools such as single photon emission computed tomography (SPECT), positron emission tom...
journal_title:Brain imaging and behavior
pub_type: 杂志文章,评审
doi:10.1007/s11682-012-9181-4
更新日期:2012-06-01 00:00:00
abstract::We sought to characterize electrophysiological, eye-tracking and behavioral correlates of face-name recognition memory in healthy younger adults using high-density electroencephalography (EEG), infrared eye-tracking (ET), and neuropsychological measures. Twenty-one participants first studied 40 face-name (FN) pairs; 2...
journal_title:Brain imaging and behavior
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journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-016-9531-8
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abstract::This study further investigates the influence of temporarily disrupting the blood-brain barrier (BBB) on the level of manganese used in AIM fMRI other than the recognized function of allowing that substance to enter into the activated brain regions more effectively during the BBB opening. We injected manganese into Wi...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-011-9122-7
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abstract::To assess the feasibility of a cognitive rehabilitation program in breast cancer survivors (BCS) with persistent post-treatment cognitive complaints. BCS with cognitive complaints, 18-months to 5-years post-treatment, were recruited for a once-weekly, five-week, group cognitive training intervention. Outcome measures ...
journal_title:Brain imaging and behavior
pub_type: 临床试验,杂志文章
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journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-020-00274-x
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journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00073-z
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journal_title:Brain imaging and behavior
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更新日期:2015-12-01 00:00:00
abstract::Assessing functional brain activation patterns in neuropsychiatric disorders such as cocaine dependence (CD) or pathological gambling (PG) under naturalistic stimuli has received rising interest in recent years. In this paper, we propose and apply a novel group-wise sparse representation framework to assess difference...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-016-9596-4
更新日期:2017-08-01 00:00:00
abstract::Relative to the general population, criminal offenders have a higher risk of suicide. Neurobiological deficits related to suicidal behavior have been identified in the general population, but unexamined in offenders to date. We examined the association between brain morphology and suicidal behavior in adult male crimi...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-018-9957-2
更新日期:2020-02-01 00:00:00
abstract::How and when the known genetic risk allele, apolipoprotein E-epsilon4 (APOEepsilon4), confers risk to Alzheimer's disease has yet to be determined. We studied older adults and found that APOEepsilon4 carriers had greater neural activation in the medial frontal and parahippocampal gyrus during a memory task (cluster-co...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-010-9097-9
更新日期:2010-06-01 00:00:00
abstract::Nicotine addiction is characterized as a neural circuit dysfunction, particularly with regard to the alterations in central reward pathways. The insula, a cortical region that is thought to play a central role in this reward circuitry, has been implicated in the maintenance of nicotine addiction. However, it remains l...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-020-00389-1
更新日期:2020-09-24 00:00:00
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journal_title:Brain imaging and behavior
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doi:10.1007/s11682-015-9473-6
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journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-017-9679-x
更新日期:2018-02-01 00:00:00
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journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-014-9298-8
更新日期:2015-06-01 00:00:00
abstract::White matter (WM) alteration is considered to be a vital neurological mechanism of obsessive-compulsive disorder (OCD). However, little is known regarding the changes in topological organization of WM structural network in OCD. We acquired diffusion tensor imaging (DTI) datasets from 28 drug-naïve OCD patients and 28 ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-020-00278-7
更新日期:2020-04-20 00:00:00
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doi:10.1007/s11682-020-00439-8
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journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00097-5
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pub_type: 杂志文章,评审
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abstract::Neuroscientific and psychological research posits that there are two transdiagnostic facets of anxiety: anxious arousal and anxious apprehension. Though these two facets of anxiety are distinct, they are often subsumed into one domain (e.g., trait anxiety). The primary goal of the current study was to delineate the re...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-017-9772-1
更新日期:2018-08-01 00:00:00
abstract::Dementia with Lewy bodies (DLB) is often associated with occipital hypometabolism or hypoperfusion, as well as deficits in cholinergic neurotransmission. In this study, 11 mild DLB, 16 mild AD and 16 age-matched controls underwent arterial spin-labeled perfusion MRI (ASL-pMRI) and neuropsychological testing. Patterns ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-010-9108-x
更新日期:2011-03-01 00:00:00
abstract::Diffusion tensor imaging (DTI) has demonstrated its utility in detecting microscopic post-concussion cerebral white matter structural changes, which are not routinely evident on conventional neuroimaging modalities. In this study, we compared 10 adolescents with sports concussion (SC) to 12 orthopedically-injured (OI)...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-017-9752-5
更新日期:2018-08-01 00:00:00
abstract::Performance in verbal fluency tasks are widely used as a marker of cognitive impairment in Parkinson disease. However, the anatomical substrate of its impairment remains undetermined. Based on the dual-stream language model, we hypothesized cortical input to the subcortical circuitry would be a crucial determinant of ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-020-00407-2
更新日期:2020-10-12 00:00:00
abstract::Primary nocturnal enuresis (PNE) is characterized by a low cure rate and a high reoccurrence rate, since its underlying mechanism remains unclear. Based on the recent studies that thalamus plays an important role in waking up a sleeping person, here we further investigate the functional connectivity (FC) information b...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-020-00262-1
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journal_title:Brain imaging and behavior
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doi:10.1007/s11682-017-9738-3
更新日期:2018-06-01 00:00:00
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journal_title:Brain imaging and behavior
pub_type: 杂志文章
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更新日期:2011-12-01 00:00:00
abstract::Adolescence represents an ideal time for elucidating the etiology of cue reactivity profiles. This study examined the influence of three risk factors consistently associated with heavy adolescent drinking on alcohol cue reactivity. Youth were first assessed while still naïve to alcohol (12-14 years old) and followed a...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
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