Abstract:
:White matter alterations related to hypocretin pathway have been less evaluated in patients who have narcolepsy with cataplexy (NC), as compared to the identified exploration of gray matter and have varied among structural brain magnetic resonance imaging studies. The aim of this study was to investigate the disruption of specific white matter tracts in drug-naïve patients with NC, by using a tract-specific statistical analysis (TSSA). Forty drug-naïve NC patients with cataplexy and 42 heathy controls were enrolled in the study. All participants completed diffusion weighted imaging, polysomnography, and neuropsychological testing. At that time, we automatically identified fourteen major fiber tracts using diffusion tensor imaging techniques and analyzed the group comparison of fractional anisotropy (FA) values for each tract between the NC and controls, controlling for the participant's age and gender. The mean age of the NC patients was 26.9 years and the onset age of daytime sleepiness and cataplexy was 16.7 years and 19.9 years, respectively. Relative to the controls, the NC patients showed that there were identified decreased FA values in the bilateral inferior fronto-occipital fasciculus (IFO). The Epworth sleepiness scale was positively correlated with FA values for the left IFO and right cingulate. The REM sleep latency was positively correlated with FA values for the left IFO, cingulate, and uncinate fasciculus in patients. This TSSA study revealed disintegration of the IFO in the NC patients and suggested that disintegration of WM tracts connected to the frontal cortex contributes to clinical manifestations of narcolepsy.
journal_name
Brain Imaging Behavjournal_title
Brain imaging and behaviorauthors
Park HR,Kim HR,Seong JK,Joo EYdoi
10.1007/s11682-019-00100-zsubject
Has Abstractpub_date
2020-10-01 00:00:00pages
1674-1681issue
5eissn
1931-7557issn
1931-7565pii
10.1007/s11682-019-00100-zjournal_volume
14pub_type
杂志文章abstract::Previous neuroimaging studies have reported brain morphological alterations and the occurrence of mental disorders in primary insomnia (PI) patients. However, studies of the effect of disrupted sleep on brain structure have showed inconsistent results. In this study, DARTEL-VBM was used to evaluate the changes in gray...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-018-9844-x
更新日期:2018-12-01 00:00:00
abstract::Socioeconomic status (SES) during childhood is a well-documented life-course health determinant. Despite recent advances on characterizing brain structural variance associated with SES during development, how it influences brain's functional organization remains elusive. Associations between SES, an fMRI feature of re...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00073-z
更新日期:2020-08-01 00:00:00
abstract::Because adolescence is a period of heightened exploration of new behaviors, there is a natural increase in risk taking including initial use of alcohol and marijuana. In order to better understand potential differences in neurocognitive functioning among adolescents who use drugs, the current study aimed to identify t...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-017-9723-x
更新日期:2018-04-01 00:00:00
abstract::Alcoholism can lead to a complex mixture of cognitive and emotional deficits associated with abnormalities in fronto-cortico-striatal-limbic brain circuitries. Given the broad variety of neurobehavioral symptoms, one would also expect alterations of postrolandic neocortical systems. Thus, we used diffusion tensor imag...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-016-9579-5
更新日期:2017-08-01 00:00:00
abstract::Neuroimaging has rapidly advanced investigations into dysfunction both within and emanating from the hippocampus in early Alzheimer's disease . Focusing on prodromal subjects, we will discuss structural changes to hippocampal subregions, alterations to functional activity both within the hippocampus and elsewhere in t...
journal_title:Brain imaging and behavior
pub_type: 杂志文章,评审
doi:10.1007/s11682-013-9278-4
更新日期:2014-06-01 00:00:00
abstract::Feeling of presence (FOP) refers to the vivid sensation of a person's presence near oneself and is common in Dementia with Lewy Bodies (DLB). Based on previous observations on epileptic subjects, we hypothesized that DLB subjects with FOP would harbour 18F-fluorodeoxyglucose PET hypometabolism in left parietal areas. ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-018-9997-7
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Abnormal neural activities during emotional processing have been found in both adults and youths with major depressive disorder. However, findings were inconsistent in each group and cannot be compared to each other. METHODS:We first identified neuroimaging experiments that revealed abnormal neural activiti...
journal_title:Brain imaging and behavior
pub_type: 杂志文章,评审
doi:10.1007/s11682-020-00299-2
更新日期:2020-07-24 00:00:00
abstract::This study investigated the brain areas involved in episodic memory retrieval of pictures depending on the characteristics of the contextual environment during encoding (i.e. presence or absence of an odor). In the first stage, subjects were presented with a series of 32 pictures. Half of the pictures were presented w...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-012-9218-8
更新日期:2013-06-01 00:00:00
abstract::The present study evaluates the integrity of uncinate fasciculus (UF) and the association between UF microstructure and verbal episodic memory (as one of the cognitive functions linked to UF) in non-demented patients with amyotrophic lateral sclerosis (ALS) using diffusion tensor imaging (DTI). We studied 21 patients ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-013-9271-y
更新日期:2014-12-01 00:00:00
abstract::Neuroimaging studies have implicated abnormal brain microstructure in episodic migraine (EM), but whether the pattern is altered during migraine chronification is not well known. Fifty-six patients with migraine without aura, including 39 EM patients and 17 chronic migraine (CM) patients, and 35 healthy controls (HCs)...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00232-2
更新日期:2021-02-01 00:00:00
abstract::There are growing concerns about the generalizability of machine learning classifiers in neuroimaging. In order to evaluate this aspect across relatively large heterogeneous populations, we investigated four disorders: Autism spectrum disorder (N = 988), Attention deficit hyperactivity disorder (N = 930), Post-traumat...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00191-8
更新日期:2020-12-01 00:00:00
abstract::Congenital heart disease is the most common birth defect, and patients are at risk for neurodevelopmental impairment and brain abnormalities. Yet, little is known about the link between brain volumes and cognitive function in adults with congenital heart disease. Forty-four patients and 53 controls between 18 and 32 y...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-020-00424-1
更新日期:2021-01-30 00:00:00
abstract::Chronic Traumatic Encephalopathy (CTE) is a neurodegenerative disease thought to be caused, at least in part, by repetitive brain trauma, including concussive and subconcussive injuries. It is thought to result in executive dysfunction, memory impairment, depression and suicidality, apathy, poor impulse control, and e...
journal_title:Brain imaging and behavior
pub_type: 杂志文章,评审
doi:10.1007/s11682-012-9164-5
更新日期:2012-06-01 00:00:00
abstract::Neuroscientific and psychological research posits that there are two transdiagnostic facets of anxiety: anxious arousal and anxious apprehension. Though these two facets of anxiety are distinct, they are often subsumed into one domain (e.g., trait anxiety). The primary goal of the current study was to delineate the re...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-017-9772-1
更新日期:2018-08-01 00:00:00
abstract::Despite the many studies documenting cerebral white matter microstructural alterations associated with very preterm birth (<32 weeks' gestation), there is a dearth of similar research in moderate and late preterm infants (born 32-36 weeks' gestation), who experience higher rates of neurodevelopmental delays than infan...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-015-9361-0
更新日期:2016-03-01 00:00:00
abstract::Posttraumatic stress disorder (PTSD) is characterized by intrusions, avoidance, and hyperarousal while patients of the dissociative subtype (PTSD-D) experience additional dissociative symptoms. A neurobiological model proposes hyper-inhibition of limbic structures mediated by prefrontal cortices to underlie dissociati...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-020-00274-x
更新日期:2020-04-27 00:00:00
abstract::This study tested the hypothesis that frequent participation in cognitively-stimulating activities, specifically those related to playing games and puzzles, is beneficial to brain health and cognition among middle-aged adults at increased risk for Alzheimer's disease (AD). Three hundred twenty-nine cognitively normal,...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-014-9329-5
更新日期:2015-12-01 00:00:00
abstract::Restless legs syndrome (RLS) is common in the end-stage renal disease (ESRD) population; however, their interrelationship remains largely unclear. In the current study, we aimed to investigate the brain structure variation in ESRD patients with RLS (ERSD-RLS) and its potential relation with the severity of RLS. Diffus...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-018-9968-z
更新日期:2020-02-01 00:00:00
abstract::White matter hyperintensities (WMH) are commonly detected in the brain of elderly individuals and have been associated with a negative impact on multiple cognitive domains. We aim to investigate the impact of global and regional distribution of WMH on episodic memory and executive function in middle-aged cognitively u...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00151-2
更新日期:2020-10-01 00:00:00
abstract::To detect the abnormal cortical thickness and disrupted brain resting-state functional connectivity (RSFC) in patients with systemic lupus erythematosus (SLE) without neuropsychiatric symptoms (non-NPSLE). Using T1-weighted 3D brain structural data, we first determined the regions with abnormal cortical thickness in a...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-017-9729-4
更新日期:2018-06-01 00:00:00
abstract::This study further investigates the influence of temporarily disrupting the blood-brain barrier (BBB) on the level of manganese used in AIM fMRI other than the recognized function of allowing that substance to enter into the activated brain regions more effectively during the BBB opening. We injected manganese into Wi...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-011-9122-7
更新日期:2011-09-01 00:00:00
abstract::Machine learning methods have been widely used for early diagnosis of Alzheimer's disease (AD) via functional connectivity networks (FCNs) analysis from neuroimaging data. The conventional low-order FCNs are obtained by time-series correlation of the whole brain based on resting-state functional magnetic resonance ima...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00255-9
更新日期:2021-02-01 00:00:00
abstract::Using fMRI during a face encoding (FE) task, we investigated the behavioral and fMRI correlates of FE in patients with relapse-onset multiple sclerosis (MS) at different stages of the disease and their relation with attentive-executive performance and structural MRI measures of disease-related damage. A fMRI FE task w...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-016-9591-9
更新日期:2017-10-01 00:00:00
abstract::Parkinson's disease (PD) is associated with abnormal synchronization in basal ganglia-thalamo-cortical loops. We tested whether early PD patients without demonstrable cognitive impairment exhibit abnormal modulation of functional connectivity at rest, while engaged in a task, or both. PD and healthy controls underwent...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-014-9317-9
更新日期:2015-09-01 00:00:00
abstract::To assess the feasibility of a cognitive rehabilitation program in breast cancer survivors (BCS) with persistent post-treatment cognitive complaints. BCS with cognitive complaints, 18-months to 5-years post-treatment, were recruited for a once-weekly, five-week, group cognitive training intervention. Outcome measures ...
journal_title:Brain imaging and behavior
pub_type: 临床试验,杂志文章
doi:10.1007/s11682-013-9237-0
更新日期:2013-12-01 00:00:00
abstract::Joint analysis of genetic and neuroimaging data, known as Imaging Genetics (IG), offers an opportunity to deepen our knowledge of the biological mechanisms of neurodevelopmental domains. There has been exponential growth in the literature on IG studies, which challenges the standardization of analysis methods in this ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章,评审
doi:10.1007/s11682-016-9663-x
更新日期:2017-12-01 00:00:00
abstract::Growing evidence has demonstrated widespread brain network alterations in temporal lobe epilepsy (TLE). However, the relatively accurate portrait of the subcortical-cortical relationship for impaired consciousness in TLE remains unclear. We proposed that consciousness-impairing seizures may invade subcortical arousal ...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-018-0014-y
更新日期:2020-06-01 00:00:00
abstract::Primary nocturnal enuresis (PNE) is characterized by a low cure rate and a high reoccurrence rate, since its underlying mechanism remains unclear. Based on the recent studies that thalamus plays an important role in waking up a sleeping person, here we further investigate the functional connectivity (FC) information b...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-020-00262-1
更新日期:2021-02-01 00:00:00
abstract::Reported structural abnormalities of patients with bipolar disorder (BD) are inconsistent and the use of psychotropic medication is one of the sources of heterogeneity. A fairly small number of morphometric studies have involved comparison of BD on different mood stabilizers. Here in this study, we aimed to investigat...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-018-9950-9
更新日期:2019-10-01 00:00:00
abstract::Cumulative evidence suggests the existence of common processes underlying subjective experience of cognitive and physical fatigue. However, mechanistic understanding of the brain structural connections underlying the experience of fatigue in general, without the influence of clinical conditions, is limited. The purpos...
journal_title:Brain imaging and behavior
pub_type: 杂志文章
doi:10.1007/s11682-019-00201-9
更新日期:2020-12-01 00:00:00