Abstract:
:Feeling of presence (FOP) refers to the vivid sensation of a person's presence near oneself and is common in Dementia with Lewy Bodies (DLB). Based on previous observations on epileptic subjects, we hypothesized that DLB subjects with FOP would harbour 18F-fluorodeoxyglucose PET hypometabolism in left parietal areas. 25 subjects (mean age 71.9 ± 6.7, disease duration at scan 1.7 ± 1.5 years) were included in the study, of whom nine (36%) experienced FOP. No significant between-group difference was observed regarding dopamine transporters striatal uptake (p = 0.64), daily dopaminergic treatment dosage (p = 0.88) and visual hallucinations (p = 0.83). Statistical parametric mapping showed that subjects with FOP had a significantly reduced glucose metabolism in several left frontoparietal areas (p < 0.001), including superior parietal lobule and precuneus. Interregional correlation analysis of these areas showed specific connectivity with right insula and putamen in the FOP subgroup and right orbitofrontal and superior frontal in subjects without FOP. This provides further evidence about the role of a left frontoparietal network and suggest a possible contribution of impaired orbitofrontal reality filtering associated with FOP.
journal_name
Brain Imaging Behavjournal_title
Brain imaging and behaviorauthors
Nicastro N,Eger AF,Assal F,Garibotto Vdoi
10.1007/s11682-018-9997-7subject
Has Abstractpub_date
2020-08-01 00:00:00pages
1199-1207issue
4eissn
1931-7557issn
1931-7565pii
10.1007/s11682-018-9997-7journal_volume
14pub_type
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journal_title:Brain imaging and behavior
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