Abstract:
:A computational approach which concomitantly determines the capacity-limited rate constants of parent drug elimination and metabolite formation is presented. The approach applies both the presently derived total excretory recovery versus dose relationships of the metabolite and the AUC versus dose relationships of the parent drug to identify the parameters. Three parent drug elimination conditions were assessed: pooled first-order, pooled Michaelis-Menten, and parallel first-order and pooled Michaelis-Menten kinetics. Model and parameter identification criteria are discussed. Literature data for theophylline and two of its metabolites in rats were examined to reveal pooled Michaelis-Menten elimination kinetics of theophylline and capacity-limited formation of the metabolites. The proposed technique is useful for quantitating commonly obtained nonlinear drug disposition data such as AUC and amount of metabolites excreted.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Chow AT,Jusko WJdoi
10.1002/jps.2600791012subject
Has Abstractpub_date
1990-10-01 00:00:00pages
902-6issue
10eissn
0022-3549issn
1520-6017pii
S0022-3549(15)48358-3journal_volume
79pub_type
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