Abstract：
:Budd-Chiari syndrome (BCS) is a rare liver disease characterised by the obstruction of draining hepatic veins, and subsequent reduced blood return to the heart. Although many clinical BCS studies have been reported, few studies have quantified the associated changes that occur in the entire hepatic circulation. In this communication, we present an electrical analog model of the hepatic circulation that incorporates the Hepatic Arterial Buffer Response (HABR) mechanism in both the left and right lobes. Using this model we can simulate the hepatic flow under both normal and acute BCS conditions. The model can capture subtle features in the hepatic circulation, such as reduced total portal flow but increased arterial flow under BCS. This observation was previously reported in literature and may have clinical implications. As such, we suggest the presented model could be used for the analysis of systematic haemodynamic changes of BCS and therefore may be useful in supporting clinical interventions.
journal_name
Med Eng Physjournal_title
Medical engineering & physicsauthors
Ho H,Qiu Cdoi
10.1016/j.medengphy.2019.04.010subject
Has Abstractpub_date
2019-07-01 00:00:00pages
134-139eissn
1350-4533issn
1873-4030pii
S1350-4533(19)30078-5journal_volume
69pub_type
杂志文章abstract：:Sequentially drilling multiple holes in bone is used clinically for surface preparation to aid in fusion of a joint, typically under non-irrigated conditions. Drilling induces a significant amount of heat and accumulates after multiple passes, which can result in thermal osteonecrosis and various complications. To und...
journal_title：Medical engineering & physics
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journal_title：Medical engineering & physics
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