Abstract:
:Miniaturized and parallelized sandwich immunoassays allow the simultaneous analysis of a variety of parameters in a single experiment. Bead-based protein array systems or suspension microarrays are well-established multiplex sandwich immunoassay formats. To study inflammatory diseases, protein arrays can be used to analyze changes in plasma protein levels, such as cytokines, chemokines, soluble receptors, and matrix metalloproteinases. Using the bead-based Luminex system, multiplexed sandwich immunoassays have been developed to analyze the plasma concentrations of soluble receptors: sTNF-RI, sTNF-RII, sIL-2R, sgp130, sFas, sRAGE, sE-selectin, sICAM-1, sVCAM-1, sMIF-1 and sFasL. This newly established 11-plex soluble receptors assay demonstrated acceptable intra-assay and inter-assay precision, appropriate accuracy, and no crossreactivity between analytes. Using this assay, 100 plasma samples derived from 36 critically ill intensive care unit (ICU) patients with trauma or sepsis were analyzed for their soluble receptor plasma concentrations. Results obtained allowed grouping of patients' samples into a trauma and a sepsis group. Four candidate molecules: sFas, sICAM-1, sTNF-RI, and sTNF-RII had higher concentrations in patients with sepsis than in those with trauma, contributing the highest discriminatory values to define the nature of the inflammatory disease originating from pathogen-involved (sepsis) or pathogen-independent inflammation.
journal_name
Med Eng Physjournal_title
Medical engineering & physicsauthors
Hsu HY,Wittemann S,Schneider EM,Weiss M,Joos TOdoi
10.1016/j.medengphy.2008.01.003subject
Has Abstractpub_date
2008-10-01 00:00:00pages
976-83issue
8eissn
1350-4533issn
1873-4030pii
S1350-4533(08)00020-9journal_volume
30pub_type
杂志文章abstract::Acetabular fractures potentially account for up to half of all pelvic fractures, while pelvic fractures potentially account for over one-tenth of all human bone fractures. This is the first biomechanical study to assess acetabular fracture fixation using plates versus cables in the presence of a total hip arthroplasty...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/j.medengphy.2017.06.004
更新日期:2017-08-01 00:00:00
abstract::The current strategy for the control of tuberculosis (TB) relies on early diagnosis, and smear microscopy is an essential component of the laboratory diagnosis of TB in most countries with a high prevalence of the disease. However, even simple smear microscopy examination is far from satisfactory because staining resu...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/s1350-4533(02)00213-8
更新日期:2003-05-01 00:00:00
abstract::Single-photon emission computed tomography (SPECT) of dopamine transporters with (99m)Tc-TRODAT-1 has recently been proposed to offer valuable information for the diagnosis of Parkinson's disease (PD). Furthermore, High-intensity focused ultrasound (HIFU) is a newly developed technique in which the energy of ultrasoun...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/j.medengphy.2012.01.006
更新日期:2013-02-01 00:00:00
abstract::Fetal movement is one index of fetal well-being. We designed and built a new recorder based on fetal movement acceleration measurement (FMAM). The FMAM recorder has a newly developed, capacitive acceleration sensor that can detect the oscillations of the maternal abdominal wall caused by fetal movements. In this study...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/j.medengphy.2011.09.001
更新日期:2012-06-01 00:00:00
abstract::Artificial blood pumps play an increasingly important role in the treatment of end-stage cardiac failure. The fluid dynamics of blood flow through such devices crucially affects their clinical effectiveness. Specifically, if the flow of blood stagnates or slowly re-circulates thrombus formation can occur and the avoid...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/s1350-4533(00)00023-0
更新日期:2000-04-01 00:00:00
abstract::This study proposes semi-automatic determination of geometrical features in hip magnetic resonance (MR) images in order to evaluate the Legg-Calvé-Perthes disease (LCPD). Nine anatomical points on a hip image are selected by a clinician; then eight geometrical indexes of the hip joint are calculated: acetabulum head i...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/j.medengphy.2004.10.003
更新日期:2005-06-01 00:00:00
abstract::The diagnosis of aseptic loosening of hip implants is often challenging. A vibrational analysis of the bone-implant interface could be an alternative method to analyze the fixation of endoprostheses. We assessed an innovative and new approach for excitation by using extracorporeal shockwaves in this study. In three ca...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/j.medengphy.2014.11.011
更新日期:2015-02-01 00:00:00
abstract::We present a finite element based simulation and analysis method to describe the spatial extent of stimulation and the effects of electrode-tissue interactions in subretinal prostheses. In particular, we estimate the threshold stimulation current needed to depolarise and evoke action potentials in the ganglion cells t...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/j.medengphy.2011.01.015
更新日期:2011-07-01 00:00:00
abstract::Large Eddy Simulation (LES) is performed to study the physiological pulsatile transition-to-turbulent non-Newtonian blood flow through a 3D model of arterial stenosis by using five different blood viscosity models: (i) Power-law, (ii) Carreau, (iii) Quemada, (iv) Cross and (v) modified-Casson. The computational domain...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/j.medengphy.2011.11.013
更新日期:2012-10-01 00:00:00
abstract::We studied muscle fatigue in 19 paraplegic patients during an isometric sustained contraction. Both quadriceps (n = 38) were maximally stimulated for 126 s. We defined a nonlinear equation with four coefficients to fit the data and extract fatigue indices carrying information on the amount (asymptotic values, torque c...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/s1350-4533(97)00038-6
更新日期:1997-12-01 00:00:00
abstract::The majority of the eye models developed in the late 90s and early 00s considers only heat conduction inside the eye. This assumption is not entirely correct, since the anterior and posterior chambers are filled aqueous humor (AH) that is constantly in motion due to thermally-induced buoyancy. In this paper, a three-d...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/j.medengphy.2016.05.011
更新日期:2016-08-01 00:00:00
abstract::This investigation explored pattern recognition of EMG signals produced by shoulder area muscles to identify the performance of a select number of lower arm motions. The signals were modelled as fourth-order autoregressive processes with the parameters of the models used to classify the different motions. The recorded...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/1350-4533(94)90024-8
更新日期:1994-03-01 00:00:00
abstract:OBJECTIVE:Mathematical modeling of cerebral hemodynamics by descriptive equations can estimate the underlying pulsatile component of cerebral arterial blood volume (CaBV). This way, clinical monitoring of changes in cerebral compartmental compliances becomes possible. Our aim is to validate the most adequate method of ...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/j.medengphy.2019.07.019
更新日期:2019-12-01 00:00:00
abstract::This study concerns the effects of different drilling parameters of pilot drills and twist drills on the temperature rise of alveolar bones during dental implant procedures. The drilling parameters studied here include the feed rate and rotation speed of the drill. The bone temperature distribution was analyzed throug...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/j.medengphy.2016.08.009
更新日期:2016-11-01 00:00:00
abstract::The prerequisite for the continuous in vivo monitoring of glucose concentration is the development of an implantable glucose sensor with long-term stability. A new enzyme electrode concept featuring fluid-state glucose oxidase modified carbon powder along with a cross-linked glucose oxidase enzyme layer has been devel...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/1350-4533(90)90008-v
更新日期:1994-09-01 00:00:00
abstract::The value of compliance of disposable elements such as infusion lines and syringes can significantly affect the performance characteristics of infusion devices. In a technique used to determine the compliance of infusion lines, the item under test is placed in a semi sealed water filled enclosure and the volume of flu...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/j.medengphy.2014.07.016
更新日期:2014-11-01 00:00:00
abstract::We developed a device for an objective measurement of non-nutritive sucking (NNS). NNS is newborns' spontaneous action that is a predictor of their neural system development and can be adopted as an intervention to train oral feeding skills in preterms. Two miniaturized digital pressure sensors were embedded into a co...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/j.medengphy.2015.12.013
更新日期:2016-04-01 00:00:00
abstract::We have developed a computer-based system to simulate a guidewire in blood vessels for surgical planning, intra-operative assistance, and to facilitate the design of new guidewires. In this study, we compared simulation results with experimental results for validation of the simulation system. First, we inserted a com...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/j.medengphy.2014.09.012
更新日期:2014-12-01 00:00:00
abstract::Since direct manual tissue palpation is not possible in laparoscopic surgery, feedback information on tactile tissue properties is considerably diminished. Restoring part of the surgeon's sense of touch through devices capable of providing artificial tactile feedback (ATF) is an active field of applied research and de...
journal_title:Medical engineering & physics
pub_type: 杂志文章,评审
doi:10.1016/j.medengphy.2009.06.003
更新日期:2009-10-01 00:00:00
abstract::Somatosensory evoked potential (SEP) testing has been widely applied to diagnosis of various neurological disorders. However, SEP recorded using surface electrodes is buried in noises, which makes the signal-to-noise ratio (SNR) very poor. Conventional averaging method usually requires up to thousands of raw SEP input...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/j.medengphy.2004.09.007
更新日期:2005-04-01 00:00:00
abstract::This proof-of-concept study designs distal femur fracture plates from semi-rigid materials vs. traditional metals for toe-touch weight-bearing recommended to patients immediately after surgery. The two-fold goal was to (a) reduce stress shielding (SS) by increasing cortical bone stress thereby reducing the risk of bon...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/j.medengphy.2020.11.015
更新日期:2021-01-01 00:00:00
abstract::Laser Ablation (LA) is a minimally-invasive procedure for tumor treatment. LA outcomes depend on the heat distribution inside tissues and require accurate temperature measurement during the procedure. Magnetic resonance imaging (MRI) allows a non-invasive and three-dimensional thermometry of the organ undergoing LA. I...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/j.medengphy.2015.04.001
更新日期:2015-07-01 00:00:00
abstract::In this study we integrated between confocal-based cell-specific finite element (FE) modeling and Virtual Cell (VC) transport simulations in order to determine trends of relationship between externally applied compressive deformations and build-up rates of oxygen in myoblast cells, and to further test how mild culture...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/j.medengphy.2011.04.008
更新日期:2011-11-01 00:00:00
abstract::The purpose of this study was to determine the accuracy of a radiographic model-based tracking technique that measures the three-dimensional in vivo motion of the tibio-femoral joint during running. Tantalum beads were implanted into the femur and tibia of three subjects and computed tomography (CT) scans were acquire...
journal_title:Medical engineering & physics
pub_type: 临床试验,杂志文章
doi:10.1016/j.medengphy.2008.03.003
更新日期:2009-01-01 00:00:00
abstract::Functional Electrical Stimulation (FES) is a well known clinical rehabilitation procedure, however the neural mechanisms that underlie this treatment at Central Nervous System (CNS) level are still not completely understood. Functional magnetic resonance imaging (fMRI) is a suitable tool to investigate effects of reha...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/j.medengphy.2011.04.005
更新日期:2011-10-01 00:00:00
abstract::This study tested the effectiveness of low-level laser therapy (LLLT) in preventing and/or treating osteoporotic trabecular bone. Mice were ovariectomized (OVX) to induce osteoporotic bone loss. The tibiae of eight OVX mice were treated for 5 days each week for 2 weeks by LLLT (660 nm, 3 J) using a minimally invasive ...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/j.medengphy.2012.10.002
更新日期:2013-07-01 00:00:00
abstract::The present investigation was conducted to see the effect of subcutaneous fat on the transmission characteristics of an electrical stimulus applied to the skin and conducted to skeletal muscle. Two groups of subjects participated. In one, the subjects were three males and three females whose average age was 24.6+/-1.5...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/j.medengphy.2008.02.009
更新日期:2008-11-01 00:00:00
abstract::The standard camera- and force plate-based set-up for motion analysis suffers from the disadvantage of being limited to laboratory settings. Since adaptive algorithms are able to learn the connection between known inputs and outputs and generalise this knowledge to unknown data, these algorithms can be used to leverag...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/j.medengphy.2020.10.001
更新日期:2020-12-01 00:00:00
abstract::Cutting and drilling operations in bone are involved in many orthopedic and otolaryngological surgeries. The temperature elevation of these procedures is potentially harmful to bone and soft tissue cells. The research on this topic aims therefore at minimizing temperature elevation and finding optimal process paramete...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/j.medengphy.2016.06.019
更新日期:2016-10-01 00:00:00
abstract::This paper presents a sensor for monitoring and controlling the volume of the cerebrospinal fluid-filled ventricles of the brain. The measurement principle of the sensor exploits electrical conductivity differences between the cerebrospinal fluid and the brain tissue. The electrical contrast was validated using dog br...
journal_title:Medical engineering & physics
pub_type: 杂志文章
doi:10.1016/j.medengphy.2009.03.011
更新日期:2009-09-01 00:00:00