Seasonal trivalent inactivated influenza vaccine does not protect against newly emerging variants of influenza A (H3N2v) virus in ferrets.

abstract：:Since 1998, 9 of the 26 serotypes of bluetongue virus (BTV) have spread throughout Europe, and serotype 8 has suddenly emerged in northern Europe, causing considerable economic losses, direct (mortality and morbidity) but also indirect, due to restriction in animal movements. Therefore, many new types of vaccines, par...

journal_title：Journal of virology

authors： Celma CC,Boyce M,van Rijn PA,Eschbaumer M,Wernike K,Hoffmann B,Beer M,Haegeman A,De Clercq K,Roy P

更新日期：2013-09-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a cluster of 12 microRNAs (miRNAs) that are processed from a transcript that is embedded within the major latency control region. We have generated a deletion mutation that eliminates 10 of the 12 viral miRNAs from the KSHV bacmid by using recombineering methods. ...

journal_title：Journal of virology

authors： Lu F,Stedman W,Yousef M,Renne R,Lieberman PM

更新日期：2010-03-01 00:00:00

abstract：:Epstein-Barr virus (EBV) SM protein is an essential nuclear shuttling protein expressed by EBV early during the lytic phase of replication. SM acts to increase EBV lytic gene expression by binding EBV mRNAs and enhancing accumulation of the majority of EBV lytic cycle mRNAs. SM increases target mRNA stability and nucl...

journal_title：Journal of virology

authors： Han Z,Verma D,Hilscher C,Dittmer DP,Swaminathan S

更新日期：2009-11-01 00:00:00

abstract：:Mounting evidence suggests that human immunodeficiency virus type 1 (HIV-1) Gag-specific T helper cells contribute to effective antiviral control, but their functional characteristics and the precise epitopes targeted by this response remain to be defined. In this study, we generated CD4(+) T-cell clones specific for ...

journal_title：Journal of virology

authors： Norris PJ,Sumaroka M,Brander C,Moffett HF,Boswell SL,Nguyen T,Sykulev Y,Walker BD,Rosenberg ES

更新日期：2001-10-01 00:00:00

abstract：:Retroviral Gag proteins have the ability to induce budding and particle release from the plasma membrane when expressed in the absence of all of the other virus-encoded components; however, the locations of the functional domains within the Gag protein that are important for this process are poorly understood. It was ...

journal_title：Journal of virology

authors： Weldon RA Jr,Wills JW

更新日期：1993-09-01 00:00:00

abstract：:Arenaviruses can cause lethal hemorrhagic fevers in humans with few preventative and therapeutic measures. The arenaviral glycoprotein stable signal peptide (SSP) is unique among signal peptides in that it is an integral component of the mature glycoprotein complex (GPC) and plays important roles not only in GPC expre...

journal_title：Journal of virology

authors： Shao J,Liu X,Ly H,Liang Y

更新日期：2016-10-28 00:00:00

abstract：:Nonstructural protein 5A (NS5A) is a membrane-associated essential component of the hepatitis C virus (HCV) replication complex. An N-terminal amphipathic alpha helix mediates in-plane membrane association of HCV NS5A and at the same time is likely involved in specific protein-protein interactions required for the ass...

journal_title：Journal of virology

authors： Brass V,Pal Z,Sapay N,Deléage G,Blum HE,Penin F,Moradpour D

更新日期：2007-03-01 00:00:00

abstract：:Chaperone-enriched domains are formed in the nuclei of cells lytically infected with herpes simplex virus type 1 (HSV-1). These domains, called VICE, for virus induced chaperone enriched, contain Hsc70, Hsp70, Hsp40, Hsp90, polyubiquitinated proteins, and components of the proteasome machinery. Accumulating evidence i...

journal_title：Journal of virology

authors： Mathew SS,Della Selva MP,Burch AD

更新日期：2009-09-01 00:00:00

abstract：:The RNA genomes from the cardioviruses, hepatoviruses, and aphthoviruses encode two to five tandem pseudoknots within their 5' untranslated regions. These pseudoknots lie adjacent to a pyrimidine-rich sequence, which in cardio- and aphthoviruses takes the form of a homopolymeric poly(C) tract. Seven deletion mutations...

journal_title：Journal of virology

authors： Martin LR,Palmenberg AC

更新日期：1996-11-01 00:00:00

abstract：:Human papillomavirus type 18 (HPV18) and HPV45 account for approximately 20% of all cervix cancers. We show that HPV18, HPV45, and the recently discovered HPV97 comprise a clade sharing a most recent common ancestor within HPV alpha7 species. Variant lineages of these HPV types were classified by sequence analysis of ...

journal_title：Journal of virology

authors： Chen Z,DeSalle R,Schiffman M,Herrero R,Burk RD

更新日期：2009-02-01 00:00:00

abstract：:We have used cDNA arrays to compare the activation of various cellular genes in response to infection with Sendai viruses (SeV) that contain specific mutations. Three groups of cellular genes activated by mutant SeV infection, but not by wild-type SeV, were identified in this way. While some of these genes are well kn...

journal_title：Journal of virology

authors： Strähle L,Garcin D,Le Mercier P,Schlaak JF,Kolakofsky D

更新日期：2003-07-01 00:00:00

abstract：:Infection with severe acute respiratory syndrome coronavirus (SARS-CoV) causes acute lung injury (ALI) that often leads to severe lung disease. A mouse model of acute SARS-CoV infection has been helpful in understanding the host response to infection; however, there are still unanswered questions concerning SARS-CoV p...

journal_title：Journal of virology

authors： Page C,Goicochea L,Matthews K,Zhang Y,Klover P,Holtzman MJ,Hennighausen L,Frieman M

更新日期：2012-12-01 00:00:00

abstract：:Some retroviruses contain monoubiquitinated Gag and do not bud efficiently from cells treated with proteasome inhibitors, suggesting an interaction between the ubiquitin-proteasome system and retrovirus assembly. We examined equine infectious anemia virus (EIAV) particles and found that approximately 2% of the p9(Gag)...

journal_title：Journal of virology

authors： Ott DE,Coren LV,Sowder RC 2nd,Adams J,Nagashima K,Schubert U

更新日期：2002-03-01 00:00:00

abstract：UNLABELLED:The western honeybee (Apis mellifera) is the most important commercial insect pollinator. However, bees are under pressure from habitat loss, environmental stress, and pathogens, including viruses that can cause lethal epidemics. Slow bee paralysis virus (SBPV) belongs to the Iflaviridae family of nonenvelop...

journal_title：Journal of virology

authors： Kalynych S,Přidal A,Pálková L,Levdansky Y,de Miranda JR,Plevka P

更新日期：2016-07-27 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) establishes lifelong latent infections in neurons. Reactivation from latency can lead to serious recurrent disease, including stromal keratitis, corneal scarring, blindness, and encephalitis. Although numerous studies link stress to an increase in the incidence of reactivation from laten...

journal_title：Journal of virology

authors： Harrison KS,Zhu L,Thunuguntla P,Jones C

更新日期：2019-06-14 00:00:00

abstract：:H.-H. Lu and E. Wimmer (Proc. Natl. Acad. Sci. USA 93:1412-1417, 1996) have demonstrated that the internal ribosomal entry site (IRES) of poliovirus (PV) can be functionally replaced by the related genetic element from hepatitis C virus (HCV). One important finding of this study was that open reading frame sequences 3...

journal_title：Journal of virology

authors： Zhao WD,Wimmer E,Lahser FC

更新日期：1999-02-01 00:00:00

abstract：UNLABELLED:Human cytomegalovirus (HCMV) is a major cause of morbidity and mortality in transplant patients and is the leading viral cause of birth defects after congenital infection. HCMV infection relies on the recognition of cell-specific receptors by one of the viral envelope glycoprotein complexes. Either the gH/gL...

journal_title：Journal of virology

authors： Caló S,Cortese M,Ciferri C,Bruno L,Gerrein R,Benucci B,Monda G,Gentile M,Kessler T,Uematsu Y,Maione D,Lilja AE,Carfí A,Merola M

更新日期：2016-04-29 00:00:00

abstract：:The Epstein-Barr virus nuclear antigen 2 (EBNA-2) acidic domain is essential for B-lymphocyte growth transformation and can activate transcription when brought to a promoter by a sequence-specific DNA-binding domain. We now show that the EBNA-2 acidic domain has slightly less activity than the proteotypic acidic trans...

journal_title：Journal of virology

authors： Tong X,Wang F,Thut CJ,Kieff E

更新日期：1995-01-01 00:00:00

abstract：:Mutations critical for the central nervous system (CNS) attenuation of the Sabin vaccine strains of poliovirus (PV) are located within the viral internal ribosome entry site (IRES). We examined the interaction of the IRESs of PV type 3 (PV3) and Sabin type 3 (Sabin3) with polypyrimidine tract-binding protein (PTB) and...

journal_title：Journal of virology

authors： Guest S,Pilipenko E,Sharma K,Chumakov K,Roos RP

更新日期：2004-10-01 00:00:00

abstract：:We have analyzed three cases of hepatitis C virus (HCV)-infected recipients who received blood from HCV-infected donors. Two recipients were exposed to two different HCV RNA-positive donors, and one was exposed to a single donor. All parental genomes from the actual infecting units of blood and the recipients were def...

journal_title：Journal of virology

authors： Laskus T,Wang LF,Radkowski M,Vargas H,Nowicki M,Wilkinson J,Rakela J

更新日期：2001-03-01 00:00:00

abstract：:Cytomegalovirus (CMV) disease after bone marrow (BM) transplantation is often associated with BM graft failure. There are two possible reasons for such a correlation. First, a poor hematopoietic reconstitution of unrelated etiology could promote the progression of CMV infection by the lack of immune control. Alternati...

journal_title：Journal of virology

authors： Steffens HP,Podlech J,Kurz S,Angele P,Dreis D,Reddehase MJ

更新日期：1998-06-01 00:00:00

abstract：:The host cell receptor for Moloney murine leukemia virus was solubilized from murine L-cell membranes and characterized. In initial studies designed to identify a receptor-rich cell line, different mouse cells were screened for binding to Moloney gp70, the viral envelope glycoprotein which determines host cell-binding...

journal_title：Journal of virology

authors： Johnson PA,Rosner MR

更新日期：1986-06-01 00:00:00

abstract：:Regulation of immediate-early gene expression in human cytomegalovirus is subject to complex controls. The major immediate-early (mIE) gene is regulated by both positive and negative regulatory signals, including autoregulation mediated by a cis-repressive sequence. A second immediate-early gene, the US3 gene, is tran...

journal_title：Journal of virology

authors： Biegalke BJ

更新日期：1995-09-01 00:00:00

abstract：:A system has been developed for generating chimeric yellow fever/Japanese encephalitis (YF/JE) viruses from cDNA templates encoding the structural proteins prM and E of JE virus within the backbone of a molecular clone of the YF17D strain. Chimeric viruses incorporating the proteins of two JE strains, SA14-14-2 (human...

journal_title：Journal of virology

authors： Chambers TJ,Nestorowicz A,Mason PW,Rice CM

更新日期：1999-04-01 00:00:00

abstract：:Endogenous retroviruses (ERV) are found throughout vertebrate genomes, and failure to silence their activation can have deleterious consequences on the host. Mutation and subsequent disruption of ERV loci is therefore an indispensable component of the cell-intrinsic defenses that maintain the integrity of the host gen...

journal_title：Journal of virology

authors： Treger RS,Tokuyama M,Dong H,Salas-Briceno K,Ross SR,Kong Y,Iwasaki A

更新日期：2019-09-30 00:00:00

abstract：:We report the identification of a functional nuclear localization signal (NLS) in the human cytomegalovirus (HCMV) large tegument protein pUL48 that is required for nuclear localization in transfected cells and is essential for viral growth. The NLS was mapped to pUL48 amino acid residues 284 to 302. This sequence con...

journal_title：Journal of virology

authors： Brock I,Krüger M,Mertens T,von Einem J

更新日期：2013-05-01 00:00:00

abstract：:Nucleocapsids were isolated from purified enveloped nucleocapsids of Plodia interpunctella granulosis virus by treatment with Nonidet P-40. When analyzed on sodium dodecyl sulfate-polyacrylamide gels, the nucleocapsids consisted of eight polypeptides. One of these, a major component with a molecular weight of 12,500 (...

journal_title：Journal of virology

authors： Tweeten KA,Bulla LA,Consigli RA

更新日期：1980-02-01 00:00:00

abstract：:Vaccinia extracellular enveloped virus (EEV) is critical for cell-to-cell and long-range virus spread both in vitro and in vivo. The B5R gene encodes an EEV-specific type I membrane protein that is essential for efficient EEV formation. The majority of the B5R ectodomain consists of four domains with homology to short...

journal_title：Journal of virology

authors： Aldaz-Carroll L,Whitbeck JC,Ponce de Leon M,Lou H,Hirao L,Isaacs SN,Moss B,Eisenberg RJ,Cohen GH

更新日期：2005-05-01 00:00:00

abstract：:We used a transfected L cell and a vaccinia vector carrying the herpes simplex virus type 1 (HSV-1) gene coding for glycoprotein D (gD) to characterize HSV-specific T-cell responses. Various studies with mice revealed that the vectors could stimulate some HSV-specific T-cell responses. Although the majority of the T c...

journal_title：Journal of virology

authors： Martin S,Moss B,Berman PW,Laskey LA,Rouse BT

更新日期：1987-03-01 00:00:00

abstract：:The simian-human immunodeficiency virus SHIV-HXBc2 contains the envelope glycoproteins of a laboratory-adapted, neutralization-sensitive human immunodeficiency virus type 1 variant, HXBc2. Serial in vivo passage of the nonpathogenic SHIV-HXBc2 generated SHIV KU-1, which causes rapid CD4(+) T-cell depletion and an AIDS...

journal_title：Journal of virology

authors： Si Z,Cayabyab M,Sodroski J

更新日期：2001-05-01 00:00:00