Abstract:
:We have analyzed three cases of hepatitis C virus (HCV)-infected recipients who received blood from HCV-infected donors. Two recipients were exposed to two different HCV RNA-positive donors, and one was exposed to a single donor. All parental genomes from the actual infecting units of blood and the recipients were defined, and their presence in the follow-up serum samples was determined using sensitive strain-specific assays. The strain from one of the donors was found to predominate in all recipients' serum samples collected throughout the follow-up period of 10 to 30 months. In two recipients exposed to two infected donors, the strain from the second donor was occasionally found at very low level. However, the original recipients' strains were not detected. Our observations show that HCV-infected individuals can be superinfected with different strains, and this event may lead to eradication or suppression of the original infecting strain. Furthermore, our findings demonstrate that simultaneous exposure to multiple HCV strains may result in concomitant infection by more than one strain, although a single strain could rapidly establish its dominance. The results of the present study suggest the existence of competition among infecting HCV strains which determines the ultimate outcome of multiple HCV exposure.
journal_name
J Viroljournal_title
Journal of virologyauthors
Laskus T,Wang LF,Radkowski M,Vargas H,Nowicki M,Wilkinson J,Rakela Jdoi
10.1128/JVI.75.5.2059-2066.2001subject
Has Abstractpub_date
2001-03-01 00:00:00pages
2059-66issue
5eissn
0022-538Xissn
1098-5514journal_volume
75pub_type
杂志文章abstract:UNLABELLED:Kaposi's sarcoma-associated herpesvirus (KSHV) infection is required for the development of several AIDS-related malignancies, including Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL). The high incidence of AIDS-KS has been ascribed to the interaction of KSHV and HIV-1. We have previously shown th...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00797-16
更新日期:2016-09-12 00:00:00
abstract::H.-H. Lu and E. Wimmer (Proc. Natl. Acad. Sci. USA 93:1412-1417, 1996) have demonstrated that the internal ribosomal entry site (IRES) of poliovirus (PV) can be functionally replaced by the related genetic element from hepatitis C virus (HCV). One important finding of this study was that open reading frame sequences 3...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.2.1546-1554.1999
更新日期:1999-02-01 00:00:00
abstract::A adenovirus type 5 host range mutant (hr440) has been isolated which is defective in a splicing event required to generate the middle-sized mRNA from early region 1A. This defect has been ascribed to two adjacent nucleotide changes which lie five and six nucleotides from the 5' splice site for this mRNA (Solnick, Nat...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.42.1.106-113.1982
更新日期:1982-04-01 00:00:00
abstract:UNLABELLED:The first discovered and sequenced hepatitis C virus (HCV) genome and the first in vivo infectious HCV clones originated from the HCV prototype strains HCV-1 and H77, respectively, both widely used in research of this important human pathogen. In the present study, we developed efficient infectious cell cult...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02877-14
更新日期:2015-01-01 00:00:00
abstract::We previously observed that when human immunodeficiency virus (HIV)-infected T lymphocytes are added to epithelial cells, they adhere, polarize, and secrete virions unidirectionally onto the epithelium. Epithelial cells subsequently take up virus and become productively infected. We report here that colchicine treatme...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.68.5.2898-2905.1994
更新日期:1994-05-01 00:00:00
abstract::Swainsonine, an inhibitor of glycoprotein processing, inhibits the formation of the normal oligosaccharide chain of the G protein of vesicular stomatitis virus. Thus, when vesicular stomatitis virus was grown in baby hamster kidney cells in the presence of swainsonine (15 to 500 ng/ml) and labeled with [2-(3)H]mannose...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.46.1.60-69.1983
更新日期:1983-04-01 00:00:00
abstract:UNLABELLED:Generalized immune activation during HIV infection is associated with an increased risk of cardiovascular disease, neurocognitive disease, osteoporosis, metabolic disorders, and physical frailty. The mechanisms driving this immune activation are poorly understood, particularly for individuals effectively tre...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01257-14
更新日期:2014-08-01 00:00:00
abstract:UNLABELLED:Cell culture systems reproducing virus replication can serve as unique models for the discovery of novel bioactive molecules. Here, using a hepatitis C virus (HCV) cell culture system, we identified neoechinulin B (NeoB), a fungus-derived compound, as an inhibitor of the liver X receptor (LXR). NeoB was init...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00856-16
更新日期:2016-09-29 00:00:00
abstract::Although the etiology of multiple sclerosis (MS) is not known, several factors play a role in this disease: genetic contributions, immunologic elements, and environmental factors. Viruses and virus infections have been associated with the initiation and/or enhancement of exacerbations in MS. Theiler's murine encephalo...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.73.2.993-1000.1999
更新日期:1999-02-01 00:00:00
abstract::Epithelial cells lining mucosal surfaces impose multiple barriers to viral infection. At the ocular surface, the carbohydrate-binding protein galectin-3 maintains barrier function by cross-linking transmembrane mucins on the apical glycocalyx. Despite these defense mechanisms, many viruses have evolved to exploit fund...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00166-13
更新日期:2013-05-01 00:00:00
abstract::The ribonucleoprotein (RNP) internal components of influenza virus were separated into distinct size classes by sedimentation in glycerol gradients and examined by electron microscopy by using positive staining with uranyl acetate. The large RNP have a peak in length distribution at 90 to 110 nm, the medium, at 60 to ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.10.4.795-800.1972
更新日期:1972-10-01 00:00:00
abstract::To explore the roles played by specific human immunodeficiency virus type 1 (HIV-1) genes in determining the in vivo replicative capacity of AIDS viruses, we have examined the replication kinetics and virus-specific immune responses in rhesus monkeys following infection with two chimeric simian/human immunodeficiency ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.70.5.3198-3206.1996
更新日期:1996-05-01 00:00:00
abstract::Our laboratory has previously reported isolation of human rhinovirus type 16 (HRV16) mutants which depend on WIN 52035 to grow. A rapid rise of progeny virus infectivity occurred when drug was added late in growth cycles, suggesting that the drug-dependence lesion was at the step of virus assembly (W. Wang et al., J. ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.77.11.6235-6244.2003
更新日期:2003-06-01 00:00:00
abstract::Recently developed antiviral strategies based upon RNA interference (RNAi), which harnesses an innate cellular system for the targeted down-regulation of gene expression, appear highly promising and offer alternative approaches to conventional highly active antiretroviral therapy or efforts to develop an AIDS vaccine....
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.3.1645-1654.2005
更新日期:2005-02-01 00:00:00
abstract::Human adenovirus 41 (HAdV-41) causes acute gastroenteritis in young children. The main characteristics of HAdV-41 infection are diarrhea and vomiting. Nevertheless, the precise mechanism of HAdV-41-induced diarrhea is unknown, as a suitable small-animal model has not been described. In this study, we used the human mi...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00026-18
更新日期:2018-03-14 00:00:00
abstract::We showed previously that retrovirus vector particles can encapsidate RNAs without retroviral cis-acting sequences, that such RNAs are reverse transcribed in infected target cells, and that the cDNA copies are inserted into the host genome resulting in cDNA genes (R. Dornburg and H. M. Temin, Mol. Cell. Biol. 8:2328-2...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.64.2.886-889.1990
更新日期:1990-02-01 00:00:00
abstract::We studied the capacity of active immunization of rhesus monkeys with HIV-1 envelope protein (Env) to induce primary virus cross-reactive neutralizing antibodies to prevent infection following intravenous challenge with simian-human immunodeficiency virus (SHIV). Monkeys were immunized with the human immunodeficiency ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.79.6.3358-3369.2005
更新日期:2005-03-01 00:00:00
abstract::The enhancer of human papillomavirus type 16 (HPV-16) is considered to be specific for epithelial cells, in particular for cervical carcinoma-derived cell lines. We reexamined this hypothesis with the complete enhancer as well as nonoverlapping subclones and found all clones to be active in epithelial cell lines deriv...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.65.11.5933-5943.1991
更新日期:1991-11-01 00:00:00
abstract::Transgenic mice expressing the simian virus 40 large T antigen (TAg) in enterocytes develop intestinal hyperplasia that progresses to dysplasia with age. This induction requires TAg action on the retinoblastoma (Rb) family of tumor suppressors and is independent of the p53 pathway. In cell culture systems, the inactiv...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00922-07
更新日期:2007-09-01 00:00:00
abstract::HIV-1's Rev protein forms a homo-oligomeric adaptor complex linking viral RNAs to the cellular CRM1/Ran-GTP nuclear export machinery through the activity of Rev's prototypical leucine-rich nuclear export signal (NES). In this study, we used a functional fluorescently tagged Rev fusion protein as a platform to study th...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02107-16
更新日期:2017-01-18 00:00:00
abstract::Dengue virus (DEN) causes dengue fever and dengue hemorrhagic fever/dengue shock syndrome, which are major public health problems worldwide. The immune factors that control DEN infection or contribute to severe disease are neither well understood nor easy to examine in humans. In this study, we used wild-type and cong...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.78.6.2701-2710.2004
更新日期:2004-03-01 00:00:00
abstract::The experimental infection of newborn calves with bovine norovirus was used as a homologous large animal model to study the pathogenesis of norovirus infection and to determine target cells for viral replication. Six newborn calves were inoculated orally with Jena virus (JV), a bovine norovirus GIII.1 strain, and six ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.05342-11
更新日期:2011-11-01 00:00:00
abstract::The novel low-pathogenic avian influenza A H7N9 viruses (LPAI H7N9 viruses) have been a threat to public health since their emergence in 2013 because of the high rates of mortality and morbidity that they cause. Recently, highly pathogenic variants of these avian influenza A H7N9 viruses (HPAI H7N9 viruses) have emerg...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01277-17
更新日期:2017-11-14 00:00:00
abstract::Hantaviruses are rodent-borne agents that cause hemorrhagic fever with renal syndrome or hantavirus pulmonary syndrome in humans. The nucleocapsid protein (N) is relatively conserved among hantaviruses and highly immunogenic in both laboratory animals and humans, and it has been shown to induce efficient protective im...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/jvi.76.13.6669-6677.2002
更新日期:2002-07-01 00:00:00
abstract::Primary infection of a plant with a pathogen that causes high accumulation of salicylic acid in the plant typically via a hypersensitive response confers enhanced resistance against secondary infection with a broad spectrum of pathogens, including viruses. This phenomenon is called systemic acquired resistance (SAR), ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00761-17
更新日期:2017-09-12 00:00:00
abstract::Live-attenuated vesicular stomatitis virus (VSV) vectors expressing foreign antigens induce potent immune responses and protect against viral diseases in animal models. Highly attenuated (VSV-CT1) or single-cycle VSV (VSVDeltaG) vectors induce immune responses lower than those generated by attenuated wild-type VSV vec...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.02525-06
更新日期:2007-02-01 00:00:00
abstract::Interferon (IFN)-stimulated gene factor 2 (ISGF2) plays a role in transcription of the beta IFN (IFN-beta) gene and IFN-stimulated genes (ISGs) and may function as a central mediator of cytokine responses. Constitutive ISGF2 transgene expression resulted in substantial resistance to three RNA virus families. This phen...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.66.7.4470-4478.1992
更新日期:1992-07-01 00:00:00
abstract::Virus entry into host cells is a complex process that is largely regulated by access to specific cellular receptors. Human adenoviruses (HAdVs) and many other viruses use cell adhesion molecules such as the coxsackievirus and adenovirus receptor (CAR) for attachment to and entry into target cells. These molecules are ...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.00542-20
更新日期:2020-07-01 00:00:00
abstract::Dengue virus (DENV) and hepatitis C virus (HCV), members of the family Flaviviridae, are global human health concerns. As positive-strand RNA viruses, they each replicate in the cytoplasm of infected cells and induce distinct membranous replication compartments where most, if not all, steps of the viral life cycle occ...
journal_title:Journal of virology
pub_type: 杂志文章,评审
doi:10.1128/JVI.03404-13
更新日期:2014-06-01 00:00:00
abstract::It is well known that plasmid DNA transfection, prior to virus infection, negatively affects infection efficiency. Here, we show that cytosolic plasmid DNA activates the cGAS/STING signaling pathway, which ultimately leads to the induction of an antiviral state of the cells. Using a transient one-plasmid clustered reg...
journal_title:Journal of virology
pub_type: 杂志文章
doi:10.1128/JVI.01781-15
更新日期:2015-11-01 00:00:00