Abstract：
BACKGROUND:The optimal situation in external quality assessment (EQA) is to use commutable materials. No previous study has examined the commutability of a whole-blood material for point-of-care (POC) testing. The aim of this study was to determine the commutability of the Norwegian Quality Improvement of Laboratory Examinations (Noklus) organization's "in-house" whole-blood EQA material for C-reactive protein (CRP), glucose, and hemoglobin for frequently used POC instruments in Norway and to determine the possibility of using a common target value for each analyte. METHODS:The study was performed according to the Clinical and Laboratory Standards Institute guidelines. The EQA material was pooled stabilized EDTA venous whole-blood containing different concentrations of the analytes. The EQA material and native routine patient samples were analyzed using 17 POC and 3 hospital instruments. The commutability was assessed using Deming regression analysis with 95% prediction intervals for each instrument comparison. RESULTS:The EQA material was commutable for all CRP and hemoglobin POC instruments, whereas for glucose the material was commutable for all POC instruments at the lowest concentration analyzed [126.0 mg/dL (7.0 mmol/L)] and for 3 POC instruments at all of the concentrations analyzed. CONCLUSIONS:Noklus EQA participants using CRP and hemoglobin POC instruments now receive results that are compared with a reference target value, whereas the results for participants using glucose POC instruments are still compared with method-specific target values. Systematic deviations from a reference target value for the commutable glucose POC instruments can be calculated, and this additional information can now be offered to these participants and to the manufacturers.
journal_name
Clin Chemjournal_title
Clinical chemistryauthors
Bukve T,Sandberg S,Vie WS,Sølvik U,Christensen NG,Stavelin Adoi
10.1373/clinchem.2018.300202subject
Has Abstractpub_date
2019-06-01 00:00:00pages
791-797issue
6eissn
0009-9147issn
1530-8561pii
clinchem.2018.300202journal_volume
65pub_type
杂志文章abstract：:The concentrations of 25 plasma proteins were measured in 22 patients with membranous nephropathy. For some large proteins, the plasma concentrations were increased; there were also large proteins with low plasma concentrations, but small or medium-sized proteins showed uniformly lower plasma concentration than the co...
journal_title：Clinical chemistry
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journal_title：Clinical chemistry
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journal_title：Clinical chemistry
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doi：
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doi：
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更新日期：1979-03-01 00:00:00
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doi：
更新日期：1976-07-01 00:00:00
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doi：
更新日期：1997-09-01 00:00:00
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doi：
更新日期：2002-05-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1992-03-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1977-01-01 00:00:00
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doi：10.1373/clinchem.2007.099424
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journal_title：Clinical chemistry
pub_type： 杂志文章
doi：
更新日期：1987-12-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1979-05-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1984-05-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1992-02-01 00:00:00
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journal_title：Clinical chemistry
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doi：
更新日期：1986-09-01 00:00:00
abstract：:A potential genetic marker for hypertriglyceridemia and coronary disease, an apolipoprotein-CIII gene allele displaying a single nucleotide substitution, was found in 71% of Arabs with primary hypertriglyceridemia. Over 96% of the unrelated adults possessing this allele showed hypertriglyceridemia. The same allele was...
journal_title：Clinical chemistry
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doi：
更新日期：1989-02-01 00:00:00
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journal_title：Clinical chemistry
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doi：
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journal_title：Clinical chemistry
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doi：
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journal_title：Clinical chemistry
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doi：
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