Experimental pediatric arterial ischemic stroke model reveals sex-specific estrogen signaling.

Abstract:

BACKGROUND AND PURPOSE:Pediatric stroke, birth to 18 years, is a significant cause of long-term disability in the United States; however, there is currently little experimental data on the pathophysiology of childhood stroke owing to lack of animal models. We developed a novel mouse model of experimental childhood-onset arterial ischemic stroke to characterize the sex-specific response of the adolescent brain to cerebral ischemia and assess the neuroprotective effect of estrogen at this developmental stage. METHODS:Postnatal day 20 to 25 mice were subjected to 90 minutes experimental stroke via the intraluminal filament middle cerebral artery occlusion model and ischemic damage assessed 22 hours after reperfusion. Real-time quantitative real-time polymerase chain reaction was performed 22 hours after middle cerebral artery occlusion to determine the effects of ischemia and estrogen treatment on the proapoptotic gene Bax. RESULTS:Ischemic injury did not differ between male and female juvenile (postnatal day 20-25) mice after middle cerebral artery occlusion. However, estrogen reduced ischemic injury in female mice, whereas having no effect in juvenile males. No differences in estrogen receptor expression were observed on postnatal day between 20 males and females. In contrast, estrogen minimized the ischemia-induced increase in the proapoptotic gene Bax in female mice, whereas having no effect on Bax induction in the male brain. CONCLUSIONS:Focal ischemia has fundamentally different effects in the juvenile brain compared with the adult, as evidenced by the lack of sex difference in ischemic injury in the murine postnatal day 20 to 25 middle cerebral artery occlusion model and the sexually dimorphic response to estrogen neuroprotection.

journal_name

Stroke

journal_title

Stroke

authors

Herson PS,Bombardier CG,Parker SM,Shimizu T,Klawitter J,Klawitter J,Quillinan N,Exo JL,Goldenberg NA,Traystman RJ

doi

10.1161/STROKEAHA.112.675124

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

759-63

issue

3

eissn

0039-2499

issn

1524-4628

pii

STROKEAHA.112.675124

journal_volume

44

pub_type

杂志文章

相关文献

STROKE文献大全
  • Valid items for screening dysphagia risk in patients with stroke: a systematic review.

    abstract:BACKGROUND AND PURPOSE:Screening for dysphagia is essential to the implementation of preventive therapies for patients with stroke. A systematic review was undertaken to determine the evidence-based validity of dysphagia screening items using instrumental evaluation as the reference standard. METHODS:Four databases fr...

    journal_title:Stroke

    pub_type: 杂志文章,meta分析,评审

    doi:10.1161/STROKEAHA.111.640946

    authors: Daniels SK,Anderson JA,Willson PC

    更新日期:2012-03-01 00:00:00

  • Obesity increases risk of ischemic stroke in young adults.

    abstract:BACKGROUND AND PURPOSE:Body mass index has been associated with ischemic stroke in older populations, but its association with stroke in younger populations is not known. In light of the current obesity epidemic in the United States, the potential impact of obesity on stroke risk in young adults deserves attention. ME...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1161/STROKEAHA.115.008940

    authors: Mitchell AB,Cole JW,McArdle PF,Cheng YC,Ryan KA,Sparks MJ,Mitchell BD,Kittner SJ

    更新日期:2015-06-01 00:00:00

  • Validity of shape as a predictive biomarker of final infarct volume in acute ischemic stroke.

    abstract:BACKGROUND AND PURPOSE:This study examines whether lesion shape documented on magnetic resonance diffusion-weighted imaging during acute stroke improves the prediction of the final infarct volume compared with lesion volume only. METHODS:Diffusion-weighted imaging data and clinical information were retrospectively rev...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.114.008046

    authors: Frindel C,Rouanet A,Giacalone M,Cho TH,Østergaard L,Fiehler J,Pedraza S,Baron JC,Wiart M,Berthezène Y,Nighoghossian N,Rousseau D

    更新日期:2015-04-01 00:00:00

  • Predictors of Outcome in Aneurysmal Subarachnoid Hemorrhage Patients: Observations From a Multicenter Data Set.

    abstract:BACKGROUND AND PURPOSE:The mortality and morbidity after aneurysmal subarachnoid hemorrhage has improved because of better diagnosis, early treatment to secure the aneurysm, and better management of disease-specific complications. With these improvements in care, it is not clear if the previously identified independent...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/STROKEAHA.117.017777

    authors: Galea JP,Dulhanty L,Patel HC,UK and Ireland Subarachnoid Hemorrhage Database Collaborators.

    更新日期:2017-11-01 00:00:00

  • Lamotrigine protects hippocampal CA1 neurons from ischemic damage after cardiac arrest.

    abstract:BACKGROUND AND PURPOSE:Lamotrigine (LTG) is an anticonvulsant drug whose mechanism of action may involve the inhibition of glutamate release by blocking voltage-dependent sodium channels. Glutamate neurotoxicity may contribute to cerebral ischemic damage after recovery from cardiac arrest. Thus, LTG may prevent the bra...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.28.11.2230

    authors: Crumrine RC,Bergstrand K,Cooper AT,Faison WL,Cooper BR

    更新日期:1997-11-01 00:00:00

  • Predictors of good clinical outcomes, mortality, and successful revascularization in patients with acute ischemic stroke undergoing thrombectomy: pooled analysis of the Mechanical Embolus Removal in Cerebral Ischemia (MERCI) and Multi MERCI Trials.

    abstract:BACKGROUND AND PURPOSE:The Mechanical Embolus Removal in Cerebral Ischemia (MERCI) and Multi MERCI trials evaluated the safety and efficacy of thrombectomy in the treatment of intracranial arterial occlusions within 8 hours of symptom onset. We sought to determine the predictors of clinical and angiographic outcomes in...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.109.561431

    authors: Nogueira RG,Liebeskind DS,Sung G,Duckwiler G,Smith WS,MERCI.,Multi MERCI Writing Committee.

    更新日期:2009-12-01 00:00:00

  • Age-related changes in release of endothelium-derived relaxing factor from the carotid artery.

    abstract:BACKGROUND AND PURPOSE:The goal of this study was to determine whether release of endothelium-derived relaxing factor (EDRF) from carotid artery in response to acetylcholine is altered by aging. METHODS:Responses were examined in arteries from Wistar rats 6 to 8 months old (young rats), 24 to 26 months old (old rats),...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.25.12.2457

    authors: Paternò R,Faraci FM,Heistad DD

    更新日期:1994-12-01 00:00:00

  • Effects of locomotion training with assistance of a robot-driven gait orthosis in hemiparetic patients after stroke: a randomized controlled pilot study.

    abstract:BACKGROUND AND PURPOSE:The success of gait rehabilitation after stroke depends on active walking exercises. However, the disabling after-effects of stroke often make such exercises impossible at the onset of therapy. To facilitate treadmill training of paraparetic patients, a robot-driven gait orthosis (Lokomat) was de...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/01.STR.0000254607.48765.cb

    authors: Husemann B,Müller F,Krewer C,Heller S,Koenig E

    更新日期:2007-02-01 00:00:00

  • Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland.

    abstract:BACKGROUND AND PURPOSE:Elevated plasma homocysteine level has been associated with increased risk for cardiovascular and cerebrovascular disease. Variation in the levels of this amino acid has been shown to be due to nutritional status and methylenetetrahydrofolate reductase (MTHFR) genotype. METHODS:Under a case-cont...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.0000032550.90046.38

    authors: McIlroy SP,Dynan KB,Lawson JT,Patterson CC,Passmore AP

    更新日期:2002-10-01 00:00:00

  • THSD1 (Thrombospondin Type 1 Domain Containing Protein 1) Mutation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage.

    abstract:BACKGROUND AND PURPOSE:A ruptured intracranial aneurysm (IA) is the leading cause of a subarachnoid hemorrhage. This study seeks to define a specific gene whose mutation leads to disease. METHODS:More than 500 IA probands and 100 affected families were enrolled and clinically characterized. Whole exome sequencing was ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.014161

    authors: Santiago-Sim T,Fang X,Hennessy ML,Nalbach SV,DePalma SR,Lee MS,Greenway SC,McDonough B,Hergenroeder GW,Patek KJ,Colosimo SM,Qualmann KJ,Hagan JP,Milewicz DM,MacRae CA,Dymecki SM,Seidman CE,Seidman JG,Kim DH

    更新日期:2016-12-01 00:00:00

  • Epidemiology and costs of acute hospital care for cerebrovascular disease in diabetic and nondiabetic populations.

    abstract:BACKGROUND AND PURPOSE:Little is known about the pattern of cerebrovascular disease (CVD) for diabetic and nondiabetic patients or about the cost of treatment for CVD in the United Kingdom. The purpose of this study was to extend previous work to describe the epidemiology and cost of acute care of CVD as a frequent com...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.28.6.1142

    authors: Currie CJ,Morgan CL,Gill L,Stott NC,Peters JR

    更新日期:1997-06-01 00:00:00

  • Seasonal variation in stroke incidence in Hisayama, Japan.

    abstract::We investigated seasonal variation in the incidence of cerebral stroke among the general population aged greater than or equal to 40 years in November of 1961 in Hisayama, Japan. During the 24-year follow-up period, 311 cases of cerebrovascular diseases occurred. The date or month of onset was determined in 308 cases,...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.21.9.1262

    authors: Shinkawa A,Ueda K,Hasuo Y,Kiyohara Y,Fujishima M

    更新日期:1990-09-01 00:00:00

  • Neuroprotective effects of leptin against ischemic injury induced by oxygen-glucose deprivation and transient cerebral ischemia.

    abstract:BACKGROUND AND PURPOSE:Leptin is the major adipose hormone that regulates body weight and energy expenditure by activating leptin receptors in the hypothalamus. Leptin receptors are also present in other cell types, and a potent antiapoptotic effect for leptin has recently been reported. We investigated whether leptin ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.482786

    authors: Zhang F,Wang S,Signore AP,Chen J

    更新日期:2007-08-01 00:00:00

  • Low carotid calcium score is associated with higher levels of glycosaminoglycans, tumor necrosis factor-alpha, and parathyroid hormone in human carotid plaques.

    abstract:BACKGROUND AND PURPOSE:Computed tomography (CT) is used to study coronary artery plaques, but little is known about its potential to characterize plaque composition. This study assesses the relation between carotid calcium score (CCS) by CT and plaque composition, namely extracellular matrix, inflammatory mediators, an...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.111.620658

    authors: Edsfeldt A,Dias N,Elmståhl B,Müller MF,Berg K,Nitulescu M,Persson A,Ekberg O,Gonçalves I

    更新日期:2011-10-01 00:00:00

  • Mismatch Profile Influences Outcome After Mechanical Thrombectomy.

    abstract:BACKGROUND AND PURPOSE:Mechanical thrombectomy (MT) is the recommended treatment for acute ischemic stroke caused by anterior circulation large vessel occlusion. However, despite a high rate of reperfusion, the clinical response to successful MT remains highly variable in the early time window where optimal imaging sel...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.120.031929

    authors: Olivot JM,Albucher JF,Guenego A,Thalamas C,Mlynash M,Rousseau V,Drif A,Christensen S,Sommet A,Viguier A,Darcourt J,Calvière L,Menegon P,Raposo N,Januel AC,Bonneville F,Tourdias T,Mazighi M,Sibon I,Albers GW,Cognar

    更新日期:2021-01-01 00:00:00

  • Cerebral hypoperfusion during acute Kawasaki disease.

    abstract:BACKGROUND AND PURPOSE:Kawasaki disease is a febrile disease of children notable for systemic vasculitis. There have been many previous reports of various complications, including disorders of the central nervous system. We evaluated cerebral perfusion during the acute stage in patients with Kawasaki disease. METHODS:...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.29.7.1320

    authors: Ichiyama T,Nishikawa M,Hayashi T,Koga M,Tashiro N,Furukawa S

    更新日期:1998-07-01 00:00:00

  • Immediate changes in stroke lesion volumes post thrombolysis predict clinical outcome.

    abstract:BACKGROUND AND PURPOSE:We hypothesize that reversal in diffusion-weighted imaging (DWI) volume at 24 hours predicts favorable clinical outcome only if accompanied by immediate reperfusion. Our aim was to quantify the immediate DWI and mean transit time changes at 2 and 24 hours after intravenous tissue-type plasminogen...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.114.006082

    authors: Luby M,Warach SJ,Nadareishvili Z,Merino JG

    更新日期:2014-11-01 00:00:00

  • Safety, feasibility, and short-term follow-up of drug-eluting stent placement in the intracranial and extracranial circulation.

    abstract:BACKGROUND AND PURPOSE:The use of bare metal stents to treat symptomatic intracranial stenosis may be associated with significant restenosis rates. The advent of drug-eluting stents (DESs) in the coronary circulation has resulted in a reduction of restenosis rates. We report our technical success rate and short-term re...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/01.STR.0000242481.38262.7b

    authors: Gupta R,Al-Ali F,Thomas AJ,Horowitz MB,Barrow T,Vora NA,Uchino K,Hammer MD,Wechsler LR,Jovin TG

    更新日期:2006-10-01 00:00:00

  • Factors influencing the frequency of fluorescence transients as markers of peri-infarct depolarizations in focal cerebral ischemia.

    abstract:BACKGROUND AND PURPOSE:Peri-infarct depolarizations (PIDs) that occur in ischemic boundary zones of the cerebral cortex of experimental animals have been shown to promote rather than simply to indicate the evolution of the lesion and are especially prominent in the rat. To study the influence of one factor, species, on...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.31.1.214

    authors: Strong AJ,Smith SE,Whittington DJ,Meldrum BS,Parsons AA,Krupinski J,Hunter AJ,Patel S,Robertson C

    更新日期:2000-01-01 00:00:00

  • Risk of thromboembolic events in atrial fibrillation with chronic kidney disease.

    abstract:BACKGROUND AND PURPOSE:Chronic kidney disease may increase the risk for ischemic stroke or systemic embolism in patients with nonvalular atrial fibrillation (AF). We conducted a meta-analysis to summarize all published studies to investigate the link between chronic kidney disease and risk of thromboembolic events in A...

    journal_title:Stroke

    pub_type: 杂志文章,meta分析

    doi:10.1161/STROKEAHA.114.006881

    authors: Zeng WT,Sun XT,Tang K,Mei WY,Liu LJ,Xu Q,Cheng YJ

    更新日期:2015-01-01 00:00:00

  • Collateral Recruitment Is Impaired by Cerebral Small Vessel Disease.

    abstract::Background and Purpose- Cerebral small vessel disease (SVD) is associated with increased stroke risk and poor stroke outcomes. We aimed to evaluate whether chronic SVD burden is associated with poor recruitment of collaterals in large-vessel occlusive stroke. Methods- Consecutive patients with middle cerebral artery o...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.119.027661

    authors: Lin MP,Brott TG,Liebeskind DS,Meschia JF,Sam K,Gottesman RF

    更新日期:2020-05-01 00:00:00

  • Increasing rates of dementia at time of declining mortality from stroke.

    abstract:BACKGROUND AND PURPOSE:Stroke is associated with increased risk of dementia. There has been a decline in mortality from stroke among persons 65 and over in recent decades in the US. It is not clear, however, how this process has affected incidence of various dementias. METHODS:We evaluated over time changes in stroke ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000217971.88034.e9

    authors: Ukraintseva S,Sloan F,Arbeev K,Yashin A

    更新日期:2006-05-01 00:00:00

  • Striatal dopamine in acute cerebral ischemia of stroke-resistant rats.

    abstract::We devised the present experiments to assess the effects of ischemia on the production of dopamine in the caudate nucleus of spontaneously hypertensive stroke-resistant rats. Ringer's solution was continuously perfused at a rate of 10 microliters/min through 0.2-mm-diameter dialysis tubing implanted in the rat's cauda...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.19.12.1540

    authors: Kawano T,Tsutsumi K,Miyake H,Mori K

    更新日期:1988-12-01 00:00:00

  • Comparison of six depression rating scales in geriatric stroke patients.

    abstract::We compared three self-rating scales (the Geriatric Depression Scale, the Zung Scale, and the Center for Epidemiologic Studies Depression Scale) with three examiner-rating scales (the Hamilton Rating Scale, the Comprehensive Psychopathological Rating Scale-Depression, and the Cornell Scale), to see which was best for ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.20.9.1190

    authors: Agrell B,Dehlin O

    更新日期:1989-09-01 00:00:00

  • Cerebroprotective effect of lamotrigine after focal ischemia in rats.

    abstract:BACKGROUND AND PURPOSE:Glutamate receptor antagonists are protective in animal models of focal cerebral ischemia. Lamotrigine (3,5-diamino-6-[2,3-dichlorophenyl]-1,2,4-triazine) is an anticonvulsant drug that blocks voltage-gated sodium channels and inhibits the ischemia-induced release of glutamate. We describe the ce...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.26.1.117

    authors: Smith SE,Meldrum BS

    更新日期:1995-01-01 00:00:00

  • Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging.

    abstract:BACKGROUND AND PURPOSE:Angiotensin II produces oxidative stress and endothelial dysfunction in cerebral arteries, and angiotensin II type I receptors may play a role in longevity and vascular aging. Angiotensin-converting enzyme type 2 (ACE2) converts angiotensin II to angiotensin (1-7) and thus, may protect against ef...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.112.667063

    authors: Peña Silva RA,Chu Y,Miller JD,Mitchell IJ,Penninger JM,Faraci FM,Heistad DD

    更新日期:2012-12-01 00:00:00

  • Regression of carotid stenoses after corticosteroid therapy in occlusive thromboaortopathy (Takayasu's disease).

    abstract::A 34-year-old, single Japanese woman with active Takayasu's disease presented with stenosed bilateral common carotid arteries, subtotal occlusion of the left subclavian artery, and complete occlusion of the ipsilateral proximal vertebral artery, as demonstrated by angiography. A right subclavian-left vertebral bypass ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.18.3.677

    authors: Ishikawa K,Yonekawa Y

    更新日期:1987-05-01 00:00:00

  • Long-term angiographic recurrences after selective endovascular treatment of aneurysms with detachable coils.

    abstract:BACKGROUND AND PURPOSE:Our aim in this study was to assess the incidence and determining factors of angiographic recurrences after endovascular treatment of aneurysms. METHODS:A retrospective analysis of all patients with selective endosaccular coil occlusion of intracranial aneurysms prospectively collected from 1992...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000073841.88563.E9

    authors: Raymond J,Guilbert F,Weill A,Georganos SA,Juravsky L,Lambert A,Lamoureux J,Chagnon M,Roy D

    更新日期:2003-06-01 00:00:00

  • Relationship between white-matter hyperintensities and hematoma volume and growth in patients with intracerebral hemorrhage.

    abstract:BACKGROUND AND PURPOSE:The presence of white-matter hyperintensities (WMHs) has been linked to intracerebral hemorrhage (ICH). We sought to determine whether the severity of WMHs influences hematoma growth and ICH volume. METHODS:We retrospectively reviewed prospectively collected clinical, laboratory, and radiologic ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.109.564955

    authors: Lou M,Al-Hazzani A,Goddeau RP Jr,Novak V,Selim M

    更新日期:2010-01-01 00:00:00

  • Postischemic production of eicosanoids in gerbil brain.

    abstract::The postischemic production of PGE2, PGD2, 6-keto-PGF1 alpha, and TXB2 in brain tissue was studied in Mongolian gerbils using tissue extraction as well as a new ex vivo method. This new method permits the study of prostaglandin synthesis in slices from discrete areas of the brain (cortex, hippocampus, striatum, hypoth...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.18.1.111

    authors: Kempski O,Shohami E,von Lubitz D,Hallenbeck JM,Feuerstein G

    更新日期:1987-01-01 00:00:00