Abstract:
BACKGROUND AND PURPOSE:Elevated plasma homocysteine level has been associated with increased risk for cardiovascular and cerebrovascular disease. Variation in the levels of this amino acid has been shown to be due to nutritional status and methylenetetrahydrofolate reductase (MTHFR) genotype. METHODS:Under a case-control design we compared fasting levels of homocysteine and MTHFR genotypes in groups of subjects consisting of stroke, vascular dementia (VaD), and Alzheimer disease patients and normal controls from Northern Ireland. RESULTS:A significant increase in plasma homocysteine was observed in all 3 disease groups compared with controls. This remained significant after allowance for confounding factors (age, sex, hypertension, cholesterol, smoking, creatinine, and nutritional measures). MTHFR genotype was not found to influence homocysteine levels, although the T allele was found to increase risk for VaD and perhaps dementia after stroke. CONCLUSIONS:We report that moderately high plasma levels of homocysteine are associated with stroke, VaD, and Alzheimer disease. This is not due to vascular risk factors, nutritional status, or MTHFR genotype.
journal_name
Strokejournal_title
Strokeauthors
McIlroy SP,Dynan KB,Lawson JT,Patterson CC,Passmore APdoi
10.1161/01.str.0000032550.90046.38subject
Has Abstractpub_date
2002-10-01 00:00:00pages
2351-6issue
10eissn
0039-2499issn
1524-4628journal_volume
33pub_type
杂志文章相关文献
STROKE文献大全abstract::The effect of respiration on the cerebrovascular response to elevated intracranial pressure (ICP) was studied in anesthetized dogs. Total and regional cerebral blood flows were measured using labelled microspheres. In spontaneously breathing dogs total and regional cerebral blood flows increased when cerebral perfusio...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.8.2.243
更新日期:1977-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:MRI characterization of carotid plaque has been studied recently as a potential tool to predict stroke caused by carotid atherosclerosis. We performed a systematic review and meta-analysis to summarize the association of MRI-determined intraplaque hemorrhage, lipid-rich necrotic core, and thinnin...
journal_title:Stroke
pub_type: 杂志文章,meta分析,评审
doi:10.1161/STROKEAHA.113.002551
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We studied the relationship between cigarette smoking and stroke incidence and mortality in the Chinese adult population. METHODS:We conducted a prospective cohort study in a nationally representative sample of 169 871 Chinese men and women aged 40 years and older. Data on cigarette smoking and ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.505305
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Warfarin reduces stroke risk by approximately 60% in patients with atrial fibrillation (AF). Differences in awareness and treatment of AF may contribute to racial and geographic disparities in stroke mortality. The objective was to examine predictors of awareness of the diagnosis of AF and treatm...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.109.573907
更新日期:2010-04-01 00:00:00
abstract::We tested the hypothesis that hypertension is more common and cardiac embolism less common in patients with lacunar infarction than in patients with other types of cerebral infarction. We studied risk factor profiles in a series of 102 consecutive patients with a lacunar infarct and 202 consecutive patients with a car...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.21.3.375
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Studies on cardiovascular disease have preferentially involved men because of the lower frequency of the disease in preelderly women. The aim of this analysis was to examine, with the use of a standardized ultrasound protocol, a cohort of women to differentiate early atherosclerotic lesions in di...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/hs0901.095601
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Exogenously administered fructose-1,6-bisphosphate reduces neuronal injury from hypoxic or ischemic brain insults. To test the hypothesis that fructose-1,6-bisphosphate prevents changes in intracellular calcium ([Ca2+]i) and high-energy phosphate levels, we measured [Ca2+]i, intracellular pH (pHi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.11.1617
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Body mass index has been associated with ischemic stroke in older populations, but its association with stroke in younger populations is not known. In light of the current obesity epidemic in the United States, the potential impact of obesity on stroke risk in young adults deserves attention. ME...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/STROKEAHA.115.008940
更新日期:2015-06-01 00:00:00
abstract::Coarctation of the aorta is an uncommon cause of cerebral hemorrhage in the full- or near-term infant. The clinical, radiologic, and neurologic findings of four infants with aortic coarctation and cerebral hemorrhage are presented. In all four infants, cerebral hemorrhage was associated with only moderate elevation of...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.13.4.491
更新日期:1982-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Chinese patients largely experience acute ischemic stroke (AIS) because of large artery atherosclerosis rather than cardioembolism, and whether tirofiban is safe and effective in these patients treated with endovascular thrombectomy (ET) is unknown. This study evaluated the safety and efficacy of...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.117.019193
更新日期:2017-12-01 00:00:00
abstract::In a postasphyxia neonatal lamb model, the responses of the cerebral circulation to hypoxic hypoxia and changes in systemic arterial blood pressure were examined. Ventilated newborn lambs (n = 14) were subjected to a gradual asphyxial insult, resuscitated, and returned to control ventilator settings. During the time 2...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.19.2.239
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Disturbed cerebral autoregulation has been reported to correlate with an unfavorable outcome after head injury. Using transcranial Doppler ultrasonography, we investigated whether hemodynamic responses to spontaneous variations of cerebral perfusion pressure (CPP) provide reliable information on ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.10.1829
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Results from large multicenter studies have shown that carotid endarterectomy, performed with low perioperative morbidity and mortality, is beneficial for patients with symptomatic carotid stenosis > or = 70% as calculated according to strict angiographic criteria. To apply these results in clini...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.8.1325
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Neuroradiological characteristics and functional outcomes of patients with intracerebral hemorrhage (ICH) during novel oral anticoagulant treatment were not well defined. We examined these in comparison with those during warfarin treatment. METHODS:The consecutive 585 patients with ICH admitted ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.006661
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:This study aimed to identify aspects of the caregiving situation contributing to family caregivers' psychological well-being. METHODS:Longitudinal cohort study with structured quantitative interviews 1, 3, 6, and 12 months post stroke. A subset of participants also completed surveys 18 and 24 mo...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.113.004309
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Follow-up imaging is often performed in intracranial aneurysms that are not treated. We performed a systematic review and meta-analysis on patient- and aneurysm-specific risk factors for aneurysm growth. METHODS:We searched EMBASE and MEDLINE for cohort studies describing risk factors for aneury...
journal_title:Stroke
pub_type: 杂志文章,meta分析,评审
doi:10.1161/STROKEAHA.115.012162
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Limited data are available on management of outpatients with stroke or transient ischemic attack (TIA) and on clinicians' reasons for withholding procedures recommended by guidelines. We assessed to what extent guidelines are appropriately applied after ischemic stroke or TIA, in admitted patient...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/01.STR.0000226463.17988.a3
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Reduced arterial distensibility has been introduced as a novel risk factor for atherosclerosis. The importance of the genetic contribution to variation in distensibility is largely unknown. The purpose of this study was to estimate heritability of carotid distensibility. METHODS:The ongoing Nort...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000185926.05011.72
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Previous studies have evaluated the association of body mass index (BMI) with the risk of all-cause and cardiovascular disease mortality among diabetic patients, and results were controversial. No studies have focused on the association between BMI and stroke risk among diabetic patients. We aime...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.006718
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Studies of the cerebroprotective effects of selective brain cooling have failed to show amelioration of ischemic injury in the cerebral cortex. This study was designed to test the hypothesis that mild-to-moderate selective brain cooling initiated after the onset of global brain ischemia in rats p...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.12.1792
更新日期:1992-12-01 00:00:00
abstract:UNLABELLED:The pathophysiology of postischemic encephalopathy is complex, and includes tissue acidosis, edema, hypoperfusion, membrane dysfunction, impaired energy production, and possibly hypermetabolism. We tested the hypothesis that this multifactorial clinical problem must be approached with multifaceted therapy, w...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.15.5.803
更新日期:1984-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The primary purpose of intracranial aneurysm treatment is to prevent rupture. Risk factors for rupture after aneurysm treatment have not been clearly established, and the need to completely occlude aneurysms is debated. METHODS:The Cerebral Aneurysm Rerupture After Treatment (CARAT) study is an ...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.107.495747
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Stroke patients are heterogeneous not only with respect to etiology but also in terms of preexisting clinical conditions. Approximately one fifth of patients with acute stroke are hyperglycemic and/or have had a recent infectious or inflammatory condition. Summary of Review-- Experimental research indicates ...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/hs1001.096588
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Apraxia of speech (AOS) is a motor speech disorder, which is clinically characterized by the combination of phonemic segmental changes and articulatory distortions. AOS has been believed to arise from impairment in motor speech planning/programming and differentiated from both aphasia and dysarth...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.115.010402
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Following our treatment of a patient with hypoglycemia-induced brain stem symptoms, we examined the possible mechanisms for hypoglycemia presenting as basilar artery disease. CASE DESCRIPTION:We describe a patient who had progressive brain stem symptoms due to a diet-induced hypoglycemia initial...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.1.112
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Data on long-term outcome after intravenous tissue-type plasminogen activator (tPA) in ischemic stroke are limited. We examined the risk of long-term mortality, recurrent ischemic stroke, and major bleeding, including intracranial and gastrointestinal bleeding, in intravenous tPA-treated patients...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.006570
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It is important to know the costs of hospitalization for patients undergoing endovascular embolectomy so that comparisons can be made with payments to hospitals. METHODS:Using the National Inpatient Sample, we evaluated the costs of hospitalization for patients treated with endovascular embolect...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.618405
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Futile recanalization after acute ischemic stroke occurs in almost half of the patients despite optimal angiographic results. Multimodal neuroimaging may help to improve patient's selection but is still dismissed by many interventionalists. Our aim was to evaluate the accuracy of each parameter o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.114.008598
更新日期:2015-09-01 00:00:00
abstract::Regional cerebral blood flow (CBF) was measured (intra-arterial injections of 133Xe) and electroencephalograms (EEG) were recorded periodically before, for two hours during, and for one and one-fourth hours after middle cerebral artery (MCA) occlusion in 20 squirrel monkeys (Saimiri sciureus). A CBF-Paco2 response cur...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.6.2.121
更新日期:1975-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Transcranial color-coded duplex sonography (TCCS) enables visualization of the intracranial parenchymal structures and measurement of blood flow velocity in the basal cerebral arteries. The present study aims to evaluate prospectively the clinical usefulness of TCCS in patients with acute stroke....
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.26.11.2061
更新日期:1995-11-01 00:00:00