Abstract:
INTRODUCTION:Bleeding is increasingly considered an important end point in clinical platelet transfusion studies. Accurate recording and adjudication into well-defined bleeding grades, however, remains a major challenge. METHODS:We developed a computer algorithm for automatic adjudication. The algorithm's results were compared to those of three independent adjudicators. RESULTS:For one of 1186 bleeding days, the clinical report form (CRF) was filled out incorrectly, and the algorithm therefore missed one grade-1 skin bleed. For two bleeding days, the adjudicators incorrectly classified a grade-2 skin bleed as grade-1 while the algorithm correctly classified these days. The algorithm saved approximately six person-hours of adjudication time for the adjudication of 1186 days from 60 patients. DISCUSSION:The algorithm can be an invaluable tool for adjudicating large amounts of bleeding data.
journal_name
Vox Sangjournal_title
Vox sanguinisauthors
Middelburg RA,Ypma PF,van der Meer PF,van Wordragen-Vlaswinkel RJ,Eissen O,Kerkhoffs JLdoi
10.1111/vox.12030subject
Has Abstractpub_date
2013-08-01 00:00:00pages
144-9issue
2eissn
0042-9007issn
1423-0410journal_volume
105pub_type
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