Abstract:
OBJECTIVE:We examined the incidence of mild cognitive impairment (MCI) and its potential vascular risk factors in a prospective population-based study. METHODS:An age-stratified random population-based cohort (baseline n = 1,982), followed for up to 4 years, was annually assessed for cognitive and everyday functioning. Incidence rates were calculated for both cognitive (neuropsychological [NP]-MCI) and functional (Clinical Dementia Rating [CDR] = 0.5) definitions of MCI. Several measures of vascular, metabolic, and inflammatory risk were assessed at baseline. Risk factor analyses used interval censoring survival models, followed by joint modeling of both MCI and attrition due to mortality and illness. RESULTS:Incidence rates for NP-MCI and CDR = 0.5 were 95 and 55 per 1,000 person-years. In individual joint models, risk factors for NP-MCI were diabetes and adiposity (waist: hip ratio), while APOE ε4 genotype and heart failure increased risk of attrition. Adiposity, stroke, heart failure, and diabetes were risk factors for nonamnestic MCI. For CDR = 0.5, risk factors were stroke and heart failure; heart failure and adiposity increased risk of attrition. In multivariable joint models combining all risk factors, adiposity increased risk of NP-MCI, while stroke and heart failure increased risk for CDR = 0.5. Current alcohol use appeared protective against all subtypes. CONCLUSION:Incidence of MCI increased with age regardless of definition and did not vary by sex or education. Several vascular risk factors elevated the risk of incident MCI, whether defined cognitively or functionally, but most were associated with nonamnestic MCI and CDR = 0.5. Controlling vascular risk may potentially reduce risk of MCI.
journal_name
Neurologyjournal_title
Neurologyauthors
Ganguli M,Fu B,Snitz BE,Hughes TF,Chang CCdoi
10.1212/WNL.0b013e318295d776subject
Has Abstractpub_date
2013-06-04 00:00:00pages
2112-20issue
23eissn
0028-3878issn
1526-632Xpii
WNL.0b013e318295d776journal_volume
80pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:BACKGROUND:Clostridium botulinum neurotoxin types A, B, and E cause most cases of the paralytic disease botulism. Little is known about the epidemiology, clinical features, or microbiology of botulism type F. METHODS:Cases of adult type F botulism were identified by review of data collected by CDC's National Botulism ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000187127.92446.4c
更新日期:2005-12-13 00:00:00
abstract::A 38-year-old man from southeastern Connecticut developed a diffuse encephalopathy with partial complex seizures, followed weeks later by arthritis, cryoglobulinemia, and increased serum IgM. CT showed confluent low-density lesions in the deep cerebral white matter consistent with demyelination. Neither the encephalop...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.2.267
更新日期:1985-02-01 00:00:00
abstract:OBJECTIVE:To investigate the pathogenesis of proximal diabetic neuropathy (PDN) with nerve and muscle biopsies. BACKGROUND:Recent evidence suggests that nerve ischemia secondary to immune-mediated vasculopathy rather than diabetic microangiopathy may be responsible for PDN. METHOD:- Fifteen patients with PDN and two ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.1.83
更新日期:2000-07-12 00:00:00
abstract:OBJECTIVE:Utilization of postacute care is associated with improved poststroke outcomes. However, more than 20% of American adults under age 65 are uninsured. We sought to determine whether insurance status is associated with utilization and intensity of institutional postacute care among working age stroke survivors. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182563bf5
更新日期:2012-05-15 00:00:00
abstract::The authors describe two novel mutations of the acid alpha-glucosidase gene, P361L and R437C, which define the juvenile-onset glycogen storage disease type II (GSDII) in a 16-year-old Chinese patient. The asymptomatic 13-year-old brother of the proband is also a compound heterozygote of the two mutations. These result...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000048661.95327.bf
更新日期:2003-02-25 00:00:00
abstract::Gamma hydroxybutyrate was administered to adult cats by intravenous infusion at varying dosages while an electroencephalogram (EEG) was recorded from electrodes placed stereotactically in the right and left hippocampus and thalamic intralaminar nucleus and from cortical electrodes. Blood cerebrospinal fluid samples we...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.1.51
更新日期:1976-01-01 00:00:00
abstract:OBJECTIVES:To determine whether TMEM106B single nucleotide polymorphisms (SNPs) are associated with frontotemporal lobar degeneration (FTLD) in patients with and without mutations in progranulin (GRN) and to determine whether TMEM106B modulates GRN expression. METHODS:We performed a case-control study of 3 SNPs in TME...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31820a0e3b
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Cerebral infarctions are common in older persons but their relationship with dementia and cognitive function remains controversial. METHODS:Participants were 164 older Catholic nuns, priests, and brothers who underwent annual clinical evaluation and brain autopsy at death. The authors quantified number and ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000055863.87435.b2
更新日期:2003-04-08 00:00:00
abstract::We have studied one family of a pedigree in which bulbospinal muscular atrophy and protanopia were segregated. Genotypes for these disorders were obtained on three generations, and the maximum likelihood estimate of recombination fraction was 0.4 with the lod score method. The results indicated that the two loci are n...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.6.1019
更新日期:1987-06-01 00:00:00
abstract::We report a family with Machado-Joseph disease (MJD) that was previously diagnosed with dentatorubral-pallidoluysian atrophy (DRPLA), on the basis of the neuropathologic findings. Because the clinical and pathologic reevaluation strongly suggested a diagnosis of MJD, we conducted a genetic study in the family. Two pat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.4.1154
更新日期:1996-04-01 00:00:00
abstract::Dr. Masur and colleagues(1) from the Childhood Absence Epilepsy Study Group tried to answer a few important questions regarding childhood absence epilepsy (CAE) in their article "Pretreatment cognitive deficits and treatment effects on attention in childhood absence epilepsy." First, they wanted to know whether childr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000436060.67147.25
更新日期:2013-10-29 00:00:00
abstract::Subsequent to publication of the NINDS t-PA Stroke Study results, we sought to determine the proportion of patients eligible for and receiving intravenous tissue plasminogen activator (t-PA) at an active acute stroke treatment center. Over a 12-month period there were 185 stroke code activations. Of these, 134 involve...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.2.501
更新日期:1998-02-01 00:00:00
abstract::We evaluated cognitive outcome in a group of 37 patients who had undergone surgery for rupture and repair of a single intracranial aneurysm at least 6 months previously. We compared outcome--assessed by tests of intelligence, attention, executive functions sensitive to frontal lobe lesions, memory, neglect, and mood, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.5.876
更新日期:1995-05-01 00:00:00
abstract::A cross-sectional survey and subsequent longitudinal study among diabetic residents of Rochester, MN--The Rochester Diabetic Neuropathy Study (RDNS)--is population-based and uses quantitative, validated, and unique end points to detect, classify, and stage neuropathy. Nondiabetic persons, drawn from the same populatio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.6.799
更新日期:1991-06-01 00:00:00
abstract::In patients with cranial dystonia, we compared the effects of central anticholinergic, peripheral anticholinergic, and placebo treatments in a double-blind crossover study. One of the nine patients who completed the study improved markedly with central anticholinergic therapy. The three treatments were indistinguishab...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.34.2.215
更新日期:1984-02-01 00:00:00
abstract::A marked decrease in the amplitude of the evoked thenar compound muscle action potential followed brief exercise at room temperature in two patients with paramyotonia congenita. This decline was more rapid and pronounced in our patient with coexistent thyrotoxicosis. The prolonged recovery period in paramyotonia conge...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.1.130
更新日期:1986-01-01 00:00:00
abstract::Three patients with postanoxic intention myoclonus, two patients with intention tremor, and one patient with cerebral palsy were administered L-5-hydroxytryptophan (L-5HTP), the precursor of serotonin, in combination with MK 486, a peripheral amino acid decarboxylase inhibitor. L-5HTP combined with MK 486 were potent ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.2.135
更新日期:1975-02-01 00:00:00
abstract::We reviewed the outcome (developmental, neurologic, and seizure) and prognostic factors of 57 cases of infantile spasms (17 cryptogenic, 40 symptomatic). The mean developmental score of the cryptogenic group (71.2 +/- 24.2) was significantly higher than that of the symptomatic group (48.4 +/- 24.5), as assessed by the...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.11.2322
更新日期:1993-11-01 00:00:00
abstract:OBJECTIVE:We performed propensity score (PS) models to compare the outcome of patients with myasthenia gravis (MG) submitted to 2 different surgical approaches: extended transsternal (T-3b) or thoracoscopic extended thymectomy (VATET). METHODS:Patients' clinical data were retrieved from the MG database of the C. Besta...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004082
更新日期:2017-07-11 00:00:00
abstract::Many aging-associated neurologic disorders, including primary malignant brain tumors (MBT), share a common biphasic age-specific mortality rate pattern: initially increasing exponentially with age, and then declining. A modeling study using MBT mortality was conducted to determine if the observed biphasic pattern of M...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.55.6.750
更新日期:2000-09-26 00:00:00
abstract::Coenzyme Q10 (CoQ10) transfers electrons from complexes I and II of the mitochondrial respiratory chain to complex III. There is one published report of human CoQ10 deficiency describing two sisters with encephalopathy, proximal weakness, myoglobinuria, and lactic acidosis. We report a patient who had delayed motor mi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.5.1238
更新日期:1997-05-01 00:00:00
abstract::We describe a case of West Nile virus (WNV) infection in an HIV-infected patient who presented with an isolated flaccid monoparesis of the right upper extremity. To our knowledge, this is the first reported case of flaccid paralysis caused by WNV infection in an HIV-infected patient. We then review the medical literat...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000253223.07720.bb
更新日期:2007-02-13 00:00:00
abstract:OBJECTIVE:To explore an association with survival of modifying the current standard of care for patients with newly diagnosed glioblastoma of surgery followed by radiotherapy plus concurrent and 6 cycles of maintenance temozolomide chemotherapy (TMZ/RT → TMZ) by extending TMZ beyond 6 cycles. METHODS:The German Glioma...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000003809
更新日期:2017-04-11 00:00:00
abstract:BACKGROUND:Paroxysmal nonkinesigenic dyskinesia (PNKD) is a rare disorder characterized by episodic hyperkinetic movement attacks. We have recently identified mutations in the MR-1 gene causing familial PNKD. METHODS:We reviewed the clinical features of 14 kindreds with familial dyskinesia that was not clearly induced...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000262029.91552.e0
更新日期:2007-05-22 00:00:00
abstract::Nine neurosurgical patients suffering from a variety of brain tumors were studied. Sodium valproate was given for 3 days before surgery. At craniotomy, sections of brain and samples of cerebrospinal fluid (CSF) and plasma were obtained and assayed for sodium valproate concentrations. Brain levels were 6.8 to 27.9% of ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.4.486
更新日期:1981-04-01 00:00:00
abstract:OBJECTIVE:To determine the contribution of sequence variations in PHOX2B to sudden unexpected death in epilepsy (SUDEP). METHODS:Patients who died of SUDEP were identified in 2 major Australian cohorts, the Epilepsy Genetics research program in Melbourne and postmortem cases at the Department of Forensic Medicine in S...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000000781
更新日期:2014-09-09 00:00:00
abstract:OBJECTIVE:We aimed to investigate whether cognitive deficits and structural and functional connectivity changes can be detected before symptom onset in a large cohort of carriers of microtubule-associated protein tau and progranulin mutations. METHODS:In this case-control study, 75 healthy individuals (aged 20-70 year...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31828407bc
更新日期:2013-02-26 00:00:00
abstract:BACKGROUND:Bilateral absent N20 responses of median nerve somatosensory evoked potentials (SEPs) reliably predict poor prognosis after cardiac arrest. However, the studies supporting this fact were carried out before hypothermia was established as standard treatment. Recent evidence suggests that hypothermia treatment ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181d5a631
更新日期:2010-03-23 00:00:00
abstract::We compared MRI and CT in a study of 175 patients; 87 infarcts within a week, 40 from 1 to 40 weeks, 25 a year after onset, and 23 hemorrhages, 18 within 2 weeks and 5 in 4 to 8 weeks. Fifty-nine infarcts and eight hemorrhages had sequential scanning. MRI is more sensitive than CT in the early detection of cerebral in...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.10.1580
更新日期:1987-10-01 00:00:00
abstract:OBJECTIVES:Using high-resolution structural MRI, we endeavored to study the relationships among APOE ε4, hippocampal subfield and stratal anatomy, and episodic memory. METHODS:Using a cross-sectional design, we studied 11 patients with Alzheimer disease dementia, 14 patients with amnestic mild cognitive impairment, an...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000154
更新日期:2014-02-25 00:00:00