Abstract:
:Subsequent to publication of the NINDS t-PA Stroke Study results, we sought to determine the proportion of patients eligible for and receiving intravenous tissue plasminogen activator (t-PA) at an active acute stroke treatment center. Over a 12-month period there were 185 stroke code activations. Of these, 134 involved patients with ischemic stroke, and 48 of these (36%) were potentially eligible for treatment with t-PA by the time criterion (i.e., interval from stroke onset to hospital presentation < 3 hours). Nine of the 48 potentially eligible patients (19%) and 9 of 134 ischemic stroke patients (7%) overall received t-PA. In our patient population only a small proportion of all patients with acute ischemic stroke presently are eligible for treatment with t-PA.
journal_name
Neurologyjournal_title
Neurologyauthors
Zweifler RM,Brody ML,Graves GC,U TT,Drinkard R,Cunningham S,Rothrock JFdoi
10.1212/wnl.50.2.501subject
Has Abstractpub_date
1998-02-01 00:00:00pages
501-3issue
2eissn
0028-3878issn
1526-632Xjournal_volume
50pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::Fasciculations and cramps may occur in motor neuron disease or as part of a more benign syndrome. A man with apparently benign fasciculations and cramps for 4 years developed progressive muscle weakness and wasting. Such a previously undocumented evolution of benign fasciculations and cramps to motor neuron disease ma...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.7.997
更新日期:1986-07-01 00:00:00
abstract::The prevalence and psychopathologic features of psychiatric adverse events (PAE) in 517 patients taking levetiracetam (LEV) were investigated. Fifty-three (10.1%) patients developed PAE. A significant association was found with previous psychiatric history, history of febrile convulsions, and history of status epilept...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000078031.32904.0d
更新日期:2003-09-09 00:00:00
abstract:OBJECTIVE:To determine if abnormalities exist in postural control in autism and if they are related to age. METHODS:Dynamic posturography was performed in 79 autistic individuals without mental retardation and 61 healthy volunteers between ages 5 and 52 years. Both the sensory organization and the movement coordinatio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000145771.98657.62
更新日期:2004-12-14 00:00:00
abstract::A 12-year-old girl who had zoster ophthalmicus 10 months earlier presented with hemiparesis and corresponding basal ganglionic infarction related to middle cerebral artery branch thrombosis ipsilateral to the zoster. Hematologic evaluation disclosed protein C deficiency. This represents the first zoster-associated str...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.5.1128
更新日期:1999-09-22 00:00:00
abstract:OBJECTIVE:To determine the efficacy and tolerability of unilateral thalamic deep brain stimulation (DBS) for patients with medically refractory essential tremor (ET) and the tremor associated with Parkinson's disease (PD). BACKGROUND:The tremor of ET and PD may produce functional disability despite optimal medical the...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.51.4.1063
更新日期:1998-10-01 00:00:00
abstract::A 14-year-old boy with exercise-related myalgia and cramps had several episodes of myoglobinuria since early childhood. An episode at 2 years of age caused acute renal failure. Histochemical and biochemical analysis of muscle showed a combined defect of phosphofructokinase (PFK) and adenosine monophosphate (AMP) deami...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.1.296
更新日期:1998-01-01 00:00:00
abstract::This is a report on hepatic adverse events associated with dantrolene therapy. All cases reported to the manufacturer are included, from all sources, through 1987. Of 122 cases containing sufficient data to analyze, 47 patients had asymptomatic transaminase elevations, 12 had additional mild (less than or equal to 2.5...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.9.1427
更新日期:1990-09-01 00:00:00
abstract::A 48-year-old man presented with progressive spastic paraparesis and diffuse white matter involvement on neuroimaging that suggested a primary demyelinating disease. Brain biopsy 3 years after onset of symptoms demonstrated idiopathic granulomatous angiitis. In patients with MRI features of diffuse white matter diseas...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.6.1696
更新日期:1997-12-01 00:00:00
abstract::The visual-motor adaptation to lateral displacement of vision by prism glasses was studied in normal individuals and patients with cerebellar dysfunction, Parkinson's disease, right or left cerebral hemisphere lesions, Alzheimer's disease, or Korsakoff's syndrome. Adaptation was analyzed in two phases, the return to n...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.6.766
更新日期:1983-06-01 00:00:00
abstract::Studies of automobile accident frequency among drivers with AD have yielded conflicting results about the risk of accidents. To develop a practice parameter regarding driving and AD the authors performed a systematic review of the literature. The authors identified well-designed, controlled studies of driving and AD u...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.54.12.2205
更新日期:2000-06-27 00:00:00
abstract::This study was undertaken to determine the amount and histologic appearance of the persistent thymic tissue removed post mortem from 20 patients over 60 years of age with myasthenia gravis. One patient died several days after thymectomy. No recognizable thymic tissue on gross examination was seen in any patient. On mi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.3.294
更新日期:1975-03-01 00:00:00
abstract:OBJECTIVE:To investigate recovery of medical decision-making capacity (MDC) over the first year following traumatic brain injury (TBI). METHODS:A total of 177 participants (111 persons with TBI and 66 healthy controls) were recruited from an inpatient/outpatient TBI rehabilitation unit and outpatient neurology departm...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003079
更新日期:2016-09-06 00:00:00
abstract::We performed a retrospective study to characterize the type, frequency, and timing of neurologic complications in patients with B-cell chronic lymphocytic leukemia (B-CLL). We reviewed 962 total charts with a median follow-up time of 57.5 months. There were 109 cases (11.3%) of neurologic complications, including 69 c...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.2.407
更新日期:1997-02-01 00:00:00
abstract:OBJECTIVE:To describe the detection frequency and clinical associations of immunoglobulin G (IgG) targeting dipeptidyl-peptidase-like protein-6 (DPPX), a regulatory subunit of neuronal Kv4.2 potassium channels. METHODS:Specimens from 20 patients evaluated on a service basis by tissue-based immunofluorescence yielded a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000991
更新日期:2014-11-11 00:00:00
abstract:BACKGROUND:Saccades are essential for optimal visual function. Chiari type II malformation (CII) is a congenital anomaly of the cerebellum and brainstem, associated with spina bifida. OBJECTIVE:To investigate the effects of CII on saccades and correlate saccadic parameters with brain MRI measurements. METHODS:Saccade...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000166034.71337.5E
更新日期:2005-06-28 00:00:00
abstract:OBJECTIVE:We aimed to assess sensitivity and specificity of the updated criteria for behavioral variant frontotemporal dementia (bvFTD) based on a large autopsy-confirmed cohort of patients with dementia. METHODS:Two hundred thirty-nine consecutive pathologically confirmed dementia patients, clinically assessed in a s...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318292a342
更新日期:2013-05-14 00:00:00
abstract::Parent of origin effects caused by genomic imprinting may influence the phenotypic expression of a number of heritable human disorders. To test this phenomenon in Tourette's syndrome (TS), we studied 437 first degree relatives systematically ascertained through 57 probands. We compared age at onset, age at diagnosis, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.4.934
更新日期:1997-04-01 00:00:00
abstract::The motor effects of direct agonists which act selectively on certain dopamine receptors were studied in monkeys rendered hemiparkinsonian by unilateral intracarotid injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The D-2 dopamine agonist, LY 171555, but not the D-1 agonist, SKF 38393, reduced parkin...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.10.1592
更新日期:1987-10-01 00:00:00
abstract::To determine whether the complete correction of hyperglycemia of diabetes can rapidly improve abnormal peripheral nerve function, eight hyperglycemic insulin-requiring diabetics underwent 3 days of glucose control with an artificial endocrine pancreas, the BIOSTATOR Glucose Controller. Comparison of neurologic assessm...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.31.11.1375
更新日期:1981-11-01 00:00:00
abstract:OBJECTIVE:We developed the Recurrence and Recovery Questionnaire (RRQ) by converting the Pediatric Stroke Outcome Measure (PSOM) to a questionnaire for telephone interview and sought to validate the RRQ in a large cohort. METHOD:We analyzed parents' RRQ responses and same-day PSOM assessments for 232 children who had ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318266fc9a
更新日期:2012-08-28 00:00:00
abstract:BACKGROUND:On proton magnetic resonance spectroscopic imaging ((1)H MRSI), there is a decrease in cerebellar N-acetylaspartate/total creatine (NAA/tCr) in essential tremor (ET), signifying cerebellar neuronal dysfunction or degeneration. Harmane, which is present in the human diet, is a potent tremor-producing neurotox...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000266663.27398.9f
更新日期:2007-08-07 00:00:00
abstract::A patient with classic (type A) Niemann-Pick disease had the usual clinical signs of failure to thrive, hepatosplenomegaly, and intellectual deterioration in the first year of life. In addition, there was striking hypotonia, areflexia, and abnormal nerve conduction velocities. Pathologically, the Schwann cells were fi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.2.107
更新日期:1975-02-01 00:00:00
abstract:OBJECTIVE:To characterize brain functional connectivity in subjects with prechiasmatic visual system damage and relate functional connectivity features to extent of vision loss. METHODS:In this case-control study, resting-state, eyes-closed EEG activity was recorded in patients with partial optic nerve damage (n = 15)...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000000672
更新日期:2014-08-05 00:00:00
abstract::Among 50 patients with phenytoin intoxication, 14 had seizures during the episode. Seizures in 9 of these 14 patients probably resulted from poor seizure control despite high phenytoin levels, but in 5 cases, attacks were attributed to phenytoin toxicity. The only factor that seemed to correlate with seizures was a se...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.12.1769
更新日期:1985-12-01 00:00:00
abstract::A 3-year old, previously well child developed paroxysms of left thigh pain. Evaluation was unremarkable except for interictal and postictal EEG epileptiform activity in the right parietal and posterior temporal regions. The painful spells were controlled with anticonvulsant medication. Episodes of paroxysmal, unexplai...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.2.329
更新日期:1988-02-01 00:00:00
abstract::In two patients, a sensory neuronopathy was the initial presentation of Sjögren's syndrome. There was no systemic or peripheral nerve vasculitis. Immunochemical studies failed to demonstrate specific antibodies against the nervous system. These features suggest that the damage to the sensory neurons might not be media...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.10.1637
更新日期:1988-10-01 00:00:00
abstract:OBJECTIVE:To apply the ATN scheme to memory clinic patients, to assess whether it discriminates patient populations with specific features. METHODS:We included 305 memory clinic patients (33% subjective cognitive decline [SCD]: 60 ± 9 years, 61% M; 19% mild cognitive impairment [MCI]: 68 ± 9 years, 68% M; 48% dementia...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008361
更新日期:2019-10-22 00:00:00
abstract::We attempted to determine whether separable components underlie normal subjects' upward bias in bisecting vertical and radial lines under visual guidance. Twelve normal subjects indicated the midpoint of visually presented lines oriented vertically, radially, and horizontally. We placed directional labels ("TOP" and "...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.4.703
更新日期:1994-04-01 00:00:00
abstract:OBJECTIVE:To quantify the associations of peripapillary retinal nerve fiber layer (pRNFL) thickness and macular ganglion cell layer (mGCL) volume with cognitive functioning and to investigate how demographic and vascular health factors affect these associations in a population-based sample of adults. METHODS:The sampl...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000010146
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:To determine the risk, predictors, and prognosis of independence loss and institutionalization in patients with early Parkinson disease (PD). METHODS:We conducted a prospective population-based 5-year longitudinal study following 189 patients with incident PD and 174 controls matched for age, sex, and comorb...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000003213
更新日期:2016-10-11 00:00:00