Abstract:
PURPOSE:Late gadolinium enhancement cardiac MR (LGE-CMR) and extracellular volume fraction (ECV-CMR) are widely used to evaluate macroscopic and microscopic myocardial fibrosis. Macrocyclic contrast media are increasingly used off-label for myocardial scar assessment, given the superior safety profile of these agents. We aimed to assess the performance of two macrocyclic contrast agents, gadoterate meglumine and gadobutrol, for the evaluation of myocardial scar. MATERIAL AND METHODS:Forty subjects (61 ± 11 years, 67.5% men) who underwent LGE-CMR using gadobutrol were prospectively recruited for a research CMR scan using same-dose gadoterate meglumine (0.2 mmol/kg) at 1.5 T. Myocardial scar quantification was performed using a short-axis phase-sensitive inversion recovery (PSIR) Turbo-FLASH and steady-state free precession (SSFP) images. Pre- and post-contrast T1-mapping was employed to assess myocardial ECV. An intraclass correlation coefficient (ICC) was used to check for reliability between the two contrast agents. RESULTS:Using manual thresholding on PSIR Turbo-FLASH images, mean LGE scar percentage (LGE%) was 9.9 ± 9.7% and 9.4 ± 9.7% for gadobutrol and gadoterate meglumine, respectively (p > 0.05) (ICC: 0.99, 95% CI: 0.97-0.99). Using the PSIR SSFP technique and manual thresholding, LGE% averaged 7.5 ± 9.0% and 7.1 ± 8.6% for gadobutrol and gadoterate meglumine, respectively (p > 0.05) (ICC: 0.99, 95% CI: 0.98-0.99). Average ECV with gadobutrol and gadoterate meglumine were similar at 28.40 ± 4.88 and 28.46 ± 4.73 (p > 0.05) with a strong correlation (ICC: 0.98, 95% CI: 0.94-0.99). CONCLUSION:We found LGE- and ECV-CMR values derived from gadoterate meglumine comparable to values derived from gadobutrol. Gadoterate meglumine has a comparable performance to gadobutrol in identifying LGE-derived myocardial scar both qualitatively and quantitatively. KEY POINTS:• Late gadolinium-enhancement cardiac MR (LGE-MR) and extracellular volume (ECV) fraction are widely used to evaluate macroscopic and microscopic myocardial fibrosis. • Macrocyclic contrast media are increasingly used off-label for myocardial scar assessment, given the presumed superior safety profile of these agents. • LGE- and ECV-CMR values derived from gadoterate meglumine are comparable to values derived from gadobutrol.
journal_name
Eur Radioljournal_title
European radiologyauthors
Rahsepar AA,Ghasemiesfe A,Suwa K,Dolan RS,Shehata ML,Korell MJ,Naresh NK,Markl M,Collins JD,Carr JCdoi
10.1007/s00330-018-5956-3subject
Has Abstractpub_date
2019-08-01 00:00:00pages
4357-4367issue
8eissn
0938-7994issn
1432-1084pii
10.1007/s00330-018-5956-3journal_volume
29pub_type
杂志文章abstract::Endovascular treatment options for visceral artery pseudoaneurysms depend on lesion location and size. Exclusion methods fall into two categories, embolization and stent placement, and these procedures aim to exclude the pseudoaneurysm from the circulation and if possible to maintain distal blood flow. Embolization of...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-008-1053-3
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:To assess the heterogeneity of liver fat deposition with MR of the liver in type-2 diabetic (T2D) patients. METHODS:We enrolled 121 consecutive T2D patients. The reference standard was 3.0-T (1)H-MR spectroscopy. Hepatic steatosis was defined as liver fat content (LFC) ≥5.56 %. A triple-echo gradient-echo se...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-012-2468-4
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abstract:OBJECTIVES:To determine whether sirolimus has beneficial effects on lymphangioleiomyomatosis (LAM) lung cysts in CT with long-term follow-up (FU) and to investigate whether CT is an appropriate imaging biomarker to monitor and evaluate LAM progression. METHODS:In this retrospective study, 73 female patients diagnosed ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-019-06412-4
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abstract:OBJECTIVES:To assess whether contralateral parenchymal enhancement reproduces as an independent biomarker for patient survival in an independent patient cohort from a different cancer institution. METHODS:This is a HIPAA-compliant IRB approved retrospective study. Patients with ER-positive/HER2-negative operable invas...
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pub_type: 杂志文章
doi:10.1007/s00330-018-5470-7
更新日期:2018-11-01 00:00:00
abstract::A retrospective evaluation of the imaging of 13 patients with a diagnosis of osteoid osteoma (OO) of the spine was undertaken. Available imaging included radiographs (n=10), computed tomography (CT) (n=13), bone scintigraphy (n=5) and magnetic resonance imaging (MRI) (n=13). MRI features evaluated were pattern of neur...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-005-2816-8
更新日期:2005-12-01 00:00:00
abstract::The spectrum of radiographic findings in pulmonary infections due to M. tuberculosis (TB) and non-tuberculous mycobacteria (NTM) are being increasingly discussed, primarily as a result of the increasing prevalence of these infections. The NTM organisms are often overlooked as potential infecting organisms, diagnosis i...
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pub_type: 杂志文章,评审
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更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:To investigate the feasibility and clinical efficacy of ultrasound (US)-guided diffused optical tomography (DOT) in differentiating malignant breast lesions from benign lesions. MATERIAL AND METHODS:From October 2007 to August 2008, 198 women with 214 lesions scheduled for open biopsy were included in this s...
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abstract:OBJECTIVES:Metastatic breast cancer is a heterogeneous disease, commonly affecting the liver. We report our experience with (90)Y radioembolisation (RE) and its effects on the survival of patients with treatment-refractory breast cancer liver metastases. METHODS:A total of 77 female patients affected by breast cancer ...
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doi:10.1007/s00330-012-2556-5
更新日期:2013-01-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章,meta分析,评审
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/BF00619952
更新日期:1996-01-01 00:00:00
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pub_type: 杂志文章
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abstract::Hemochromatosis is a multisystem disorder produced by the excessive accumulation of iron in visceral organs and the musculoskeletal system. Clinically the disease may be silent, but characteristic radiological features may point to the diagnosis. The increased iron stores in the organs involved, especially in the live...
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pub_type: 杂志文章
doi:10.1007/s003300050274
更新日期:1997-01-01 00:00:00
abstract::The purpose of this study was to first evaluate Levovist (Schering, Berlin, Germany), an echo-contrast agent, during power Doppler sonography (PDS) in patients with synovitis using asymptomatic joints as controls. Then we evaluated the accuracy of this technique against contrast-enhanced MRI. Forty patients (19 men an...
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pub_type: 临床试验,杂志文章
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更新日期:2001-01-01 00:00:00
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pub_type: 临床试验,杂志文章
doi:10.1007/s00330-005-2817-7
更新日期:2006-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s003300050516
更新日期:1998-01-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,多中心研究
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更新日期:2018-10-01 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:European radiology
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更新日期:1998-01-01 00:00:00