Abstract:
OBJECTIVES:To assess whether contralateral parenchymal enhancement reproduces as an independent biomarker for patient survival in an independent patient cohort from a different cancer institution. METHODS:This is a HIPAA-compliant IRB approved retrospective study. Patients with ER-positive/HER2-negative operable invasive ductal carcinoma and preoperative dynamic contrast-enhanced MRI were consecutively included between 2005 and 2009. The parenchyma of the breast contralateral to known cancer was segmented automatically on MRI and contralateral parenchymal enhancement (CPE) was calculated. CPE was split into tertiles and tested for association with invasive disease-free survival (IDFS) and overall survival (OS). Propensity score analysis with inverse probability weighting (IPW) was used to adjust CPE for patient and tumour characteristics as well as systemic therapy. RESULTS:Three hundred and two patients were included. The median age at diagnosis was 48 years (interquartile range, 42-57). Median follow-up was 88 months (interquartile range, 76-102); 15/302 (5%) patients died and 37/302 (13%) had a recurrence or died. In context of multivariable analysis, IPW-adjusted CPE was associated with IDFS [hazard ratio (HR) = 0.27, 95% confidence interval (CI) = 0.05-0.68, p = 0.004] and OS (HR = 0.22, 95% CI = 0.00-0.83, p = 0.032). CONCLUSIONS:Contralateral parenchymal enhancement on pre-treatment dynamic contrast-enhanced MRI as an independent biomarker of survival in patients with ER-positive/HER2-negative breast cancer has been upheld in this study. These findings are a promising next step towards a practical and inexpensive test for risk stratification of ER-positive/HER2-negative breast cancer. KEY POINTS:• High parenchymal-enhancement in the disease-free contralateral breast reproduces as biomarker for survival. • This is in patients with ER-positive/HER2-negative breast cancer from an independent cancer centre. • This is independent of patient and pathology parameters and systemic therapy.
journal_name
Eur Radioljournal_title
European radiologyauthors
van der Velden BHM,Sutton EJ,Carbonaro LA,Pijnappel RM,Morris EA,Gilhuijs KGAdoi
10.1007/s00330-018-5470-7subject
Has Abstractpub_date
2018-11-01 00:00:00pages
4705-4716issue
11eissn
0938-7994issn
1432-1084pii
10.1007/s00330-018-5470-7journal_volume
28pub_type
杂志文章abstract::To prove the usefulness of a simple laser marker system (LMS) in target definition as well as examination procedure for CT-guided interventions, 130 cases of diagnostic biopsies and lumbal sympathectomies were compared. In 75 cases LMS and in 55 cases a simple crossgrid was used. Taking advantage of the LMS, the param...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300051054
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journal_title:European radiology
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journal_title:European radiology
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abstract:OBJECTIVES:Coronary artery volume indexed to left myocardial mass (CAVi), derived from coronary computed tomography angiography (CCTA), has been proposed as an indicator of diffuse atherosclerosis. We investigated the association of CAVi with quantitative flow parameters and its ability to predict ischemia as derived f...
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abstract::Coincidence of dorsal defect on a multipartite patella constitutes a rare cause of anterior knee pain in the first decades of life. Imaging findings of this uncommon symptomatic skeletal variant are discussed, with emphasis on MR features. ...
journal_title:European radiology
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journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300000433
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journal_title:European radiology
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更新日期:1997-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2005-07-01 00:00:00
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更新日期:2006-10-01 00:00:00
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