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Assessment of acute kidney injury with T1 mapping MRI following solid organ transplantation.

Abstract：

OBJECTIVES:To evaluate T1 mapping as a non-invasive, functional MRI biomarker in patients shortly after solid organ transplantation to detect acute postsurgical kidney damage and to correlate T1 times with renal function. METHODS:101 patients within 2 weeks after solid organ transplantation (49 kidney transplantation, 52 lung transplantation) and 14 healthy volunteers were examined by MRI between July 2012 and April 2015 using the modified Look-Locker inversion recovery (MOLLI) sequence. T1 times in renal cortex and medulla and the corticomedullary difference were compared between groups using one-way ANOVA adjusted for multiple comparison with the Tukey test, and T1 times were correlated with renal function using Pearson's correlation. RESULTS:Compared to healthy volunteers T1 times were significantly increased after solid organ transplantation in the renal cortex (healthy volunteers 987 ± 102 ms; kidney transplantation 1299 ± 101 ms, p < 0.001; lung transplantation 1058 ± 96 ms, p < 0.05) and to a lesser extent in the renal medulla. Accordingly, the corticomedullary difference was diminished shortly after solid organ transplantation. T1 changes were more pronounced following kidney compared to lung transplantation, were associated with the stage of renal impairment and significantly correlated with renal function. CONCLUSIONS:T1 mapping may be helpful for early non-invasive assessment of acute kidney injury and renal pathology following major surgery such as solid organ transplantation. KEY POINTS:• Renal cortical T1 relaxation times are prolonged after solid organ transplantation. • Cortical T1 values increase with higher stages of renal function impairment. • Corticomedullary difference decreases with higher stages of renal function impairment. • Renal cortical T1 relaxation time and corticomedullary difference correlate with renal function. • T1 mapping may be helpful for non-invasive assessment of post-operative renal pathology.

journal_name

Eur Radiol

journal_title

European radiology

authors

Peperhove M,Vo Chieu VD,Jang MS,Gutberlet M,Hartung D,Tewes S,Warnecke G,Fegbeutel C,Haverich A,Gwinner W,Lehner F,Bräsen JH,Haller H,Wacker F,Gueler F,Hueper K

doi

10.1007/s00330-017-4943-4

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

44-50

issue

eissn

0938-7994

issn

1432-1084

pii

10.1007/s00330-017-4943-4

journal_volume

pub_type

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Assessment of acute kidney injury with T1 mapping MRI following solid organ transplantation.