Abstract:
OBJECTIVES:Diagnostic accuracy of conventional coronary CT angiography (CCTAconv) may be compromised by blooming artifacts from calcifications or stents. Blooming artifacts may be reduced by subtraction coronary CT angiography (CCTAsub) in which non-contrast and contrast CT data sets are subtracted digitally. We tested whether CCTAsub in patients with severe coronary calcification or stents reduces the number of false-positive stenosis evaluations compared with CCTAconv. METHODS:In this study, 180 symptomatic patients scheduled for invasive coronary angiography (ICA) were prospectively enrolled and CT scanned (2013-2016) at three international centers. CCTAconv, and CCTAsub data sets were reconstructed. Target segments were defined as motion-free coronary segments with a suspected stenosis (> 50% of lumen) potentially due to blooming of either calcium or stents. Target segments were evaluated with respect to misregistration artifacts from the CCTAsub reconstruction process, in which case evaluation was omitted. CCTAsub and CCTAconv were compared with ICA. Primary outcome measure was the frequency of false positives by CCTAconv versus CCTAsub to identify > 50% coronary stenosis by ICA on a per-segment level. RESULTS:After exclusion of 76 patients, 104 (14% females) with mean age 67 years and median Agatston score 852 were included. There were 136 target segments with misregistration and 121 target segments without. Accuracy calculations in target segments without misregistration showed a reduction of the false positives from 72% [95% confidence interval (CI): 63-80%] in CCTAconv to 33% (CI:25-42%) in CCTAsub, at the expense of 7% (CI:3-14%) false negatives in CCTAsub. CONCLUSIONS:In severely calcified coronary arteries or stents, CCTAsub reduces the false-positive rate in well-aligned, calcified or stent segments suspected of significant stenosis on CCTAconv. Nevertheless, misregistration artifacts are frequent in CCTAsub. KEY POINTS:• A high calcium-score reduces the diagnostic accuracy in patients scanned with cardiac CT. • These patients would normally need an invasive angiogram for diagnosis. • In this prospective, multicenter study, subtraction CT, when evaluable, reduces false-positive stenosis evaluations. • Subtraction coronary CT angiography may, when evaluable, reduce excessive downstream testing.
journal_name
Eur Radioljournal_title
European radiologyauthors
Fuchs A,Kühl JT,Chen MY,Viladés Medel D,Alomar X,Shanbhag SM,Helqvist S,Kofoed KFdoi
10.1007/s00330-018-5418-ysubject
Has Abstractpub_date
2018-10-01 00:00:00pages
4077-4085issue
10eissn
0938-7994issn
1432-1084pii
10.1007/s00330-018-5418-yjournal_volume
28pub_type
杂志文章,多中心研究abstract:OBJECTIVES:To evaluate early post-operative magnetic resonance (EPMR) as a prognostic tool after resection of glioblastoma. METHODS:Sixty EPMR examinations were evaluated for perioperative infarct, tumour growth between diagnosis and EPMR, contrast enhancement pattern, and extent of resection (EOR). The EOR was approa...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-3914-x
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVES:To investigate the feasibility of low-concentration contrast media (LC-CM) in cerebral and cervical dual-energy CT angiography (DE-CTA) using an advanced monoenergetic (Mono+) reconstruction technique. METHODS:Sixty-five consecutive patients prospectively selected to undergo cerebral and cervical DE-CTA wer...
journal_title:European radiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00330-018-5407-1
更新日期:2018-10-01 00:00:00
abstract::Aim of this study was to develop a time-efficient sequence protocol for a 1.0 T dedicated MR system to be used for whole-organ scoring of osteoarthritis (OA). Thirty-four knees were examined using a protocol that included fat suppressed fast spin echo proton density weighted sequences (PDFS) in three planes plus a cor...
journal_title:European radiology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00330-004-2608-6
更新日期:2005-05-01 00:00:00
abstract::Intussusception represents the most common abdominal emergency in infancy. The classical clinical triad, consisting of abdominal colics, red jelly stools and a palpable mass, is only present in approximately 50% of cases, 20% of patients are symptom free at clinical presentation. Primary imaging modality of choice is ...
journal_title:European radiology
pub_type: 杂志文章,评审
doi:10.1007/s00330-003-2033-2
更新日期:2004-03-01 00:00:00
abstract::The aim of this study was to evaluate the value of automatic bolus tracking for monophasic spiral CT of the liver and to assess the liver-to-lesion conspicuity in comparison with time-delay examinations. In 40 patients scheduled for therapy control of known hypovascular hepatic metastases a monophasic spiral CT was co...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300000637
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:To assess the inhibitory effect of gadoxetate disodium on the transporter system using indocyanine green (ICG). MATERIALS AND METHODS:Groups of six female B6 Albino mice were injected with the test agent (0.62 mmol/kg gadoxetate disodium) or phosphate-buffered saline (control) 10 min before injection of ICG...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5403-5
更新日期:2018-10-01 00:00:00
abstract::Microvascular obstruction (MVO) is an important and independent determinant of post-infarct remodeling. Fifty-two patients with a successfully reperfused ST-segment elevation acute myocardial infarction (MI) were studied with MRI in the first week and at 4 months post-infarction. On early (i.e., 2-5 min) post-contrast...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-007-0627-9
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVES:Endovascular embolization is a valid option for the management of visceral artery aneurysms. Imaging is crucial for providing anatomical assessments, but preoperative non-invasive investigations may not be exhaustive. The aim of this work is to present preliminary experience with the use of three-dimensional...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-3820-2
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:Lung adenocarcinoma frequently manifests as subsolid nodules, and the solid portion and ground-glass-opacity (GGO) portion on CT have different prognostic significance. Therefore, current T descriptor, defined as the whole tumour diameter without discrimination between solid and GGO, is insufficient. We aime...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-4029-0
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:To assess epiphyseal growth plate closure of the knee for forensic age estimation using an ultrasound (US)-based method and to compare the findings with MRI. METHODS:Thirty-three healthy male individuals (age, 14.4-19.3 years) were prospectively evaluated for epiphyseal growth plate closure of the right kne...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07343-1
更新日期:2020-10-14 00:00:00
abstract:OBJECTIVES:This study was conducted in order to assess the performance of the Liver Imaging Reporting and Data System (LI-RADS) treatment response (TR) (LR-TR) categorization on gadoxetic acid-enhanced MRI (Gd-EOB-MRI) for detecting viable tumors in hepatocellular carcinoma (HCC) treated with locoregional treatment (LR...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-019-06623-9
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVES:To investigate the hepatobiliary enhancement patterns of gadoxetic acid (Gd-EOB-DTPA) MRI and the temporal evolution of focal nodular hyperplasia (FNH)-like lesions in pediatric cancer survivors. METHODS:We retrospectively included pediatric cancer survivors who had new liver lesions detected during surveil...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-020-07157-1
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVES:To develop a radiomics model for predicting hematoma expansion in patients with intracerebral hemorrhage (ICH) and to compare its predictive performance with a conventional radiological feature-based model. METHODS:We retrospectively analyzed 251 consecutive patients with acute ICH. Two radiologists indepen...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-019-06378-3
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:As stents for treating intracranial atherosclerotic stenosis may develop in-stent re-stenosis (ISR) in up to 30%, follow-up imaging is mandatory. Residual stenosis (RS) is not rare. We evaluated an optimised Flat Detector CT protocol with intravenous contrast material application (i.v. FD-CTA) for non-invasiv...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-010-1931-3
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVES:To assess the inter-operator concordance and the potential sources of discordance in defining response to sorafenib in hepatocellular carcinoma (HCC). METHODS:All patients who received sorafenib between September 2008 and February 2015 were scrutinised for this retrospective study. Images were evaluated sep...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-018-5393-3
更新日期:2018-09-01 00:00:00
abstract::Decompressive craniotomy in hemispheric infarction has been reported to reduce mortality and improve outcome. Identifying tissue at risk and monitoring the benefit of craniotomy is hardly practical and has not been reported thus far. Perfusion CT was applied before and immediately after decompressive craniotomy in a p...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-002-1656-z
更新日期:2003-08-01 00:00:00
abstract:OBJECTIVES:To evaluate the effect of hybrid iterative reconstruction on qualitative and quantitative parameters at 256-slice cardiac CT. METHODS:Prospective cardiac CT images from 20 patients were analysed. Paired image sets were created using 3 reconstructions, i.e. filtered back projection (FBP) and moderate- and hi...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-011-2361-6
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the performance of a computer-aided algorithm for automated stenosis detection at coronary CT angiography (cCTA). METHODS:We investigated 59 patients (38 men, mean age 58 +/- 12 years) who underwent cCTA and quantitative coronary angiography (QCA). All cCTA data sets were analyzed using a softwar...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-009-1644-7
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVES:To evaluate effects of a vascular-disrupting agent on rodent tumour models. METHODS:Twenty rats with liver rhabdomyosarcomas received ZD6126 intravenously at 20 mg/kg, and 10 vehicle-treated rats were used as controls. Multiple sequences, including diffusion-weighted imaging (DWI) and dynamic contrast-enhan...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-010-1743-5
更新日期:2010-08-01 00:00:00
abstract::The technique of using an electrode as a lever to increase the distance between renal cell carcinoma (RCC) and bowel during CT-guided radiofrequency ablation (RFA) is described. CT-guided percutaneous RFA was performed in two patients with two RCCs, which were in close proximity to the adjacent bowel. A sterile drape ...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-007-0816-6
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVES:To assess feasibility, image quality, and radiation dose of prospectively ECG-triggered coronary CT angiography (CTA) in orthotopic heart transplant (OHT) recipients. METHODS:47 consecutive OHT recipients (40 men, mean age 62.1 ± 10.9 years, mean heart rate 86.3 ± 14.4 bpm) underwent dual-source CTA to rule...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-011-2126-2
更新日期:2011-09-01 00:00:00
abstract::The aim of this study was to analyze the precision of tibial cartilage morphometry, by using a fast, coronal water-excitation sequence with high spatial resolution, to compare the reproducibility of 3D thickness vs volume estimates, and to test the technique in patients with severe osteoarthritis. The tibiae of 8 heal...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300050047
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:To report the frequencies of potentially relevant incidental findings in the general adult population and to develop a protocol for their management in whole-body magnetic resonance imaging (wb-MRI). METHODS:A total of 2,500 adult subjects (1,271 women, 1,229 men; mean age 53 years) from the population-base...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-012-2636-6
更新日期:2013-03-01 00:00:00
abstract::We describe a new dedicated ultrasound system for computer-guided large core breast biopsy (LCBB) and report our first clinical experience in 45 female patients. After an initial 30 biopsy procedures on a US breast phantom, LCBB using this new system was performed in 45 non-palpable surgically verified breast lesions....
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s003300101010
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:To evaluate the prognosis of "strict" high-risk nodules (small hepatocellular nodules detected only in the hepatobiliary phase of initial Gd-EOB-DTPA-enhanced MR examination) in patients with cirrhosis or chronic hepatitis. METHODS AND MATERIALS:The study included thirty-three patients with 60 "strict" high-ri...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-014-3293-8
更新日期:2014-10-01 00:00:00
abstract::The aim of this study was to compare MR imaging and endoscopic ultrasonography (EUS) for the local staging of rectal tumours. Forty-nine patients were examined on a 1.5-T MR unit using either a pelvic phased-array coil (n = 37) alone or combined with an endorectal coil (n = 12). Sagittal and axial sequences with T2-we...
journal_title:European radiology
pub_type: 临床试验,杂志文章
doi:10.1007/s003300050979
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:To find predictors of non-diagnostic repeat biopsy specimen acquisition for mutational analysis and detection of epidermal growth factor receptor (EGFR) T790M mutation. METHODS:We retrospectively reviewed 90 non-small cell lung cancer patients harbouring EGFR mutations who underwent repeat cone-beam CT-guid...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-017-5006-6
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVES:To develop an MRI enterography global score (MEGS) of Crohn's disease (CD) activity compared with a reference standard of faecal calprotectin (fC), C-reactive protein (CRP) and Harvey-Bradshaw index (HBI). METHODS:Calprotectin, CRP and HBI were prospectively recorded for 71 patients (median age 33, male 35)...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-013-3010-z
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to assess the protective effect of premedication and changing contrast media (CM) against repeat adverse reactions (ARs) to iodinated CM. METHODS:Between January 2006 and September 2014, 771 cases with previous ARs to CM were administered CM. The same CM that had caused ARs pre...
journal_title:European radiology
pub_type: 杂志文章
doi:10.1007/s00330-015-4028-1
更新日期:2016-07-01 00:00:00
abstract::To determine whether neutral contrast agents with water-equivalent intraluminal attenuation can improve delineation of the bowel wall and increase overall image quality for a non-selected patient population, a neutral oral contrast agent (3% mannitol) was administered to 100 patients referred for abdominal multidetect...
journal_title:European radiology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00330-008-0958-1
更新日期:2008-09-01 00:00:00