Abstract:
OBJECTIVES:Lung adenocarcinoma frequently manifests as subsolid nodules, and the solid portion and ground-glass-opacity (GGO) portion on CT have different prognostic significance. Therefore, current T descriptor, defined as the whole tumour diameter without discrimination between solid and GGO, is insufficient. We aimed to determine the prognostic significance of solid tumour size and attempt to include prognostic factors such as tumour disappearance rate (TDR) on CT and SUVmax on PET/CT. METHODS:Five hundred and ninety-five patients with completely resected lung adenocarcinoma were analyzed. We developed a nomogram using whole tumour size, TDR, and SUVmax. External validation was performed in another 102 patients. RESULTS:In patients with tumours measuring ≤2 cm and >2 to 3 cm, disease free survival (DFS) was significantly associated with solid tumour size (P < 0.001), but not with whole tumour size (P = 0.052). Developed nomogram was significantly superior to the conventional T stage (area under the curve of survival ROC; P = 0.013 by net reclassification improvement) in stratification of patient survival. In the external validation group, significant difference was noted in DFS according to proposed T stage (P = 0.009). CONCLUSIONS:Nomogram-based T descriptors provide better prediction of survival and assessment of individual risks than conventional T descriptors. KEY POINTS:• Current measurement of whole tumour diameter including ground-glass opacity is insufficient • TDR enables differentiation between invasive solid portion and non-invasive GGO portion • SUVmax demonstrates the biological aggressiveness of the tumour • We developed a nomogram using whole tumour size, TDR, and SUVmax • Nomogram-based clinical T descriptors provide better prediction of survival.
journal_name
Eur Radioljournal_title
European radiologyauthors
Song SH,Ahn JH,Lee HY,Lee G,Choi JY,Kang J,Kim EY,Han J,Kwon OJ,Lee KS,Kim HK,Choi YS,Kim J,Shim YMdoi
10.1007/s00330-015-4029-0subject
Has Abstractpub_date
2016-06-01 00:00:00pages
1538-46issue
6eissn
0938-7994issn
1432-1084pii
10.1007/s00330-015-4029-0journal_volume
26pub_type
杂志文章abstract:PURPOSE:To analyse the accuracy of dual-energy contrast-enhanced spectral mammography in dense breasts in comparison with contrast-enhanced subtracted mammography (CESM) and conventional mammography (Mx). MATERIALS AND METHODS:CESM cases of dense breasts with histological proof were evaluated in the present study. Fou...
journal_title:European radiology
pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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journal_title:European radiology
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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abstract:OBJECTIVES:To investigate the correlation of right ventricular (RV) to left ventricular (LV) volume ratio measured by chest CT with pulmonary arterial systolic pressure (PASP) estimated by echocardiography. METHODS:104 patients (72.47 ± 13.64 years; 39 male) who had undergone chest CT and echocardiography were divided...
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pub_type: 杂志文章,meta分析,评审
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更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:1996-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2002-08-01 00:00:00