Carcinoid tumours: predicting the location of the primary neoplasm based on the sites of metastases.

Abstract:

OBJECTIVES:To predict the primary neuroendocrine tumour of the gastrointestinal tract site based on observed metastatic sites. METHODS:We studied data from the radiology database of a single, large cancer centre on 250 patients with pathologically confirmed neuroendocrine tumours. Primary tumour sites and the locations of metastases were collected from pathologic and radiologic reports of all available imaging modalities, such as computed tomography (CT), positron emission tomography (PET/CT), magnetic resonance imaging (MRI) and octreotide scans in the database. A nominal regression model was used to predict primary tumour site using the observed metastatic sites. Regression coefficients that were not statistically significant at the 5 % level were eliminated from the model in a stepwise procedure. RESULTS:Lung and liver metastases were not statistically significant predictors of the location of primary tumours (p = 0.86 and 0.074, respectively); whereas, lymph node, bone, and peritoneal metastases were significant predictors (p < 0.0001, 0.0004, and 0.014, respectively). CONCLUSIONS:Metastatic neuroendocrine tumours to the lymph nodes, bone, and peritoneum can be used to predict the primary neuroendocrine site; however, metastases in the lung and liver alone cannot predict the site of the primary tumour site.

journal_name

Eur Radiol

journal_title

European radiology

authors

Bhosale P,Shah A,Wei W,Varadhachary G,Johnson V,Shah V,Kundra V

doi

10.1007/s00330-012-2615-y

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

400-7

issue

2

eissn

0938-7994

issn

1432-1084

journal_volume

23

pub_type

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