Identifying the most infectious lesions in pulmonary tuberculosis by high-resolution multi-detector computed tomography.

Abstract:

OBJECTIVE:This study aimed to determine whether characteristics detected by multi-detector computed tomography (MDCT) were predictive of highly infectious, smear-positive, active pulmonary tuberculosis (PTB). METHODS:Among 124 patients with active PTB, 84 had positive (group 1) and 40 had negative (group 2) smear results for acid-fast bacilli. Multiplanar MDCT, axial conventional CT and chest X-ray images were analysed retrospectively for morphology, number, and segmental (lobe) distribution of lesions. RESULTS:By multivariate analysis, consolidation over any segment of the upper, middle, or lingual lobes, cavitations, and clusters of nodules were associated with group 1, while centrilobular nodules were predictive of group 2. Using five independent variables associated with risk in group 1, a prediction model was created to distinguish between group 1 and group 2. ROC curve analysis showed an area under the curve of 0.951 +/- 0.021 for this prediction model. With the ideal cutoff point score of 1, the sensitivity, specificity, and positive predictive values were 84.5%, 97.5%, and 98.0%, respectively. CONCLUSIONS:A model to predict smear-positive active PTB on the basis of findings from MDCT may be a useful tool for clinical decisions about isolating patients pending sputum smear results.

journal_name

Eur Radiol

journal_title

European radiology

authors

Yeh JJ,Chen SC,Teng WB,Chou CH,Hsieh SP,Lee TL,Wu MT

doi

10.1007/s00330-010-1796-5

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

2135-45

issue

9

eissn

0938-7994

issn

1432-1084

journal_volume

20

pub_type

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