Principles and clinical applications of image analysis.

abstract：:Simple, inexpensive procedures for rapid identification of the common bacterial pathogens are outlined in detail. When the tests are judiciously applied, most isolates can be identified within minutes or hours, and strains that require more extensive testing for accurate identification will be recognized. ...

journal_title：Clinics in laboratory medicine

authors： Barry AL

更新日期：1985-03-01 00:00:00

abstract：:Disturbed liver parenchymal cell function adversely impacts on the hemostasis system, the extent of which correlates with the degree of liver disease. Because liver parenchymal cells synthesize most factors of the clotting and the fibrinolytic systems, levels of these procoagulant and anticoagulant as well as profibri...

journal_title：Clinics in laboratory medicine

authors： Mammen EF

更新日期：1994-12-01 00:00:00

abstract：:The era of prenatal screening for serious birth defects began in the 1970s with the discovery that amniotic fluid and maternal serum levels of alpha-fetoprotein (AFP) were increased in pregnancies affected by fetal open neural tube defects. Since then, prenatal screening has become a part of routine obstetric care. In...

journal_title：Clinics in laboratory medicine

authors： Canick JA,Kellner LH,Bombard AT

更新日期：2003-06-01 00:00:00

abstract：:Shiga toxin-producing Escherichia coli (STEC) are important enteric pathogens worldwide, causing diarrhea with or without blood visibly present and hemolytic uremic syndrome. STEC are unique among diarrheogenic E coli in producing Shiga toxin type 1 and type 2, the virulence factors responsible for bloody diarrhea and...

journal_title：Clinics in laboratory medicine

authors： Hunt JM

更新日期：2010-03-01 00:00:00

abstract：:Concern for illicit and restricted drug use in otolaryngology is similar to other surgical specialties with a few notable exceptions. Many illicit drugs are consumed transnasally. Repeated nasal exposure to stimulants or narcotics can cause local tissue destruction that can present as chronic rhinosinusitis or nasosep...

journal_title：Clinics in laboratory medicine

authors： Gonik NJ,Bluth MH

更新日期：2016-12-01 00:00:00

abstract：:Point-of-care testing is an emerging specialty in laboratory medicine and has attracted considerable interest in the medical literature. This article presents a general overview of point-of-care testing including its history, menu, clinical utility, aspects of analytical performance, regulatory issues, and management ...

journal_title：Clinics in laboratory medicine

authors： Lee-Lewandrowski E,Lewandrowski K

更新日期：2001-06-01 00:00:00

abstract：:Diseases due to nontuberculous mycobacteria are increasing in frequency, especially in patients with compromised immunity. A number of "new" mycobacterial species have been described in the last decade, largely as the result of the use of new tools to identify previously unrecognized mycobacteria found in the environm...

journal_title：Clinics in laboratory medicine

authors： Herdman AV,Steele JC Jr

更新日期：2004-09-01 00:00:00

abstract：:At the present time, the use of molecular techniques for diagnosing the neurologic porphyrias is limited mainly to those laboratories doing research in the area. Because any of four genes may be involved, it is important to confirm the diagnosis in the index case before undertaking molecular investigation. With advanc...

journal_title：Clinics in laboratory medicine

authors： Schreiber WE

更新日期：1997-03-01 00:00:00

abstract：:Screening tests may help or harm the healthy subject and, therefore, must be selected and used carefully. Criteria for selection include characteristics of the disease(s), of the potential screening tests, and of the population(s) to be screened. An understanding of methods used to evaluate tests will allow the invest...

journal_title：Clinics in laboratory medicine

authors： Mulley AG

更新日期：1986-06-01 00:00:00

abstract：:Nephropathy progressing to end-stage renal failure is a common complication of diabetes mellitus. The development of diabetic nephropathy is preceded for many years by minor increases in urine albumin excretion (microalbuminuria), and some diabetologists believe that by reducing or reversing this early abnormality, po...

journal_title：Clinics in laboratory medicine

authors： Hindmarsh JT

更新日期：1988-09-01 00:00:00

abstract：:In marked contrast to their historical classification as relatively harmless, common cold-causing, respiratory pathogens, human coronaviruses (HCoVs) are associated with more severe clinical complications, as emphasized by the discovery of severe acute respiratory syndrome-associated CoV (SARS-CoV) in 2003. Still, the...

journal_title：Clinics in laboratory medicine

authors： Wevers BA,van der Hoek L

更新日期：2009-12-01 00:00:00

abstract：:Normal thermogenesis requires a complex interaction between systems that generate and dissipate heat. Serving as director of thermogenesis, the hypothalamus activates the sympathetic nervous system along with the thyroid and adrenal glands to respond to changes in body temperature. Working in concert, these systems re...

journal_title：Clinics in laboratory medicine

authors： Rusyniak DE,Sprague JE

更新日期：2006-03-01 00:00:00

abstract：:It is necessary to determine the safety of polymeric materials through laboratory and animal testing before biomedical use can become more widespread. This article describes many of the methods used in analyzing the toxicology and biocompatibility of potentially important biomedical polymers. The study method used in ...

journal_title：Clinics in laboratory medicine

authors： Laurencin CT,Pierre-Jacques HM,Langer R

更新日期：1990-09-01 00:00:00

abstract：:After more than 6 decades of clinical practice, the transplant community continues to research noninvasive biomarkers of solid organ injury to help improve patient care. In this review, we discuss the clinical usefulness of selective biomarkers and how they are processed at the laboratory. In addition, we organize the...

journal_title：Clinics in laboratory medicine

authors： Choi J,Bano A,Azzi J

更新日期：2019-03-01 00:00:00

abstract：:The cause of colorectal cancer (CRC) is multifactorial, with genetic, molecular, inflammatory, and environmental risk factors. Recently, the gut microbiota has been recognized as a new environmental contributor to CRC in both animal models and human studies. An additional interplay of the gut microbiome with inflammat...

journal_title：Clinics in laboratory medicine

authors： Cho M,Carter J,Harari S,Pei Z

更新日期：2014-12-01 00:00:00

abstract：:The antiphospholipid syndrome (APS) is an autoimmune disorder presenting with tissue injury in various organs attributed to large or small vessel thrombosis or, in some instances, possible nonthrombotic inflammatory mechanisms, associated with in vitro evidence of antibodies to certain proteins, or proteinphospholipid...

journal_title：Clinics in laboratory medicine

authors： Eby C

更新日期：2009-06-01 00:00:00

abstract：:Bioregulators are naturally occurring organic compounds that regulate a multitude of biologic processes. Under natural circumstances, bioregulators are synthesized in minute quantities in a variety of living organisms and are essential for physiologic homeostasis. In the wrong hands, these compounds have the capabilit...

journal_title：Clinics in laboratory medicine

authors： Kagan E

更新日期：2006-06-01 00:00:00

abstract：:Transfusion medicine is a rapidly evolving specialty, and efforts are ongoing to improve the safety and quality of blood component therapy. Leukocytes are known to be the cause of numerous adverse effects of transfusion therapy, and their removal from red cells and platelet components may be desirable in a variety of ...

journal_title：Clinics in laboratory medicine

authors： Klapper EB,Goldfinger D

更新日期：1992-12-01 00:00:00

abstract：:At the start of the twenty-first century, a dramatic change occurred in the clinical laboratory community. Concepts from Metrology, the science of measurement, began to be formally applied to clinical laboratory field methods, resulting in a new appreciation of metrological calibrator traceability. It is a change beca...

journal_title：Clinics in laboratory medicine

authors： Armbruster D

更新日期：2017-03-01 00:00:00

abstract：:Standard business inventory procedures can be cost effective when they are adapted to hospital laboratory inventory management in a 500-bed hospital. The investment in a central laboratory store-room and one additional employee yields financial benefits and indirect service benefits. The system requires consistent use...

journal_title：Clinics in laboratory medicine

authors： Weinstein W,Wenk RE

更新日期：1985-12-01 00:00:00

abstract：:This article attempts to define and identify sources of variation in laboratory analysis that occur predominantly "away" from the analytic bench. Problems in the derivation and application of reference ranges are reviewed and sources of non-analytic error are "located" within the entire testing cycle. Reference source...

journal_title：Clinics in laboratory medicine

authors： Bachner P

更新日期：1986-12-01 00:00:00

abstract：:The subject of this article is privacy and its relationship to the activities of health care organizations. Privacy is a good quality that each individual may possess. The quality of an individual's privacy is a personal determination. Although everyday life requires that we attempt to understand and protect the priva...

journal_title：Clinics in laboratory medicine

authors： Essin DJ

更新日期：1999-06-01 00:00:00

abstract：:Severe adverse drug reactions are a common cause of morbidity and mortality. Some of the most severe reactions are immunologically mediated and have been linked to specific HLA alleles. The mechanisms underlying HLA-associated drug hypersensitivity are complex and not fully understood. Recent findings have provided in...

journal_title：Clinics in laboratory medicine

authors： Schutte RJ,Sun Y,Li D,Zhang F,Ostrov DA

更新日期：2018-12-01 00:00:00

abstract：:In discussing quality assurance in the blood bank, where many of the standard statistical techniques of measuring accuracy simply do not apply, three questions come to mind: How much? How often? Who says? Because of severe changes in the prospective payment plan and a new interest in cost effectiveness, many transfusi...

journal_title：Clinics in laboratory medicine

authors： White KK,Silberstein LE

更新日期：1986-12-01 00:00:00

abstract：:This article reviews the laboratory methodologies used to evaluate acute lymphoblastic leukemia (ALL) in children and their role in establishing a diagnosis and prognosis of this disease. These methodologies are: morphology, flow cytometry, cytogenetics, and molecular diagnostics. Additionally, immunophenotypic classi...

journal_title：Clinics in laboratory medicine

authors： Melnick SJ

更新日期：1999-03-01 00:00:00

abstract：:There are multiple levels of transcriptional regulation that a cell can bring to bear on either native cellular genes or integrated proviral genes. One such level of regulation is inducible sequence-specific transcriptional factors, such as NF-kappa B, which have been extensively investigated with respect to the HIV-1...

journal_title：Clinics in laboratory medicine

authors： Laughlin MA,Pomerantz RJ

更新日期：1994-06-01 00:00:00

abstract：:Recent studies have brought remarkable progress in the understanding of cellular, subcellular, and molecular mechanisms of endothelial injury and responses to injury, both of which appear to be integral parts of the acute inflammatory response. The possible roles of endothelial surface enzymes in the inflammatory resp...

journal_title：Clinics in laboratory medicine

authors： Ryan US,Ryan JW

更新日期：1983-12-01 00:00:00

abstract：:Formal medical and public health microbiology (MPHM) fellowship programs play a key role in preparing future clinical microbiology laboratory directors for their leadership and management responsibilities. Given the continually evolving MPHM field, fellowships must remain adaptable to changes in the field, providing t...

journal_title：Clinics in laboratory medicine

authors： Pritt BS,Bowler CA,Theel ES

更新日期：2020-12-01 00:00:00

abstract：:Several major pet-food and human-food safety incidents occurred worldwide between 2003 and 2008, causing illnesses and deaths in children, cats, dogs, and pigs. During the 2007 outbreak of renal failure in dogs and cats in the United States, veterinary diagnostic laboratories helped identify melamine and melamine anal...

journal_title：Clinics in laboratory medicine

authors： Puschner B,Reimschuessel R

更新日期：2011-03-01 00:00:00

abstract：:Diagnostic procedures for the detection of malaria differ considerably depending on the aims of evaluation. The current requirements of any laboratory procedure for general application to the detection and diagnosis of malaria include: sensitivity, specificity, simplicity in application, unambiguous interpretation, an...

journal_title：Clinics in laboratory medicine

authors： Makler MT,Gibbins B

更新日期：1991-12-01 00:00:00