Toxicology and biocompatibility considerations in the evaluation of polymeric materials for biomedical applications.

abstract：:Chromosome analysis is the genetic technique useful in evaluating endocrine disease. Indications for cytogenetic studies include suspected sex chromosomal aneuploidies as well as repeated fetal wastage. In patients with ambiguous genitalia, cytogenetic studies are mandatory, not only to provide information for assigni...

journal_title：Clinics in laboratory medicine

authors： Gordon LP

更新日期：1984-12-01 00:00:00

abstract：:Acute accidental iron poisoning is a common serious and potentially fatal intoxication in the young child. Approximately 1 per cent of such poisoning have a fatal outcome, and outcome is closely related to the early onset of coma or shock. Long-term prognosis is excellent for all survivors of the acute episode, althou...

journal_title：Clinics in laboratory medicine

authors： Henretig FM,Temple AR

更新日期：1984-09-01 00:00:00

abstract：:Methodologic aspects including causes of factitious hyperphosphatemia and hypophosphatemia are summarized. The differential diagnosis of hyperphosphatemia is reviewed under its three broad causes: decreased glomerular filtration rate, increased exogenous or endogenous phosphate load, and increased renal tubular phosph...

journal_title：Clinics in laboratory medicine

authors： Bourke E,Yanagawa N

更新日期：1993-03-01 00:00:00

abstract：:Lyme disease in North America is caused by infection with the spirochetal bacterium Borrelia burgdorferi and transmitted by Ixodes scapularis and Ixodes pacificus ticks. These ticks also have the potential to transmit a rapidly expanding list of other pathogenic bacteria, viruses, and parasites, including Anaplasma ph...

journal_title：Clinics in laboratory medicine

authors： Caulfield AJ,Pritt BS

更新日期：2015-12-01 00:00:00

abstract：:Osteoporosis (low bone mass) depends on the peak bone mass attained and bone loss after the peak. Sex steroids (estrogens and androgens) have an impact on both processes. In this article the roles and mechanisms of estrogens and androgens are discussed in relation to clinical osteoporosis. Other hormones and hormone-l...

journal_title：Clinics in laboratory medicine

authors： Adler RA

更新日期：2000-09-01 00:00:00

abstract：:The pharmacologic field that studies antimicrobial pharmacokinetics and pharmacodynamics (PK/PD) has had a major impact on the choice and dosing regimens used for many antibiotics especially those used in the treatment of respiratory tract infections. PK/PD parameters are particularly important in light of increasing ...

journal_title：Clinics in laboratory medicine

authors： Andes D,Anon J,Jacobs MR,Craig WA

更新日期：2004-06-01 00:00:00

abstract：:Simple, inexpensive procedures for rapid identification of the common bacterial pathogens are outlined in detail. When the tests are judiciously applied, most isolates can be identified within minutes or hours, and strains that require more extensive testing for accurate identification will be recognized. ...

journal_title：Clinics in laboratory medicine

authors： Barry AL

更新日期：1985-03-01 00:00:00

abstract：:This article reviews the concept of dysplasia and the distinguishing features of dysplastic nevi, including their premalignant potential, their biologic markers of tumor progression, and their reproducibly recognizable clinical and histologic characteristics. An additional emphasis is placed on describing gray zone m...

journal_title：Clinics in laboratory medicine

authors： Kim JC,Murphy GF

更新日期：2000-12-01 00:00:00

abstract：:With the US Food and Drug Administration's recent label change of warfarin to include genetic testing for warfarin sensitivity, manufacturers are developing assays, and laboratories are offering testing. This article describes the genetic variants for which testing is available. Current technologies and assays are com...

journal_title：Clinics in laboratory medicine

authors： Lyon E,McMillin G,Melis R

更新日期：2008-12-01 00:00:00

abstract：:The red cell indices of mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration have been standard methods of evaluating anemia since they were developed by Wintrobe in the 1930s. This article discusses the technical variabilities that have rendered the classic red cell indi...

journal_title：Clinics in laboratory medicine

authors： Savage RA

更新日期：1993-12-01 00:00:00

abstract：:Image processing applications in forensic pathology are becoming increasingly important. This article introduces basic concepts in image processing as applied to problems in forensic pathology in a non-mathematical context. Discussions of contrast enhancement, digital encoding, compression, deblurring, and other topic...

journal_title：Clinics in laboratory medicine

authors： Oliver WR

更新日期：1998-03-01 00:00:00

abstract：:Disturbed liver parenchymal cell function adversely impacts on the hemostasis system, the extent of which correlates with the degree of liver disease. Because liver parenchymal cells synthesize most factors of the clotting and the fibrinolytic systems, levels of these procoagulant and anticoagulant as well as profibri...

journal_title：Clinics in laboratory medicine

authors： Mammen EF

更新日期：1994-12-01 00:00:00

abstract：:The antiphospholipid syndrome (APS) is an autoimmune disorder presenting with tissue injury in various organs attributed to large or small vessel thrombosis or, in some instances, possible nonthrombotic inflammatory mechanisms, associated with in vitro evidence of antibodies to certain proteins, or proteinphospholipid...

journal_title：Clinics in laboratory medicine

authors： Eby C

更新日期：2009-06-01 00:00:00

abstract：:To overcome the significant mortality associated with ovarian cancer, a highly sensitive and specific screening test is urgently needed. CA-125 testing is used to monitor response to chemotherapy, detect recurrence, and detect late stage ovarian cancer. However, CA-125 testing, alone or in combination with ultrasonogr...

journal_title：Clinics in laboratory medicine

authors： Kim K,Visintin I,Alvero AB,Mor G

更新日期：2009-03-01 00:00:00

abstract：:An exciting era exists as a result of the introduction of novel markers of myocardial damage. The prognostic implications of troponins, even in the setting of "minor myocardial damage," are potentially of immense value to patient care. We need to take the next step and assess the outcomes of interventions in these set...

journal_title：Clinics in laboratory medicine

authors： Tymchak WJ,Armstrong PW

更新日期：1997-12-01 00:00:00

abstract：:Melanoma represents a substantial source of risk within dermatology and dermatopathology. This article seeks to provide general pathologists, dermatologists and dermatopathologists with an overview of the basics principles of medical malpractice litigation, a review of the essentials of reporting and the importance of...

journal_title：Clinics in laboratory medicine

authors： High WA

更新日期：2008-06-01 00:00:00

abstract：:Automated image processing analysis for leukocyte differential counting started 30 years ago principally as a mimic of the traditional microscopic method. Several types of systems were used in the 1970s and 1980s. In the late 1990s, two new image processing systems were developed with new technology for cell image ana...

journal_title：Clinics in laboratory medicine

authors： Tatsumi N,Pierre RV

更新日期：2002-03-01 00:00:00

abstract：:Drug testing of patients in a psychiatric outpatient service is an effective way to identify patients who relapse into renewed use of drugs of abuse and in monitoring the effectiveness of ongoing medical and psychological therapy. Most of this testing involves the analysis of urine specimens with immunoassays. Hair te...

journal_title：Clinics in laboratory medicine

authors： Shearer DS,Baciewicz GJ,Kwong TC

更新日期：1998-12-01 00:00:00

abstract：:This study examines the relationship between D-dimer concentration and patient age, gender, race, and renal function, and the role of D-dimer concentration as a predictor of in-hospital mortality, in a critically ill patient population. The results demonstrate there is a correlation between increased D-dimer concentra...

journal_title：Clinics in laboratory medicine

authors： Spring JL,Winkler A,Levy JH

更新日期：2014-09-01 00:00:00

abstract：:Diabetes mellitus affects almost 16 million Americans. It has become a major public health problem and the number one cause of adult blindness, end-stage renal disease, and nontraumatic amputations in the United States. It also markedly increases the risk for cardiovascular, cerebrovascular, and peripheral artery dise...

journal_title：Clinics in laboratory medicine

authors： Kazi AA,Blonde L

更新日期：2001-03-01 00:00:00

abstract：:Certain serum autoantibodies serve as useful diagnostic markers in AiLD; however, the etiology and pathogenesis of AiLD remain unknown. Although AiLD is characterized by the presence of autoantibodies and other humoral immune abnormalities, there is significant evidence that cell-mediated immune mechanisms are critica...

journal_title：Clinics in laboratory medicine

authors： Bylund DJ,McHutchison J

更新日期：1997-09-01 00:00:00

abstract：:Cytomorphological examination of aspirate smears remains the basic method to diagnose hematologic disorders and to evaluate treatment-related changes. Last-generation hematological analyzers can count, besides cells normally circulating in peripheral blood, some types of immature and abnormal cells, such as erythrobla...

journal_title：Clinics in laboratory medicine

authors： d'Onofrio G,Zini G

更新日期：2015-03-01 00:00:00

abstract：:The development of assay techniques for the analysis of tumor markers in tissue extracts and in the peripheral circulation has had a major impact on the diagnosis and management of patients with endocrine neoplasms. In addition to eutopic and ectopic hormones, a variety of other tumor-derived products, including endoc...

journal_title：Clinics in laboratory medicine

authors： DeLellis RA

更新日期：1990-03-01 00:00:00

abstract：:This article focuses on current clinical laboratory testing to diagnose Alzheimer disease and monitor its progression throughout its disease course. Several clinically available tests focus on analysis of amyloid and tau levels in cerebrospinal fluid as well as autosomal dominant and risk factor genes. Although the cu...

journal_title：Clinics in laboratory medicine

authors： Winder Z,Wilcock D,Jicha GA

更新日期：2020-09-01 00:00:00

abstract：:Fine needle aspiration biopsy (FNAB) is the diagnostic procedure of choice for evaluation of liver lesions. Although primarily applied to malignant disease, it is also used in the evaluation of benign conditions. Improvements in imaging techniques and advances in cytologic interpretations, as well as production of new...

journal_title：Clinics in laboratory medicine

authors： Pitman MB

更新日期：1998-09-01 00:00:00

abstract：:Susceptibility testing of microorganisms isolated from blood cultures should follow the guidelines of the NCCLS in the selection of antimicrobial agents and the method for testing. Standardized testing can be performed on isolated colonies from pure subcultures of the blood/broth mixture. Direct susceptibility testing...

journal_title：Clinics in laboratory medicine

authors： Mirrett S

更新日期：1994-03-01 00:00:00

abstract：:Drugs ingested in overdose can have altered pharmacokinetics of absorption, distribution, and elimination. The pathophysiologic consequences of overdose can also change a drug's pharmacokinetic properties. Many toxicologic interventions are based on modifying the drug's pharmacokinetics (e.g., impairing absorption or ...

journal_title：Clinics in laboratory medicine

authors： Platt D

更新日期：1990-06-01 00:00:00

abstract：:Seven different mycoplasmas have been isolated from the human genitourinary tract. The diseases they cause or with which they have been associated are described. Diagnosis of infection by cultural and noncultural (antigen detection, DNA probes) methods is discussed in detail. The more useful serologic procedures are i...

journal_title：Clinics in laboratory medicine

authors： Taylor-Robinson D

更新日期：1989-09-01 00:00:00

abstract：:India is a global leader in diabetes, currently with second largest pool of diabetes in the world. Asian Indian phenotype is uniquely predisposed to develop type 2 diabetes because of strong familial aggregation as well lifestyle factors of imprudent diet and sedentary physical habit. The typical Asian Indian phenotyp...

journal_title：Clinics in laboratory medicine

authors： Joshi SR

更新日期：2012-06-01 00:00:00

abstract：:A formal therapeutic drug monitoring consultation service (TDMCS) will enhance the clinical benefits of drug level determinations. It can result in decreased length of stay and improved risk management posture. The successful implementation of a TDMCS requires the coordinated efforts of a multidisciplinary team that m...

journal_title：Clinics in laboratory medicine

authors： Wilkinson DS

更新日期：1987-06-01 00:00:00