Abstract:
:This prospective randomized study is to evaluate the locoregional failure and its impact on survival by comparing involved field radiotherapy (IFRT) with elective nodal irradiation (ENI) in combination with concurrent chemotherapy for locally advanced non-small cell lung cancer. It appears that higher dose could be delivered in IFRT arm than that in ENI arm, and IFRT did not increase the risk of initially uninvolved or isolated nodal failures. Both a tendency of improved locoregional progression-free survival and a significant increased overall survival rate are in favor of IFRT arm in this study.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Chen M,Bao Y,Ma HL,Hu X,Wang J,Wang Y,Peng F,Zhou QC,Xie CHdoi
10.1155/2013/371819subject
Has Abstractpub_date
2013-01-01 00:00:00pages
371819eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
杂志文章,随机对照试验abstract::A series of amides derived from vanillic acid were obtained by coupling reactions using PyBOP ((Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate) and DCC (Dicyclohexylcarbodiimide) coupling reagents. These were submitted to biological evaluation for species of Candida, Staphylococcus, and Pseudomonas...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9209676
更新日期:2019-04-15 00:00:00
abstract:Background:Methadone Maintenance Treatment (MMT) program's success depends on the likelihood of reducing drop-out rate and keeping patients remaining in the program. There have been neither comprehensive studies about variation among patients who have been experiencing MMT for long period nor prediction of MMT period i...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9081968
更新日期:2018-08-07 00:00:00
abstract:Purpose:Fractures are common among all types of paediatric injuries, with differences in incidence over time. Here, we present the epidemiologic features of traumatic fractures in a population of youth ≤ 18 years of age who were admitted to our university-affiliated hospitals from 2002 to 2010. Methods:We retrospectiv...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2019/8019063
更新日期:2019-02-20 00:00:00
abstract::Recently published evidence has raised concerns about worse late mortality and increasing need for reintervention after off-pump coronary artery bypass grafting. We undertook this study to assess the impact of off-pump coronary artery bypass grafting on survival and freedom from reintervention at 10 years. From Januar...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/602871
更新日期:2013-01-01 00:00:00
abstract::Freshly ejaculated spermatozoa are incapable or poorly capable of fertilizing an oocyte. The fertilization aptness of spermatozoa depends on the appropriate and time-dependent acquisition of hyperactivation, chemotaxis, capacitation, and the acrosome reaction, where calcium (Ca(2+)) is extensively involved in almost e...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/841615
更新日期:2014-01-01 00:00:00
abstract::The aim of the present study was to investigate the suitability of insoluble Eudragit® water dispersions (NE, NM, RL, and RS) for direct high-shear granulation of very soluble levetiracetam in order to decrease its burst effect from HPMC K100M matrices. The process characteristics, ss-NMR analysis, in vitro dissolutio...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/8043415
更新日期:2019-03-05 00:00:00
abstract::Macrophages, especially their activation state, are closely related to the progression of diabetic nephropathy. Classically activated macrophages (M1) are proinflammatory effectors, while alternatively activated macrophages (M2) exhibit anti-inflammatory properties. 1,25-Dihydroxyvitamin D3 has renoprotective roles th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/157834
更新日期:2015-01-01 00:00:00
abstract::Densitometry data generated for Western blots are commonly used to compare protein abundance between samples. In the last decade, it has become apparent that assumptions underpinning these comparisons are often violated in studies reporting Western blot data in the literature. These violations can lead to erroneous in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5214821
更新日期:2019-01-21 00:00:00
abstract::Human epididymis protein 4 (HE4) is an available tumor biomarker mainly for detecting ovarian cancer. However, it is unknown whether it can be a novel indicator for diagnosis of diabetic kidney disease (DKD). The aim of this study was to investigate the possibility of serum HE4 as a novel biomarker for DKD in patients...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4831459
更新日期:2019-11-11 00:00:00
abstract::Introduction. The aim of the present study was to determine the closeness of agreement between a self-reported and an objective measure of physical activity in low back pain patients and healthy controls. Beyond, influencing factors on overestimation were identified. Methods. 27 low back pain patients and 53 healthy c...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1497213
更新日期:2016-01-01 00:00:00
abstract::Brain injury such as traumatic brain injury (TBI) and stroke is the major cause of long-term disabilities in many countries. The increasing rate of brain damaged victims and the heterogeneity of impairments decrease rehabilitation effectiveness and competence resulting in higher cost of rehabilitation treatment. On th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/493562
更新日期:2015-01-01 00:00:00
abstract::Tomatoes and tomato based-foods contain beneficial microorganisms and various organic acids that have important nutritional values for human. The objective of this study was to access the physiochemical properties of fermented tomatoes juices and to evaluate the competitiveness of lactic acid bacteria (LAB) against Li...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6937837
更新日期:2019-02-26 00:00:00
abstract::Clear cell renal cell carcinoma (ccRCC) is one of the most common cancers in the world. Our aim is to identify prognostic biomarkers that contribute to the progression of early stage ccRCC and clarify the mechanism. Here, the mRNA microarray expression profile of ccRCC samples was obtained from Gene Expression Omnibus...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2064582
更新日期:2020-10-29 00:00:00
abstract::Txndc9 (thioredoxin domain containing protein 9) has been shown to be involved in mammalian mitosis; however, its function in mammalian oocyte meiosis remains unclear. In this study, we initially found that Txndc9 is expressed during meiotic maturation of mouse oocytes and higher expression of Txndc9 mRNA and protein ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6265890
更新日期:2017-01-01 00:00:00
abstract::Medicinal plants have played an important role in the treatment of many diseases. Medicinal plants are believed to be well appropriate with the human body and to produce less side influences than the pharmaceuticals. Kingdom of Saudi Arabia has abundant and wide variety of medicinal plants whose therapeutic effects ha...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3596287
更新日期:2019-02-27 00:00:00
abstract::Restriction enzymes are the main defence system against foreign DNA, in charge of preserving genome integrity. Lactococcus raffinolactis BGTRK10-1 expresses LraI Type II restriction-modification enzyme, whose activity is similar to that shown for EcoRI; LraI methyltransferase protects DNA from EcoRI cleavage. The gene...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5657085
更新日期:2018-01-29 00:00:00
abstract::Patients with left ventricle (LV) volume overload (VO) remain in a compensated state for many years although severe dilation is present. The myocardial capacity to fulfill its energetic demand may delay decompensation. We performed a gene expression profile, a model of chronic VO in rat LV with severe aortic valve reg...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/949624
更新日期:2015-01-01 00:00:00
abstract::The aim of the present study was to evaluate the antitumor potential of iminoflavones in in vitro and in vivo anticancer models. Preliminary screening in various cancer cell lines revealed four potential iminoflavones out of which IMF-8 was taken based on its activity against colon cancer cells. This was further confi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/569130
更新日期:2014-01-01 00:00:00
abstract::Variations in human genome (e.g., single nucleotide polymorphisms, SNPs) may be associated with hereditary diseases, their complications, comorbidities, and drug responses. Using Web service SNP_TATA_Comparator presented in our previous paper, here we analyzed immediate surroundings of known SNP markers of diseases an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8642703
更新日期:2016-01-01 00:00:00
abstract:Introduction:The incidence of acute kidney injury (AKI) considerably increases the mortality rate in polytrauma victims. Undoubtedly, early identification of patients at risk is crucial for timely implementation of preventive strategies in order to improve their prognosis. Therefore, we aimed to investigate if serum ne...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2687584
更新日期:2018-11-06 00:00:00
abstract::Heat shock proteins 70 and heat shock proteins 90 (Hsp70/90) have been implicated in many crucial steps of carcinogenesis: stabilizing oncogenic proteins, inhibiting programmed cell death and replicative senescence, induction of tumor angiogenesis, and activation of the invasion and metastasis. Plenty of cancer relate...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/239164
更新日期:2014-01-01 00:00:00
abstract::Studies on the occurrence of pharmaceuticals show that the widely used pharmaceuticals ibuprofen and diclofenac are present in relevant concentrations in the environment. A pilot plant treating hospital wastewater with relevant concentrations of these pharmaceuticals was evaluated for its performance to reduce the con...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/325806
更新日期:2013-01-01 00:00:00
abstract::Abdominal pregnancy is a very rare form of ectopic pregnancy, associated with high morbidity and mortality for both fetus and mother. It is, and often, seen in poor resource nations, where early diagnosis is often a major challenge due to poor prenatal care and lack of medical resources. An advanced abdominal pregnanc...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/102479
更新日期:2014-01-01 00:00:00
abstract::Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases. The enhanced nitrative stress plays an important role in homocysteine-induced endothelial dysfunction. Previous studies have showed that phytoestrogen α -zearalanol alleviated endothelial injury in ovariectomized hyperhomocysteinemic rats;...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2013/813450
更新日期:2013-01-01 00:00:00
abstract::Dengue fever, a reemerging disease, is putting nearly 2.5 billion people at risk worldwide. The number of infections and the geographic extension of dengue fever infection have increased in the past decade. The disease is caused by the dengue virus, a flavivirus that uses mosquitos Aedes sp. as vectors. The disease ha...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/825039
更新日期:2014-01-01 00:00:00
abstract:Background:Existing literature suggests that an association exists between coronary artery disease (CAD) and carpal tunnel syndrome (CTS), but few researchers have explored whether CTS is a risk for CAD. Materials and Methods:This large case-control study explored the association between CTS and CAD, using health insu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3171925
更新日期:2019-03-03 00:00:00
abstract:INTRODUCTION:Tuberculosis is still one of the most important health problems in developing countries and increasing drug resistance is the main concern for its treatment. This study was designed to characterize the drug resistant Mycobacterium tuberculosis isolated from patients suffering from pulmonary tuberculosis in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/747085
更新日期:2015-01-01 00:00:00
abstract::Plant-associated bacteria provide important services to host plants. Environmental factors such as cultivar type and pedoclimatic conditions contribute to shape their diversity. However, whether these environmental factors may influence the plant growth promoting (PGP) potential of the root-associated bacteria is not ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/491091
更新日期:2013-01-01 00:00:00
abstract::Epigenetic changes have major role in the normal development and programming of gene expression. Aberrant methylation results in carcinogenesis. The primary objective of our study is to determine whether primary tumor tissue and cultured tumor cells in 2D and 3D tissue culture systems have the same methylation signatu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1407167
更新日期:2019-01-17 00:00:00
abstract::Schistosomiasis, caused by infection with Schistosoma species, remains an important parasitic zoonosis. Thioredoxin glutathione reductase of Schistosoma japonicum (SjTGR) plays an important role in the development of the parasite and for its survival. Here we present a recombinant plasmid DNA vaccine, pVAX1/SjTGR, to ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/952416
更新日期:2013-01-01 00:00:00