A review of urinary angiotensin converting enzyme 2 in diabetes and diabetic nephropathy.

Abstract:

:Urinary angiotensin converting enzyme 2 (ACE2) is significantly increased in diabetes and diabetic nephropathy. While studies on its clinical significance are still underway, its urinary expression, association with metabolic and renal parameters has been in the recent past considerably studied. The recent studies have demystified urine ACE2 in many ways and suggested the roles it could play in the management of diabetic nephropathy. In all studies the expression of urinary ACE2 was determined by enzyme activity assay and/with the quantification of ACE2 protein and mRNA by methods whose reliability are yet to be evaluated. This review summarizes recent findings on expression of urinary ACE2, examines its relationship with clinical parameters and highlights possible applications in management of diabetic nephropathy.

journal_name

Biochem Med (Zagreb)

journal_title

Biochemia medica

authors

Gilbert A,Liu J,Cheng G,An C,Deo K,Gorret AM,Qin X

doi

10.11613/BM.2019.010501

subject

Has Abstract

pub_date

2019-02-15 00:00:00

pages

010501

issue

1

eissn

1330-0962

issn

1846-7482

pii

bm-29-1-010501

journal_volume

29

pub_type

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