Abstract:
:Urinary angiotensin converting enzyme 2 (ACE2) is significantly increased in diabetes and diabetic nephropathy. While studies on its clinical significance are still underway, its urinary expression, association with metabolic and renal parameters has been in the recent past considerably studied. The recent studies have demystified urine ACE2 in many ways and suggested the roles it could play in the management of diabetic nephropathy. In all studies the expression of urinary ACE2 was determined by enzyme activity assay and/with the quantification of ACE2 protein and mRNA by methods whose reliability are yet to be evaluated. This review summarizes recent findings on expression of urinary ACE2, examines its relationship with clinical parameters and highlights possible applications in management of diabetic nephropathy.
journal_name
Biochem Med (Zagreb)journal_title
Biochemia medicaauthors
Gilbert A,Liu J,Cheng G,An C,Deo K,Gorret AM,Qin Xdoi
10.11613/BM.2019.010501subject
Has Abstractpub_date
2019-02-15 00:00:00pages
010501issue
1eissn
1330-0962issn
1846-7482pii
bm-29-1-010501journal_volume
29pub_type
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