IMPACT Observatory: tracking the evolution of clinical trial data sharing and research integrity.

abstract：INTRODUCTION:The aim of this work is twofold. Firstly, to study the temporal evolution in the number of laboratory requests from primary care without clinical indication, and to analyse the number of such requests before and after the implementation of an automated requesting procedure. Secondly, to investigate what ar...

journal_title：Biochemia medica

authors： Salinas M,López-Garrigós M,Flores E,Leiva-Salinas M,Esteban P,Ahumada M,Leiva-Salinas C

更新日期：2016-10-15 00:00:00

abstract：:Diagnostic tests are important clinical tools. Bayes' theorem and Bayesian approach are important methods for interpreting test results. The Bayesian factor, the so-called likelihood ratio, has not always been well-understood. In this article, we try to discuss the likelihood ratio and its value for a specific test re...

journal_title：Biochemia medica

authors： Habibzadeh F,Habibzadeh P

更新日期：2019-06-15 00:00:00

abstract：Introduction:The evaluation of patients with suspected appendicitis strives to identify all patients with presenting symptoms while minimizing negative appendectomy rate. The aim of the study was to identify the optimal combination of clinical and laboratory parameters that should facilitate the emergency department su...

journal_title：Biochemia medica

authors： Soldo I,Radisic Biljak V,Bakula B,Bakula M,Simundic AM

更新日期：2018-10-15 00:00:00

abstract：INTRODUCTION:ISO 15189 was a new standard published in 2003 for accrediting medical laboratories. We believe that some requirements of the ISO 15189 standard are especially difficult to meet for majority of laboratories. The aim of this article was to present the frequency of nonconformities to requirements of the ISO ...

journal_title：Biochemia medica

authors： Ho B,Ho E

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:Many additional tasks in the Stat laboratory (SL) increase the workload. It is necessary to control them because they can affect the service provided by the laboratory. Our aim is to calculate these tasks, study their evolution over a 10 year period, and compare turnaround times (TAT) in summer period to t...

journal_title：Biochemia medica

authors： Salinas M,López-Garrigós M,Flores E,Leiva-Salinas M,Lillo R,Leiva-Salinas C

更新日期：2016-01-01 00:00:00

abstract：Introduction:Macroprolactinaemia is a well-known analytical problem in diagnostics of hyperprolactinaemia usually detected with polyethylene glycol (PEG) precipitation method. Since there is no harmonization in macroprolactin detection and reporting results, this study proposes and evaluates the usefulness of in-house ...

journal_title：Biochemia medica

authors： Šostarić M,Bokulić A,Marijančević D,Zec I

更新日期：2019-06-15 00:00:00

abstract：INTRODUCTION:Glycolysis affects glucose determination in vitro. The placement of sample tubes in ice-water slurry with plasma separation within 30 minutes is recommended, or alternatively the use of a glycolysis inhibitor. The aim of our two-steps study was to evaluate which Terumo tube is best for glucose determinatio...

journal_title：Biochemia medica

authors： Bonetti G,Carta M,Montagnana M,Lo Cascio C,Bonfigli AR,Mosca A,Testa R,Italian joint SIBioC-SIPMeL Study Group on Diabetes Mellitus.

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:In vitro human diagnostic (IVD) company recalls are a common practice aimed to either minimize a potential error or eliminate an existing failure. In this case report, we aim to provide a critical analysis of a recent IVD recall and to provide a practical framework about what to do when an IVD company reca...

journal_title：Biochemia medica

authors： Lima-Oliveira G,Lippi G,Salvagno GL,Brocco G,Guidi GC

更新日期：2015-06-05 00:00:00

abstract：:Extravascular body fluids (EBF) analysis can provide useful information in the differential diagnosis of conditions that caused their accumulation. Their unique nature and particular requirements accompanying EBF analysis need to be recognized in order to minimize possible negative implications on patient safety. This...

journal_title：Biochemia medica

authors： Milevoj Kopcinovic L,Culej J,Jokic A,Bozovic M,Kocijan I

更新日期：2020-02-15 00:00:00

abstract：INTRODUCTION:Urinary tract infection (UTI) is one of the most common bacterial infectious diseases in children. The aim of this study was to determine the total prooxidant and antioxidant capacity of children with UTI, as well as changes of oxidative status parameters according to acute inflammation persistence and acu...

journal_title：Biochemia medica

authors： Petrovic S,Bogavac-Stanojevic N,Kotur-Stevuljevic J,Peco-Antic A,Ivanisevic I,Ivanisevic J,Paripovic D,Jelic-Ivanovic Z

更新日期：2014-01-01 00:00:00

abstract：Introduction:This study aimed to investigate the analytical bias in haematological parameters induced by storage at 33 ºC. Materials and methods:Blood from the diversion pouch of 20 blood donors were collected in K 2 EDTA vials and stored at 33 ºC. Readings from each vial ...

journal_title：Biochemia medica

authors： Jain A,Jain S,Singh N,Aswal P,Pal S,Meinia SK,Chowdhury N

更新日期：2018-06-15 00:00:00

abstract：:Reliable procedures are needed to quantify the performance of instruments and methods in order to increase the quality in clinical laboratories. The Sigma metrics serves that purpose, and in the present study, the current methods for the calculation of the Sigma metrics are critically evaluated. Although the conventio...

journal_title：Biochemia medica

authors： Oosterhuis WP,Coskun A

更新日期：2018-06-15 00:00:00

abstract：:In laboratory medicine, several studies have described the most frequent errors in the different phases of the total testing process, and a large proportion of these errors occur in the pre-analytical phase. Schemes for registration of errors and subsequent feedback to the participants have been conducted for decades ...

journal_title：Biochemia medica

authors： Kristensen GB,Aakre KM,Kristoffersen AH,Sandberg S

更新日期：2014-02-15 00:00:00

abstract：:Peer review is widely used system for evaluating manuscripts prior to publication. It has been and still is widely used tool for making justified and fair editorial decision. However, the evidence of its efficacy is limited and it has been criticized to be time-consuming, biased, inconsistent, conservative, and open t...

journal_title：Biochemia medica

authors： Smolčić VŠ,Simundić AM

更新日期：2014-10-15 00:00:00

abstract：Introduction:Liquid chromatography coupled to atmospheric pressure ionization tandem mass spectrometry (LC-ESI-MS/MS) is currently considered the reference method for quantitative determination of urinary free cortisol (UFC). One of the major drawbacks of this measurement is a particular form of matrix effect, conventi...

journal_title：Biochemia medica

authors： Danese E,Salvagno GL,Guzzo A,Scurati S,Fava C,Lippi G

更新日期：2017-10-15 00:00:00

abstract：:Logistic regression is used to obtain odds ratio in the presence of more than one explanatory variable. The procedure is quite similar to multiple linear regression, with the exception that the response variable is binomial. The result is the impact of each variable on the odds ratio of the observed event of interest....

journal_title：Biochemia medica

authors： Sperandei S

更新日期：2014-02-15 00:00:00

abstract：Introduction:Reference intervals (RIs) for complement assays in EDTA plasma samples have not previously been published. The objectives of the present study were to validate and/or determine RIs for classical pathway (CP50) activity and C3c, C4 and C1 inhibitor protein (C1INH) assays and to assess the need for age-speci...

journal_title：Biochemia medica

authors： Lopez B,Bertier N,Ledoult E,Joudinaud R,Maanaoui M,Majerus V,Moitrot E,Deleplancque AS,Rogeau S,Launay D,Lefèvre G,Labalette M,Dubucquoi S

更新日期：2019-10-15 00:00:00

abstract：Introduction:Autovalidation (AV) is an algorithm based on predefined rules designed, among others, to automate and standardize the postanalytical phase of laboratory work. The aim of this study was to examine the overall opinion of Croatian medical biochemistry laboratories regarding various aspects of AV. Material an...

journal_title：Biochemia medica

authors： Rimac V,Jokic A,Podolar S,Vlasic Tanaskovic J,Honovic L,Lenicek Krleza J

更新日期：2020-06-15 00:00:00

abstract：:Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes mellitus (DM) and a leading cause of blindness in working-age adults in developed countries. Numerous investigations have recognised inflammation and angiogenesis as important factors in the development of this complication of ...

journal_title：Biochemia medica

authors： Kaštelan S,Orešković I,Bišćan F,Kaštelan H,Gverović Antunica A

更新日期：2020-10-15 00:00:00

abstract：INTRODUCTION:Duplicate measurements can be used to describe the performance and analytical robustness of assays and to identify outliers. We performed about 235,000 duplicate measurements of nine routinely measured quantities and evaluated the observed differences between the replicates to develop new markers for analy...

journal_title：Biochemia medica

authors： Neubig S,Grotevendt A,Kallner A,Nauck M,Petersmann A

更新日期：2017-02-15 00:00:00

abstract：Introduction:It is often quoted that 70% of clinical decisions are based on laboratory results, but the evidence to substantiate this claim is lacking. Since clinical guidelines aim to document best-practice decision making for specific disease conditions, inclusion of any laboratory test means that the best available ...

journal_title：Biochemia medica

authors： Hicks AJ,Carwardine ZL,Hallworth MJ,Kilpatrick ES

更新日期：2021-02-15 00:00:00

abstract：:An increasing prevalence of gestational diabetes has become a very challenging task in prenatal care worldwide. International Association of Diabetes and Pregnancy Study Groups (IADPSG) has recently issued recommendations on the diagnosis and classification of hyperglycaemia in pregnancy. These recommendations, the fi...

journal_title：Biochemia medica

authors： Lovrencić MV,Honović L,Kralik S,Matica J,Prasek M,Pape-Medvidović E,Ivanisević M,Delmis J

更新日期：2013-01-01 00:00:00

abstract：:This systematic review presents the latest trends in salivary research and its applications in health and disease. Among the large number of analytes present in saliva, many are affected by diverse physiological and pathological conditions. Further, the non-invasive, easy and cost-effective collection methods prompt a...

journal_title：Biochemia medica

authors： Nunes LA,Mussavira S,Bindhu OS

更新日期：2015-06-05 00:00:00

abstract：INTRODUCTION:The aim of this study is to present a case of 44 years old woman with topiramate induced metabolic acidosis and kidney stones. MATERIALS AND METHODS:The laboratory features of topiramate caused renal tubular acidosis in blood and urine during topiramate treatment, with correction of metabolic acidosis by ...

journal_title：Biochemia medica

authors： Salek T,Andel I,Kurfurstova I

更新日期：2017-06-15 00:00:00

abstract：Introduction:In recent years, Six Sigma metrics has became the hotspot in all trades and professions, which contributes a general procedure to explain the performance on sigma scale. Nowadays, many large companies, such as General Healthcare, Siemens, etc., have applied Six Sigma to clinical medicine and achieved satis...

journal_title：Biochemia medica

authors： Mao X,Shao J,Zhang B,Wang Y

更新日期：2018-06-15 00:00:00

abstract：:Eosinophil cationic protein (ECP) is a heterogeneous molecule originating from activated eosinophil granulocytes. Biological activity and the cellular content of ECP are determined by genetic and posttranslational factors. Several single nucleotide polymorphisms (SNPs) in human ECP gene (RNASE3) have been described so...

journal_title：Biochemia medica

authors： Topic RZ,Dodig S

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:The phlebotomists' procedures are a still source of laboratory variability. The aim of this study was to verify the efficacy of minor modification in procedure for collection of diagnostic blood specimens by venipuncture from CLSI H03-A6 document is able to reduce the tourniquet application time. MATERIAL...

journal_title：Biochemia medica

authors： Lima-Oliveira G,Lippi G,Salvagno GL,Montagnana M,Picheth G,Guidi GC

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:We examined the cost-effectiveness of the three different D-dimer measurements in the screening of DVT in models with and without calculation of pre-test probability (PTP) score. Moreover, we calculated the minimal cost in DVT detection. MATERIAL AND METHODS:In the group of 192 patients with clinically su...

journal_title：Biochemia medica

authors： Bogavac-Stanojević N,Dopsaj V,Jelić-Ivanović Z,Lakić D,Vasić D,Petrova G

更新日期：2013-01-01 00:00:00

abstract：Introduction:Dyslipidaemia contributes to the occurrence of colorectal cancer (CRC). We hypothesized that qualitative changes of lipoproteins are associated with the risk for CRC development. This study analyses low-density lipoprotein (LDL) and high-density lipoprotein (HDL) diameters, as well as distribution of LDL a...

journal_title：Biochemia medica

authors： Stevanovic M,Vekic J,Bogavac-Stanojevic N,Janac J,Stjepanovic Z,Zeljkovic D,Trifunovic B,Spasojevic-Kalimanovska V,Zeljkovic A

更新日期：2018-10-15 00:00:00

abstract：INTRODUCTION:Winter swimming represents an intensive short-term exposure to cold, and thus it is considered a strong physical stress. Cold-based treatments, i.e. immersions in cold water, are spreading in sport medicine for improving recovery following muscle traumas, although a universal acceptance of that method is n...

journal_title：Biochemia medica

authors： Lombardi G,Ricci C,Banfi G

更新日期：2011-01-01 00:00:00