Clinical and diagnostic utility of saliva as a non-invasive diagnostic fluid: 
a systematic review.

Abstract:

:This systematic review presents the latest trends in salivary research and its applications in health and disease. Among the large number of analytes present in saliva, many are affected by diverse physiological and pathological conditions. Further, the non-invasive, easy and cost-effective collection methods prompt an interest in evaluating its diagnostic or prognostic utility. Accumulating data over the past two decades indicates towards the possible utility of saliva to monitor overall health, diagnose and treat various oral or systemic disorders and drug monitoring. Advances in saliva based systems biology has also contributed towards identification of several biomarkers, development of diverse salivary diagnostic kits and other sensitive analytical techniques. However, its utilization should be carefully evaluated in relation to standardization of pre-analytical and analytical variables, such as collection and storage methods, analyte circadian variation, sample recovery, prevention of sample contamination and analytical procedures. In spite of all these challenges, there is an escalating evolution of knowledge with the use of this biological matrix.

journal_name

Biochem Med (Zagreb)

journal_title

Biochemia medica

authors

Nunes LA,Mussavira S,Bindhu OS

doi

10.11613/BM.2015.018

subject

Has Abstract

pub_date

2015-06-05 00:00:00

pages

177-92

issue

2

eissn

1330-0962

issn

1846-7482

pii

bm-25-177

journal_volume

25

pub_type

杂志文章,评审
  • Laboratory diagnostics of chronic kidney disease in Croatia: state of the art.

    abstract:INTRODUCTION:Early identification and management of chronic kidney disease (CKD) is highly cost-effective and can reduce the risk of kidney failure progression and cardiovascular disease. In 2014, the Joint Croatian Working Group (JCWG) for laboratory diagnostic of CKD on the behalf of Croatian society of medical bioch...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2015.009

    authors: Biljak VR,Honović L,Matica J,Knežević B,Vojak SŠ

    更新日期:2015-01-01 00:00:00

  • Effect of winter swimming on haematological parameters.

    abstract:INTRODUCTION:Winter swimming represents an intensive short-term exposure to cold, and thus it is considered a strong physical stress. Cold-based treatments, i.e. immersions in cold water, are spreading in sport medicine for improving recovery following muscle traumas, although a universal acceptance of that method is n...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/bm.2011.014

    authors: Lombardi G,Ricci C,Banfi G

    更新日期:2011-01-01 00:00:00

  • Classical pathway activity C3c, C4 and C1-inhibitor protein reference intervals determination in EDTA plasma.

    abstract:Introduction:Reference intervals (RIs) for complement assays in EDTA plasma samples have not previously been published. The objectives of the present study were to validate and/or determine RIs for classical pathway (CP50) activity and C3c, C4 and C1 inhibitor protein (C1INH) assays and to assess the need for age-speci...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2019.030707

    authors: Lopez B,Bertier N,Ledoult E,Joudinaud R,Maanaoui M,Majerus V,Moitrot E,Deleplancque AS,Rogeau S,Launay D,Lefèvre G,Labalette M,Dubucquoi S

    更新日期:2019-10-15 00:00:00

  • Redefinition of gestational diabetes mellitus: implications for laboratory practice in Croatia.

    abstract::An increasing prevalence of gestational diabetes has become a very challenging task in prenatal care worldwide. International Association of Diabetes and Pregnancy Study Groups (IADPSG) has recently issued recommendations on the diagnosis and classification of hyperglycaemia in pregnancy. These recommendations, the fi...

    journal_title:Biochemia medica

    pub_type: 社论

    doi:10.11613/bm.2013.002

    authors: Lovrencić MV,Honović L,Kralik S,Matica J,Prasek M,Pape-Medvidović E,Ivanisević M,Delmis J

    更新日期:2013-01-01 00:00:00

  • A review of urinary angiotensin converting enzyme 2 in diabetes and diabetic nephropathy.

    abstract::Urinary angiotensin converting enzyme 2 (ACE2) is significantly increased in diabetes and diabetic nephropathy. While studies on its clinical significance are still underway, its urinary expression, association with metabolic and renal parameters has been in the recent past considerably studied. The recent studies hav...

    journal_title:Biochemia medica

    pub_type: 杂志文章,评审

    doi:10.11613/BM.2019.010501

    authors: Gilbert A,Liu J,Cheng G,An C,Deo K,Gorret AM,Qin X

    更新日期:2019-02-15 00:00:00

  • Inflammatory and angiogenic biomarkers in diabetic retinopathy.

    abstract::Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes mellitus (DM) and a leading cause of blindness in working-age adults in developed countries. Numerous investigations have recognised inflammation and angiogenesis as important factors in the development of this complication of ...

    journal_title:Biochemia medica

    pub_type: 杂志文章,评审

    doi:10.11613/BM.2020.030502

    authors: Kaštelan S,Orešković I,Bišćan F,Kaštelan H,Gverović Antunica A

    更新日期:2020-10-15 00:00:00

  • Test validation, method comparison and reference range for the measurement of β-hydroxybutyrate in peripheral blood samples.

    abstract:Introduction:The measurement of β-hydroxybutyrate (βOHB) concentrations is a corner stone of the diagnosis of diabetic ketoacidosis and other ketonic states. The aim of this study was to perform a validation of a peripheral blood βOHB assay (Randox) on a Roche cobas c502 analyser and to establish a βOHB reference range...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2020.010707

    authors: Kraus FB,Kocijancic M,Kluttig A,Ludwig-Kraus B

    更新日期:2020-02-15 00:00:00

  • Education of medical biochemists in Bosnia and Herzegovina.

    abstract::In this paper we would like to briefly introduce readers to the situation in the field of laboratory medicine in Bosnia and Herzegovina, with a focus on training in the field of medical biochemistry. As in some of neighboring countries, term Medical biochemist is the usual name for the Clinical biochemist or Clinical ...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:

    authors: Winterhalter-Jadrić M,Causević A,Jadrić R,Corić J,Hasić S,Kiseljaković E

    更新日期:2011-01-01 00:00:00

  • Economic evaluation of different screening alternatives for patients with clinically suspected acute deep vein thrombosis.

    abstract:INTRODUCTION:We examined the cost-effectiveness of the three different D-dimer measurements in the screening of DVT in models with and without calculation of pre-test probability (PTP) score. Moreover, we calculated the minimal cost in DVT detection. MATERIAL AND METHODS:In the group of 192 patients with clinically su...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/bm.2013.012

    authors: Bogavac-Stanojević N,Dopsaj V,Jelić-Ivanović Z,Lakić D,Vasić D,Petrova G

    更新日期:2013-01-01 00:00:00

  • Analytical robustness of nine common assays: frequency of outliers and extreme differences identified by a large number of duplicate measurements.

    abstract:INTRODUCTION:Duplicate measurements can be used to describe the performance and analytical robustness of assays and to identify outliers. We performed about 235,000 duplicate measurements of nine routinely measured quantities and evaluated the observed differences between the replicates to develop new markers for analy...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2017.021

    authors: Neubig S,Grotevendt A,Kallner A,Nauck M,Petersmann A

    更新日期:2017-02-15 00:00:00

  • Eosinophil cationic protein--current concepts and controversies.

    abstract::Eosinophil cationic protein (ECP) is a heterogeneous molecule originating from activated eosinophil granulocytes. Biological activity and the cellular content of ECP are determined by genetic and posttranslational factors. Several single nucleotide polymorphisms (SNPs) in human ECP gene (RNASE3) have been described so...

    journal_title:Biochemia medica

    pub_type: 杂志文章,评审

    doi:10.11613/bm.2011.019

    authors: Topic RZ,Dodig S

    更新日期:2011-01-01 00:00:00

  • The likelihood ratio and its graphical representation.

    abstract::Diagnostic tests are important clinical tools. Bayes' theorem and Bayesian approach are important methods for interpreting test results. The Bayesian factor, the so-called likelihood ratio, has not always been well-understood. In this article, we try to discuss the likelihood ratio and its value for a specific test re...

    journal_title:Biochemia medica

    pub_type: 杂志文章,评审

    doi:10.11613/BM.2019.020101

    authors: Habibzadeh F,Habibzadeh P

    更新日期:2019-06-15 00:00:00

  • The effective reduction of tourniquet application time after minor modification of the CLSI H03-A6 blood collection procedure.

    abstract:INTRODUCTION:The phlebotomists' procedures are a still source of laboratory variability. The aim of this study was to verify the efficacy of minor modification in procedure for collection of diagnostic blood specimens by venipuncture from CLSI H03-A6 document is able to reduce the tourniquet application time. MATERIAL...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/bm.2013.037

    authors: Lima-Oliveira G,Lippi G,Salvagno GL,Montagnana M,Picheth G,Guidi GC

    更新日期:2013-01-01 00:00:00

  • ICMJE authorship criteria are not met in a substantial proportion of manuscripts submitted to Biochemia Medica.

    abstract:INTRODUCTION:Our aim was to investigate if: (a) authors of Biochemia Medica meet authorship criteria given by International Committee of Medical Journal Editors (ICMJE), (b) authorship violations are more frequent in submissions containing some type of scientific misconduct. MATERIALS AND METHODS:Self-reported authors...

    journal_title:Biochemia medica

    pub_type: 杂志文章,评审

    doi:10.11613/BM.2015.033

    authors: Šupak-Smolčić V,Mlinarić A,Antončić D,Horvat M,Omazić J,Šimundić AM

    更新日期:2015-10-15 00:00:00

  • Oxidative status parameters in children with urinary tract infection.

    abstract:INTRODUCTION:Urinary tract infection (UTI) is one of the most common bacterial infectious diseases in children. The aim of this study was to determine the total prooxidant and antioxidant capacity of children with UTI, as well as changes of oxidative status parameters according to acute inflammation persistence and acu...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2014.029

    authors: Petrovic S,Bogavac-Stanojevic N,Kotur-Stevuljevic J,Peco-Antic A,Ivanisevic I,Ivanisevic J,Paripovic D,Jelic-Ivanovic Z

    更新日期:2014-01-01 00:00:00

  • The chi-square test of independence.

    abstract::The Chi-square statistic is a non-parametric (distribution free) tool designed to analyze group differences when the dependent variable is measured at a nominal level. Like all non-parametric statistics, the Chi-square is robust with respect to the distribution of the data. Specifically, it does not require equality o...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/bm.2013.018

    authors: McHugh ML

    更新日期:2013-01-01 00:00:00

  • The most common nonconformities encountered during the assessments of medical laboratories in Hong Kong using ISO 15189 as accreditation criteria.

    abstract:INTRODUCTION:ISO 15189 was a new standard published in 2003 for accrediting medical laboratories. We believe that some requirements of the ISO 15189 standard are especially difficult to meet for majority of laboratories. The aim of this article was to present the frequency of nonconformities to requirements of the ISO ...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/bm.2012.027

    authors: Ho B,Ho E

    更新日期:2012-01-01 00:00:00

  • Scientific author names: errors, corrections, and identity profiles.

    abstract::Authorship problems are deep-rooted in the field of science communication. Some of these relate to lack of specific journal instructions. For decades, experts in journal editing and publishing have been exploring the authorship criteria and contributions deserving either co-authorship or acknowledgment. The issue of i...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2016.017

    authors: Gasparyan AY,Yessirkepov M,Gerasimov AN,Kostyukova EI,Kitas GD

    更新日期:2016-01-01 00:00:00

  • Utility of routine laboratory preoperative tests based on previous results: Time to give up.

    abstract:INTRODUCTION:The usefulness and cost-effectiveness of routine laboratory preoperative tests (POTs) have been challenged recently. In fact, the American Society of Anesthesiologists (ASA) Task Force has stated that test results obtained from the medical record within 6 months of surgery generally are mostly acceptable. ...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2017.030902

    authors: Rodríguez-Borja E,Corchon-Peyrallo A,Aguilar-Aguilar G,Carratala-Calvo A

    更新日期:2017-10-15 00:00:00

  • Indications for laboratory tests in primary care: assessment of the most frequent indications and requests with blank clinical information.

    abstract:INTRODUCTION:The aim of this work is twofold. Firstly, to study the temporal evolution in the number of laboratory requests from primary care without clinical indication, and to analyse the number of such requests before and after the implementation of an automated requesting procedure. Secondly, to investigate what ar...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2016.045

    authors: Salinas M,López-Garrigós M,Flores E,Leiva-Salinas M,Esteban P,Ahumada M,Leiva-Salinas C

    更新日期:2016-10-15 00:00:00

  • Evaluating analytical quality in clinical biochemistry laboratory using Six Sigma.

    abstract:Introduction:In recent years, Six Sigma metrics has became the hotspot in all trades and professions, which contributes a general procedure to explain the performance on sigma scale. Nowadays, many large companies, such as General Healthcare, Siemens, etc., have applied Six Sigma to clinical medicine and achieved satis...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2018.020904

    authors: Mao X,Shao J,Zhang B,Wang Y

    更新日期:2018-06-15 00:00:00

  • Interrater reliability: the kappa statistic.

    abstract::The kappa statistic is frequently used to test interrater reliability. The importance of rater reliability lies in the fact that it represents the extent to which the data collected in the study are correct representations of the variables measured. Measurement of the extent to which data collectors (raters) assign th...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:

    authors: McHugh ML

    更新日期:2012-01-01 00:00:00

  • IMPACT Observatory: tracking the evolution of clinical trial data sharing and research integrity.

    abstract:INTRODUCTION:The opening of research data is emerging thanks to the increasing possibilities of digital technology. The opening of clinical trial (CT) data is a part of this process, expected to have positive scientific, ethical, health, and economic impacts thus contributing to research integrity. The January 2016 pro...

    journal_title:Biochemia medica

    pub_type: 杂志文章,评审

    doi:10.11613/BM.2016.035

    authors: Krleža-Jerić K,Gabelica M,Banzi R,Martinić MK,Pulido B,Mahmić-Kaknjo M,Reveiz L,Šimić J,Utrobičić A,Hrgović I

    更新日期:2016-10-15 00:00:00

  • Sigma metrics in laboratory medicine revisited: We are on the right road with the wrong map.

    abstract::Reliable procedures are needed to quantify the performance of instruments and methods in order to increase the quality in clinical laboratories. The Sigma metrics serves that purpose, and in the present study, the current methods for the calculation of the Sigma metrics are critically evaluated. Although the conventio...

    journal_title:Biochemia medica

    pub_type: 杂志文章,评审

    doi:10.11613/BM.2018.020503

    authors: Oosterhuis WP,Coskun A

    更新日期:2018-06-15 00:00:00

  • Detection of acute kidney injury in premature asphyxiated neonates by serum neutrophil gelatinase-associated lipocalin (sNGAL)--sensitivity and specificity of a potential new biomarker.

    abstract:INTRODUCTION:Acute kidney injury (AKI) is common in neonatal intensive care units (NICU). In recent years, every effort is made for early detection of AKI. Our hypothesis was that serum neutrophil gelatinase-associated lipocalin (sNGAL) may be a reliable screening test for early diagnosis of AKI in premature neonates a...

    journal_title:Biochemia medica

    pub_type: 临床试验,杂志文章

    doi:10.11613/BM.2015.046

    authors: Pejović B,Erić-Marinković J,Pejović M,Kotur-Stevuljević J,Peco-Antić A

    更新日期:2015-10-15 00:00:00

  • Topiramate induced metabolic acidosis and kidney stones - a case study.

    abstract:INTRODUCTION:The aim of this study is to present a case of 44 years old woman with topiramate induced metabolic acidosis and kidney stones. MATERIALS AND METHODS:The laboratory features of topiramate caused renal tubular acidosis in blood and urine during topiramate treatment, with correction of metabolic acidosis by ...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2017.042

    authors: Salek T,Andel I,Kurfurstova I

    更新日期:2017-06-15 00:00:00

  • The diagnostic accuracy of clinical and laboratory parameters in the diagnosis of acute appendicitis in the adult emergency department population - a case control pilot study.

    abstract:Introduction:The evaluation of patients with suspected appendicitis strives to identify all patients with presenting symptoms while minimizing negative appendectomy rate. The aim of the study was to identify the optimal combination of clinical and laboratory parameters that should facilitate the emergency department su...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2018.030712

    authors: Soldo I,Radisic Biljak V,Bakula B,Bakula M,Simundic AM

    更新日期:2018-10-15 00:00:00

  • Significance of LDL and HDL subclasses characterization in the assessment of risk for colorectal cancer development.

    abstract:Introduction:Dyslipidaemia contributes to the occurrence of colorectal cancer (CRC). We hypothesized that qualitative changes of lipoproteins are associated with the risk for CRC development. This study analyses low-density lipoprotein (LDL) and high-density lipoprotein (HDL) diameters, as well as distribution of LDL a...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2018.030713

    authors: Stevanovic M,Vekic J,Bogavac-Stanojevic N,Janac J,Stjepanovic Z,Zeljkovic D,Trifunovic B,Spasojevic-Kalimanovska V,Zeljkovic A

    更新日期:2018-10-15 00:00:00

  • Effectiveness of citrate buffer-fluoride mixture in Terumo tubes as an inhibitor of in vitro glycolysis.

    abstract:INTRODUCTION:Glycolysis affects glucose determination in vitro. The placement of sample tubes in ice-water slurry with plasma separation within 30 minutes is recommended, or alternatively the use of a glycolysis inhibitor. The aim of our two-steps study was to evaluate which Terumo tube is best for glucose determinatio...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2016.006

    authors: Bonetti G,Carta M,Montagnana M,Lo Cascio C,Bonfigli AR,Mosca A,Testa R,Italian joint SIBioC-SIPMeL Study Group on Diabetes Mellitus.

    更新日期:2016-01-01 00:00:00

  • Using clinical guidelines to assess the potential value of laboratory medicine in clinical decision-making.

    abstract:Introduction:It is often quoted that 70% of clinical decisions are based on laboratory results, but the evidence to substantiate this claim is lacking. Since clinical guidelines aim to document best-practice decision making for specific disease conditions, inclusion of any laboratory test means that the best available ...

    journal_title:Biochemia medica

    pub_type: 杂志文章

    doi:10.11613/BM.2021.010703

    authors: Hicks AJ,Carwardine ZL,Hallworth MJ,Kilpatrick ES

    更新日期:2021-02-15 00:00:00