当前位置： SCI文献检索 > Biochemia Medica期刊下所有文献 > Classical pathway activity C3c, C4 and C1-inhibitor protein reference intervals determination in EDTA plasma.

Classical pathway activity C3c, C4 and C1-inhibitor protein reference intervals determination in EDTA plasma.

Abstract：

Introduction:Reference intervals (RIs) for complement assays in EDTA plasma samples have not previously been published. The objectives of the present study were to validate and/or determine RIs for classical pathway (CP50) activity and C3c, C4 and C1 inhibitor protein (C1INH) assays and to assess the need for age-specific RIs in EDTA plasma. Materials and methods:We retrospectively evaluated a cohort of 387 patients attending our university hospital and known to be free of complement-modifying diseases. The need for age partitioning was assessed and RIs were calculated according to the CLSI protocol. Results:No need for age partitioning was evidenced for CP50 activity, C3c and C4 concentrations and RIs (90% CI) were calculated from the pooled data: 35.4 (33.1-37.2) to 76.3 (73.7-83.6) U/mL for CP50 activity, 0.80 (0.75-0.87) to 1.64 (1.59-1.72) g/L for C3c, and 0.12 (0.10-0.14) to 0.38 (0.36-0.40) g/L for C4. Our results highlight a positive association between age and C1INH concentrations. We derived 3 age partitions (6 months to 30 years, 30-50 and > 50 years) and the related RIs: 0.20 (0.18-0.21) to 0.38 (0.36-0.40) g/L, 0.22 (0.20-0.24) to 0.39 (0.36-0.41) g/L and 0.25 (0.22-0.27) to 0.41 (0.40-0.43) g/L, respectively). Conclusions:The newly determined RIs for CP50 activity were higher than those provided by the manufacturer for EDTA plasma samples, whereas those for C3c and C4 RIs were similar to the values provided for serum samples. The C1INH concentration and activity were found to be associated with age and age-specific RIs are mandatory for this analyte.

journal_name

Biochem Med (Zagreb)

journal_title

Biochemia medica

authors

Lopez B,Bertier N,Ledoult E,Joudinaud R,Maanaoui M,Majerus V,Moitrot E,Deleplancque AS,Rogeau S,Launay D,Lefèvre G,Labalette M,Dubucquoi S

doi

10.11613/BM.2019.030707

subject

Has Abstract

pub_date

2019-10-15 00:00:00

pages

030707

issue

3

eissn

1330-0962

issn

1846-7482

pii

bm-29-3-030707

journal_volume

29

pub_type

杂志文章

相关文献

Biochemia Medica文献大全
  • Redefinition of gestational diabetes mellitus: implications for laboratory practice in Croatia.

    abstract：:An increasing prevalence of gestational diabetes has become a very challenging task in prenatal care worldwide. International Association of Diabetes and Pregnancy Study Groups (IADPSG) has recently issued recommendations on the diagnosis and classification of hyperglycaemia in pregnancy. These recommendations, the fi...

    journal_title：Biochemia medica

    pub_type： 社论

    doi：10.11613/bm.2013.002

    authors： Lovrencić MV,Honović L,Kralik S,Matica J,Prasek M,Pape-Medvidović E,Ivanisević M,Delmis J

    更新日期：2013-01-01 00:00:00

  • Storage stability of commonly used haematological parameters at 33 °C: Electronic supplementary material available online for this article.

    abstract：Introduction:This study aimed to investigate the analytical bias in haematological parameters induced by storage at 33 ºC. Materials and methods:Blood from the diversion pouch of 20 blood donors were collected in K 2 EDTA vials and stored at 33 ºC. Readings from each vial ...

    journal_title：Biochemia medica

    pub_type： 杂志文章

    doi：10.11613/BM.2018.020901

    authors： Jain A,Jain S,Singh N,Aswal P,Pal S,Meinia SK,Chowdhury N

    更新日期：2018-06-15 00:00:00

  • A case of severe pseudohyperkalaemia due to muscle contraction.

    abstract：Introduction:Severe hyperkalaemia is a serious medical condition requiring immediate medical attention. Before medical treatment is started, pseudohyperkalaemia has to be ruled out. Case description:A 10-month old infant presented to the emergency department with fever and coughing since 1 week. Routine venous blood t...

    journal_title：Biochemia medica

    pub_type：

    doi：10.11613/BM.2020.021004

    authors： Van Elslande J,Dominicus T,Toelen J,Frans G,Vermeersch P

    更新日期：2020-06-15 00:00:00

  • Detection of acute kidney injury in premature asphyxiated neonates by serum neutrophil gelatinase-associated lipocalin (sNGAL)--sensitivity and specificity of a potential new biomarker.

    abstract：INTRODUCTION:Acute kidney injury (AKI) is common in neonatal intensive care units (NICU). In recent years, every effort is made for early detection of AKI. Our hypothesis was that serum neutrophil gelatinase-associated lipocalin (sNGAL) may be a reliable screening test for early diagnosis of AKI in premature neonates a...

    journal_title：Biochemia medica

    pub_type： 临床试验,杂志文章

    doi：10.11613/BM.2015.046

    authors： Pejović B,Erić-Marinković J,Pejović M,Kotur-Stevuljević J,Peco-Antić A

    更新日期：2015-10-15 00:00:00

  • Economic evaluation of different screening alternatives for patients with clinically suspected acute deep vein thrombosis.

    abstract：INTRODUCTION:We examined the cost-effectiveness of the three different D-dimer measurements in the screening of DVT in models with and without calculation of pre-test probability (PTP) score. Moreover, we calculated the minimal cost in DVT detection. MATERIAL AND METHODS:In the group of 192 patients with clinically su...

    journal_title：Biochemia medica

    pub_type： 杂志文章

    doi：10.11613/bm.2013.012

    authors： Bogavac-Stanojević N,Dopsaj V,Jelić-Ivanović Z,Lakić D,Vasić D,Petrova G

    更新日期：2013-01-01 00:00:00

  • Effectiveness of citrate buffer-fluoride mixture in Terumo tubes as an inhibitor of in vitro glycolysis.

    abstract：INTRODUCTION:Glycolysis affects glucose determination in vitro. The placement of sample tubes in ice-water slurry with plasma separation within 30 minutes is recommended, or alternatively the use of a glycolysis inhibitor. The aim of our two-steps study was to evaluate which Terumo tube is best for glucose determinatio...

    journal_title：Biochemia medica

    pub_type： 杂志文章

    doi：10.11613/BM.2016.006

    authors： Bonetti G,Carta M,Montagnana M,Lo Cascio C,Bonfigli AR,Mosca A,Testa R,Italian joint SIBioC-SIPMeL Study Group on Diabetes Mellitus.

    更新日期：2016-01-01 00:00:00

  • Urinary free cortisol assessment by liquid chromatography tandem mass spectrometry: a case study of ion suppression due to unacquainted administration of piperacillin.

    abstract：Introduction:Liquid chromatography coupled to atmospheric pressure ionization tandem mass spectrometry (LC-ESI-MS/MS) is currently considered the reference method for quantitative determination of urinary free cortisol (UFC). One of the major drawbacks of this measurement is a particular form of matrix effect, conventi...

    journal_title：Biochemia medica

    pub_type： 杂志文章,评审

    doi：10.11613/BM.2017.031001

    authors： Danese E,Salvagno GL,Guzzo A,Scurati S,Fava C,Lippi G

    更新日期：2017-10-15 00:00:00

  • Utility of routine laboratory preoperative tests based on previous results: Time to give up.

    abstract：INTRODUCTION:The usefulness and cost-effectiveness of routine laboratory preoperative tests (POTs) have been challenged recently. In fact, the American Society of Anesthesiologists (ASA) Task Force has stated that test results obtained from the medical record within 6 months of surgery generally are mostly acceptable. ...

    journal_title：Biochemia medica

    pub_type： 杂志文章

    doi：10.11613/BM.2017.030902

    authors： Rodríguez-Borja E,Corchon-Peyrallo A,Aguilar-Aguilar G,Carratala-Calvo A

    更新日期：2017-10-15 00:00:00

  • The likelihood ratio and its graphical representation.

    abstract：:Diagnostic tests are important clinical tools. Bayes' theorem and Bayesian approach are important methods for interpreting test results. The Bayesian factor, the so-called likelihood ratio, has not always been well-understood. In this article, we try to discuss the likelihood ratio and its value for a specific test re...

    journal_title：Biochemia medica

    pub_type： 杂志文章,评审

    doi：10.11613/BM.2019.020101

    authors： Habibzadeh F,Habibzadeh P

    更新日期：2019-06-15 00:00:00

  • Indications for laboratory tests in primary care: assessment of the most frequent indications and requests with blank clinical information.

    abstract：INTRODUCTION:The aim of this work is twofold. Firstly, to study the temporal evolution in the number of laboratory requests from primary care without clinical indication, and to analyse the number of such requests before and after the implementation of an automated requesting procedure. Secondly, to investigate what ar...

    journal_title：Biochemia medica

    pub_type： 杂志文章

    doi：10.11613/BM.2016.045

    authors： Salinas M,López-Garrigós M,Flores E,Leiva-Salinas M,Esteban P,Ahumada M,Leiva-Salinas C

    更新日期：2016-10-15 00:00:00

  • Topiramate induced metabolic acidosis and kidney stones - a case study.

    abstract：INTRODUCTION:The aim of this study is to present a case of 44 years old woman with topiramate induced metabolic acidosis and kidney stones. MATERIALS AND METHODS:The laboratory features of topiramate caused renal tubular acidosis in blood and urine during topiramate treatment, with correction of metabolic acidosis by ...

    journal_title：Biochemia medica

    pub_type： 杂志文章

    doi：10.11613/BM.2017.042

    authors： Salek T,Andel I,Kurfurstova I

    更新日期：2017-06-15 00:00:00

  • Evaluating analytical quality in clinical biochemistry laboratory using Six Sigma.

    abstract：Introduction:In recent years, Six Sigma metrics has became the hotspot in all trades and professions, which contributes a general procedure to explain the performance on sigma scale. Nowadays, many large companies, such as General Healthcare, Siemens, etc., have applied Six Sigma to clinical medicine and achieved satis...

    journal_title：Biochemia medica

    pub_type： 杂志文章

    doi：10.11613/BM.2018.020904

    authors： Mao X,Shao J,Zhang B,Wang Y

    更新日期：2018-06-15 00:00:00

  • Sigma metrics in laboratory medicine revisited: We are on the right road with the wrong map.

    abstract：:Reliable procedures are needed to quantify the performance of instruments and methods in order to increase the quality in clinical laboratories. The Sigma metrics serves that purpose, and in the present study, the current methods for the calculation of the Sigma metrics are critically evaluated. Although the conventio...

    journal_title：Biochemia medica

    pub_type： 杂志文章,评审

    doi：10.11613/BM.2018.020503

    authors： Oosterhuis WP,Coskun A

    更新日期：2018-06-15 00:00:00

  • Significance of LDL and HDL subclasses characterization in the assessment of risk for colorectal cancer development.

    abstract：Introduction:Dyslipidaemia contributes to the occurrence of colorectal cancer (CRC). We hypothesized that qualitative changes of lipoproteins are associated with the risk for CRC development. This study analyses low-density lipoprotein (LDL) and high-density lipoprotein (HDL) diameters, as well as distribution of LDL a...

    journal_title：Biochemia medica

    pub_type： 杂志文章

    doi：10.11613/BM.2018.030713

    authors： Stevanovic M,Vekic J,Bogavac-Stanojevic N,Janac J,Stjepanovic Z,Zeljkovic D,Trifunovic B,Spasojevic-Kalimanovska V,Zeljkovic A

    更新日期：2018-10-15 00:00:00

  • Reference intervals for six salivary cortisol measures based on the Croatian Late Adolescence Stress Study (CLASS).

    abstract：Introduction:The aim of this nested study is to provide the reference intervals for already published measurements of salivary cortisol from the Croatian Adolescence Stress Study (CLASS). Material and methods:A total of 969 individuals (372 males and 597 females) were included in the reference sample (age range: 18-21...

    journal_title：Biochemia medica

    pub_type： 杂志文章

    doi：10.11613/BM.2018.010902

    authors： Šupe-Domić D,Milas G,Stanišić L,Drmić Hofman I,Martinović Klarić I

    更新日期：2018-02-15 00:00:00

  • IMPACT Observatory: tracking the evolution of clinical trial data sharing and research integrity.

    abstract：INTRODUCTION:The opening of research data is emerging thanks to the increasing possibilities of digital technology. The opening of clinical trial (CT) data is a part of this process, expected to have positive scientific, ethical, health, and economic impacts thus contributing to research integrity. The January 2016 pro...

    journal_title：Biochemia medica

    pub_type： 杂志文章,评审

    doi：10.11613/BM.2016.035

    authors： Krleža-Jerić K,Gabelica M,Banzi R,Martinić MK,Pulido B,Mahmić-Kaknjo M,Reveiz L,Šimić J,Utrobičić A,Hrgović I

    更新日期：2016-10-15 00:00:00

  • External Quality Assessment in Croatia: problems, challenges, and specific circumstances.

    abstract：:In Croatian medical laboratories (ML), external quality assessment (EQA) has a long tradition of almost half of a century. At national level, EQA is provided by Croatian Centre for Quality Assessment in Laboratory Medicine (CROQALM) which is a part of Croatian Society of Medical Biochemistry and Laboratory Medicine.
T...

    journal_title：Biochemia medica

    pub_type： 杂志文章,评审

    doi：10.11613/BM.2017.011

    authors： Krleza JL,Celap I,Tanaskovic JV

    更新日期：2017-02-15 00:00:00

  • Clinical and diagnostic utility of saliva as a non-invasive diagnostic fluid: 
a systematic review.

    abstract：:This systematic review presents the latest trends in salivary research and its applications in health and disease. Among the large number of analytes present in saliva, many are affected by diverse physiological and pathological conditions. Further, the non-invasive, easy and cost-effective collection methods prompt a...

    journal_title：Biochemia medica

    pub_type： 杂志文章,评审

    doi：10.11613/BM.2015.018

    authors： Nunes LA,Mussavira S,Bindhu OS

    更新日期：2015-06-05 00:00:00

  • Additional technician tasks and turnaround time in the clinical Stat laboratory.

    abstract：INTRODUCTION:Many additional tasks in the Stat laboratory (SL) increase the workload. It is necessary to control them because they can affect the service provided by the laboratory. Our aim is to calculate these tasks, study their evolution over a 10 year period, and compare turnaround times (TAT) in summer period to t...

    journal_title：Biochemia medica

    pub_type： 杂志文章

    doi：10.11613/BM.2016.027

    authors： Salinas M,López-Garrigós M,Flores E,Leiva-Salinas M,Lillo R,Leiva-Salinas C

    更新日期：2016-01-01 00:00:00

  • Determining biological variation of serum parathyroid hormone in healthy adults.

    abstract：Introduction:Measurement of parathyroid hormone (PTH) is essential in the investigation and management of calcium metabolism disorders. To assess the significance of any assay result when clinical decision making biological variation (BV) of the measurand must be taken into consideration. The aim of the present study i...

    journal_title：Biochemia medica

    pub_type： 杂志文章

    doi：10.11613/BM.2019.030702

    authors： Ercan M,Akbulut ED,Avcı E,Yücel Ç,Oğuz EF,Turhan T,Serdar M

    更新日期：2019-10-15 00:00:00

  • Peer-review policy and guidelines for Biochemia Medica Journal.

    abstract：:Peer review is widely used system for evaluating manuscripts prior to publication. It has been and still is widely used tool for making justified and fair editorial decision. However, the evidence of its efficacy is limited and it has been criticized to be time-consuming, biased, inconsistent, conservative, and open t...

    journal_title：Biochemia medica

    pub_type： 杂志文章

    doi：10.11613/BM.2014.034

    authors： Smolčić VŠ,Simundić AM

    更新日期：2014-10-15 00:00:00

  • Test validation, method comparison and reference range for the measurement of β-hydroxybutyrate in peripheral blood samples.

    abstract：Introduction:The measurement of β-hydroxybutyrate (βOHB) concentrations is a corner stone of the diagnosis of diabetic ketoacidosis and other ketonic states. The aim of this study was to perform a validation of a peripheral blood βOHB assay (Randox) on a Roche cobas c502 analyser and to establish a βOHB reference range...

    journal_title：Biochemia medica

    pub_type： 杂志文章

    doi：10.11613/BM.2020.010707

    authors： Kraus FB,Kocijancic M,Kluttig A,Ludwig-Kraus B

    更新日期：2020-02-15 00:00:00

  • A review of urinary angiotensin converting enzyme 2 in diabetes and diabetic nephropathy.

    abstract：:Urinary angiotensin converting enzyme 2 (ACE2) is significantly increased in diabetes and diabetic nephropathy. While studies on its clinical significance are still underway, its urinary expression, association with metabolic and renal parameters has been in the recent past considerably studied. The recent studies hav...

    journal_title：Biochemia medica

    pub_type： 杂志文章,评审

    doi：10.11613/BM.2019.010501

    authors： Gilbert A,Liu J,Cheng G,An C,Deo K,Gorret AM,Qin X

    更新日期：2019-02-15 00:00:00

  • The most common nonconformities encountered during the assessments of medical laboratories in Hong Kong using ISO 15189 as accreditation criteria.

    abstract：INTRODUCTION:ISO 15189 was a new standard published in 2003 for accrediting medical laboratories. We believe that some requirements of the ISO 15189 standard are especially difficult to meet for majority of laboratories. The aim of this article was to present the frequency of nonconformities to requirements of the ISO ...

    journal_title：Biochemia medica

    pub_type： 杂志文章

    doi：10.11613/bm.2012.027

    authors： Ho B,Ho E

    更新日期：2012-01-01 00:00:00

  • Analytical robustness of nine common assays: frequency of outliers and extreme differences identified by a large number of duplicate measurements.

    abstract：INTRODUCTION:Duplicate measurements can be used to describe the performance and analytical robustness of assays and to identify outliers. We performed about 235,000 duplicate measurements of nine routinely measured quantities and evaluated the observed differences between the replicates to develop new markers for analy...

    journal_title：Biochemia medica

    pub_type： 杂志文章

    doi：10.11613/BM.2017.021

    authors： Neubig S,Grotevendt A,Kallner A,Nauck M,Petersmann A

    更新日期：2017-02-15 00:00:00

  • The chi-square test of independence.

    abstract：:The Chi-square statistic is a non-parametric (distribution free) tool designed to analyze group differences when the dependent variable is measured at a nominal level. Like all non-parametric statistics, the Chi-square is robust with respect to the distribution of the data. Specifically, it does not require equality o...

    journal_title：Biochemia medica

    pub_type： 杂志文章

    doi：10.11613/bm.2013.018

    authors： McHugh ML

    更新日期：2013-01-01 00:00:00

  • How to conduct External Quality Assessment Schemes for the pre-analytical phase?

    abstract：:In laboratory medicine, several studies have described the most frequent errors in the different phases of the total testing process, and a large proportion of these errors occur in the pre-analytical phase. Schemes for registration of errors and subsequent feedback to the participants have been conducted for decades ...

    journal_title：Biochemia medica

    pub_type： 杂志文章,评审

    doi：10.11613/BM.2014.013

    authors： Kristensen GB,Aakre KM,Kristoffersen AH,Sandberg S

    更新日期：2014-02-15 00:00:00

  • The diagnostic accuracy of clinical and laboratory parameters in the diagnosis of acute appendicitis in the adult emergency department population - a case control pilot study.

    abstract：Introduction:The evaluation of patients with suspected appendicitis strives to identify all patients with presenting symptoms while minimizing negative appendectomy rate. The aim of the study was to identify the optimal combination of clinical and laboratory parameters that should facilitate the emergency department su...

    journal_title：Biochemia medica

    pub_type： 杂志文章

    doi：10.11613/BM.2018.030712

    authors： Soldo I,Radisic Biljak V,Bakula B,Bakula M,Simundic AM

    更新日期：2018-10-15 00:00:00

  • Preanalytical phase--a continuous challenge for laboratory professionals.

    abstract：:Preanalytical phase is the most vulnerable part of the total testing process and is considered to be among the greatest challenges to the laboratory professionals. However, preanalytical activities, management of unsuitable specimens and reporting policies are not fully standardized, nor harmonized worldwide. Several ...

    journal_title：Biochemia medica

    pub_type： 社论

    doi：10.11613/bm.2012.017

    authors： Simundic AM,Lippi G

    更新日期：2012-01-01 00:00:00

  • The effective reduction of tourniquet application time after minor modification of the CLSI H03-A6 blood collection procedure.

    abstract：INTRODUCTION:The phlebotomists' procedures are a still source of laboratory variability. The aim of this study was to verify the efficacy of minor modification in procedure for collection of diagnostic blood specimens by venipuncture from CLSI H03-A6 document is able to reduce the tourniquet application time. MATERIAL...

    journal_title：Biochemia medica

    pub_type： 杂志文章

    doi：10.11613/bm.2013.037

    authors： Lima-Oliveira G,Lippi G,Salvagno GL,Montagnana M,Picheth G,Guidi GC

    更新日期：2013-01-01 00:00:00